Mutant's Insulin Protocol

Mutant's Insulin Protocol

Ok, so after talking to some professional and elite bodybuilders, I have learned quite a bit about what a well known professional trainer is having these bodybuilders to do to obtain the extreme amounts of weight they have been added to their bodies. It's simply taking their insulin pre-workout, combined with 3 "shakes". I looked at this Insulin protocol, and the ingredients in the shakes, and designed my own Insulin Protocol to better suit my goals and routine. I use better quality of ingredients in my shakes, and added my HGH pre-workout, and igf-1lr3 post workout as well.

Now, the theory behind this insulin protocol is, "Why break the body down, only to rebuild it? When you can simply keep adding onto the Body!"

So basically, by forcing the carbohydrates and Essential Amino Acids into your muscles while you train, the muscle tissue is not breaking down in the same manner that they normally would. It is actually being both protected and forced to grow at the same time. I have not done too much research behind the theory, but it sure sounded good to me, based on what I know about enhancing drugs and supplementation. I prefer trying things out myself, and going by results. Well, the results were spectacular.

Before I begin, I want to say that this typed out protocol is just a base. It is to give you a base to work from/with. Everybody is different. Some people will need more or less carbs and amino acids. This is based on the amount of insulin that they are using and how their bodies react. This is why I gave a range for the supplements and insulin doses. You will need to adjust it based on how you react. For the carbohydrates, always start high, and lower it accordingly, once you get the feel of it.

We start off by taking our HGH, and give it a few minutes to get circulating, before we add our insulin. The idea behind this, is to make sure that the HGH passes the liver while we have a substantial amount of insulin in the body. This is how we produce large IGF-1 spikes. After the workout, we go home and take our IGF-1LR3. We are taking this to increase our insulin sensitivity, and to help use up any of those receptors that we have not filled. I could go more into detail, but if you are using this protocol, you should already know all about the drugs, and should be able to put it together yourself.

- -30 min prior to workout: Take 10iu HGH subq

- -15 min prior to workout: Take 6-16iu Novalog subq

- -10 min prior to workout: Drink shake #1

- -After every working set: Sip on shake #2, and finish by end of workout

- -Go home

- -Take 100mcg of the IGF-1lr3 (for it's insulin sensitizing effects)

- -Take down shake #3

- -Done..now you are huge

Ok, now what is in the shakes...

Shake 1: 10-20g EAA's or PeptoPro, 40-60g Low DE Maltodextrin, 5g Micronized Creatine Monohydrate, 200mg Caffeine (or pre-workout powdered mix of choice in place of caffeine)

Shake 2: 10-20g EAA's or PeptoPro, 50-100g Dextrose, 5g Micronized Creatine Monohydrate

Shake 3: 2 cups pasteurized egg whites, 1 cup dry oats, 1 banana or 1 cup blueberries (I prefer them to be frozen), splenda or stevia

*There is no need for a supplemented post workout shake because your glycogen will not be depleted, and you will have been ingesting aminos the whole time too. So dense whole food calories with low fat content, are going to be the best option here. So we throw it in a blender and take it down.

Now, I would like to advise you cheap-skates, not to go out and buy the cheapest ingredients that you can find. Please pick quality supplements. It does and will make a difference. Spend the extra 2$ and buy some quality shit, or your results may be skewed. Thinks about it this way: Your body is a Lamborghini. Would you fill your tank with low grade octane from Costco? No, of course not, it would run like shit. So use quality supplements, not bulk junk crap, and your results will be that much better!

Supplement idea for those of you who need to be pointed in the right direction:

EAA's: Champion Nutrition makes a good EAA product that has creatine in it, and also one that has caffeine too. It's called Amino Shooter. There are 3 versions. None are a proprietary blend, and they are made with pharmacy grade aminos.

PeptoPro: This can be used in place of the EAA's. It is a high quality peptide/EAA product made from hydrolyzed casein. Different companies buy PeptoPro and flavor it. One brand I have tried that is flavored is MAP by Primordial Performance.

Low DE Maltodextrin: This means Low Dextrose Equivalency. The lower the equivalence, the more complex of a chain it is, and the slower it will break down into a sugar. A couple good ones are Carb Complex by Nutek, and Cytocarb 2 by Cytosport. If corn maltodextrins give you stomach problems, then other water soluble carbohydrates like Karbolyn can work. They just tend to be expensive, and do the same exact thing. Some people that have used this protocol with success, have actually used dextrose in place of the maltodextrin due to stomach problems.

Dextrose: Yes, you can find this anywhere, but I prefer AST's DGC because it also contains vitamins.

Micronized Creatine Monohydrate: Well, the name says it all. Any brand that uses Creapure as the source of their creatine monohydrate, should be just fine. I use Bioplex.

*Do not use cheap starch carbs, like waxy maize, in the shakes. The carbs need to be water soluble and easily digested. By keeping them soluble, they help pull the aminos in.

I decided to throw this protocol together after I had my leg surgery, in hopes of gaining some abnormal amounts of muscle back that I had lost. I can tell you that I did, and this protocol works better than any protocol I have ever used. I started off at 204 - 205lb, and ended up at 234 after 4-5 weeks! I was taking anabolics on the side, but I guarantee that amount of insane weight, that fast, was not from the long estered steroids I was taking. I literally filled out instantly. When I dropped the insulin, I only lost a few pounds of water, and retained most, if not all, of my strength. So the gains were very solid, and not just a bunch of glycogen storage.

I do not want to post this on the open forums because there are too many idiot kids out there that will attempt this protocol in hopes of becoming an instant monster (which wont happen for them), and they will mess it up somehow. Maybe by being stupid, maybe by cutting corners, maybe by using cheap ingredients. Who knows? I don't need people hurting themselves, or not having good results, and them coming back and complaining. Even though they were the ones cutting corners!

So, there it is boys. Some people are paying big money for this type of info. It's nothing special. It's just different, but it makes sense and it works.

*Added note: Since this protocol was designed and posted, a handful of advanced users have tried it as part of their bulking regime. They have also had great success. all you need to know insulin protocol

 

 discuss this further here

Good Luck and Stay safe MUTANT

More Peptide Info...

IGF-1 Long R3

R3(long) IGF-1

1: Type- IGF-1 Long R3 (Anything else is not as effective, and if the person providing it for you doesn't know anything about it, you are asking for trouble.)

2. Storage- the most popular (and most effective) way to store, transport, preserve IGF is by suspending it in sterile BA in a sterile vial.
This will keep your IGF 99% potent for many months at a time in just about ANY indoor storage, I.E.-closet, drawer, etc. (Take it from me, I stored mine because I wasn't ready to use it for about 6 months in my closet... I had fears about its potency, then I started my first week, and BAM I practically cleaned out the fridge.

3. Use- Usage should not exceed 4-5 weeks, and an OFF period should be about the same. Daily dosages work best (split up into 2 seems to make little difference in the Long R3 version) Most people see results at about 40mcg/day, some use as low as 30mcg/day, and some folks even use 80-100mcg. I SUGGEST to ALL first time users no matter what level, to start at about 40-50mcg/day.

4. Administration- I believe in IM injections over sub q, but either seems to be effective. I like IM better because IM using a slin pin is probably the least painful thing one could imagine, even at two times per day. Also, sub Q shots that contain BA, even diluted BA, can leave little nodules that you may not want to feel on your stomach.

5. Mixing- Most IGF comes suspended in BA. Hopefully it is @ 500mcg/ml or even 333mcg/ml (that would be at 2ml/mg and 3ml/mg respectively) Draw out your desired amount and back load a slin pin. Add enough Bacteriostatic Water to fill the U100 syringe completely.
Some inject immediately before training, while others choose to do 2 shots spread throughout the day... THEY BOTH WORK WELL. Try both; see which method makes your muscles pop out of your skin.

6. Add plenty of protein, and don’t shy away from carbs immediately after training. I used up to 100g of carbs after training, and my body fat went down, all without cardio.

More Peptide Info...

A New Peptide Treatment For Healing Acne Scars

A New Peptide Treatment For Healing Acne Scars

Peptides have made their way to the forefront of skin care industry over the past few years, with a wide variety of treatments. Most popular for their removal of wrinkles, their use does not stop there. Peptides have been used to remove discoloration within the skin and even in the treatment of burn victims. Recently, the use of peptides has stepped out of anti aging and into an equally popular treatment, that of acne scar removal. Because peptides work on the cellular level of the skin, they are very good at growing new skin cell which heals wrinkles but it can also heal the damaged tissue common with acne scars.

The peptide Collaxyl is the peptide in question. Collaxyl is a poly peptide that penetrates deep into the skin and heals damaged, and even dead tissue. In a clinical study, Collaxyl was applied to a sample of dead skin and damaged tissue. After applying only one dose, and waiting a period of time of 72 hours Collaxyl proved to completely heal the damaged tissue sample. This is by far the most amazing results of tissue repair that scientists have ever seen, and as a result they turned this ingredient into treatment for acne scars.

Acne scars are far more common than you may imagine, and anyone who suffers from them will tell you, getting rid of them is far more difficult than it is to get them. And what is even more frustrating is that acne scarring is common because it is a side effect of your skin's natural defense against acne. Most of us know that acne is caused by bacteria growing in the skin along with excess dirt, oils and dead skin cells. Once the breakout begins, the skin naturally floods the area with white blood cells to nourish and treat the acne. While this heals the breakout themselves, it provides the skin with so much blood flow that the tissue remains inflamed and damaged for periods of time that can range between a few days and a few years, and in some extreme cases can remain permanently.

It is this condition of the skin, immediately following the acne breakout that can lead to acne scars. Making the mistake of letting this condition go untreated can result in severe acne scarring for many individuals. This is where the Collaxyl comes in handy. By using this ingredient on your skin you can protect against the potential for acne scars as well as eliminate the scars that already exist. Breaking down scar tissue and repairing inflamed or damaged tissue is what Collaxyl does. While the clinical tests described above were only one application over a 72 hour period of time, imagine the possibilities when applied twice daily.

If the past few years has taught us anything, it has taught us that the treatments of the skin will constantly be changing, evolving, hopefully for the better. This is the case with peptides over the past few years; making their way into the anti aging market and now have penetrated the acne scar removal industry. Collaxyl has proven up to the task, delivering acne scar removal qualities that are unseen by any other treatment of its kind. Scars are broken down and healed effectively, making acne scar fading creams with the ingredient Collaxyl the best that money can buy.

By Mark A Robbins

More Peptide Info...

all about Igf-1

all about Igf-1

IGF stands for insulin-like growth factor. It is a natural substance that is produced in the human body and is at its highest natural levels during puberty. During puberty IGF is the most responsible for the natural muscle growth that occurs during these few years. There are many different things that IGF does in the human body; I will only mention the points that would be important for physical enhancement. Among the effects the most positive are increased amino acid transport to cells, increased glucose transport, increased protein synthesis, decreased protein degradation, and increased RNA synthesis.

When IGF is active it behaves differently in different types of tissues. In muscle cells proteins and associated cell components are stimulated. Protein synthesis is increased along with amino acid absorption. As a source of energy, IGF mobilizes fat for use as energy in adipose tissue. In lean tissue,

IGF prevents insulin from transporting glucose across cell membranes. As a result the cells have to switch to burning off fat as a source of energy.

IGF also mimic’s insulin in the human body. It makes muscles more sensitive to insulin’s effects, so if you are a person that currently uses insulin you can lower your dosage by a decent margin to achieve the same effects, and as mentioned IGF will keep the insulin from making you fat.

Perhaps the most interesting and potent effect IGF has on the human body is its ability to cause hyperplasia, which is an actual splitting of cells. Hypertrophy is what occurs during weight training and steroid use, it is simply an increase in the size of muscle cells. See, after puberty you have a set number of muscle cells, and all you are able to do is increase the size of these muscle cells, you don’t actually gain more. But, with IGF use you are able to cause this hyperplasia which actually increases the number of muscle cells present in the tissue, and through weight training and steroid usage you are able to mature these new cells, in other words make them grow and become stronger. So in a way IGF can actually change your genetic capabilities in terms of muscle tissue and cell count. IGF proliferates and differentiates the number of types of cells present. At a genetic level it has the potential to alter an individuals capacity to build superior muscle density and size.

There is a lot of talk about the similarity between IGF and growth hormone. The most often asked question is simply which is more effective. GH doesn’t directly cause your muscles to grow, it works very indirectly by increasing protein synthesis capabilities, increasing the amount of insulin a person can use effectively, and increasing the amount of anabolic steroids a person can use effectively. GH also indirectly causes muscle growth by stimulating the release of IGF when it (the GH) is destroyed in the human body. So one way you could look at it as GH being a precursor to IGF. So to put it simple IGF is more effective at directly causing muscle growth and density increases. IGF is also much more cost effective.

IGF can also be effectively used by itself and gains will still be easily noticeable. With growth hormone you need to use high amounts of anabolics and often insulin to see any gains at all, this is not the case with IGF. IGF can be used by itself and is often used by bodybuilders who bridge between cycles, during this bridge is a good time to use IGF since it has no effect on natural testosterone production so it will therefore allow you to return to normal in terms of hormone levels. A stack of IGF, PGF2a, HCG, and clomid would be a good bridge stack and would allow your body to return to normal and still allow you to retain and make new gains.

IGF is a research drug, it hasn’t been approved by the FDA for use as a pharmaceutical and it is currently being researched for nerve tissue repair, possible burn victims, and also as a possible aid in muscle wasting for AIDS patients. There are many different analogs of IGF available, instead of mentioning them all, I will simply mention the two most common and the most effective. Regular recombinant IGF is one of the two, it is also the more expensive and the least effective. Regular IGF only has a half-life of about 10-20 minutes in the human body and is quickly destroyed, it can be combined with certain binding proteins to extend the half-life, but it is not a very simple procedure and there is a more effective and less expensive version available. The most effective form of IGF is Long R3 IGF-1, it has been chemically altered and has had amino acid changes which cause it to avoid binding to proteins in the human body and allow it to have a much longer half life, around 20-30 hours. “Long R3 IGF-1 is an 83 amino acid analog of IGF-1 comprising the complete human IGF-1 sequence with the substition of an Arg(R) for the Glu(E) at position three, hence R3, and a 13 amino acid extension peptide at the N terminus. This analog of IGF-1 has been produced with the purpose of increasing the biological activity of the IGF peptide.”

“Long R3 IGF-1 is signifacantly more potent than IGF-1. The enhanced potency is due to the decreased binding of Long R3 IGF-1 to all known IGF binding proteins. These binding proteins normally inhibit the biological actions of IGF’s.”

It is also not as expensive since a media grade version is available which is sufficient for bodybuilding use. There is also a receptor grade available but it is VERY expensive and the only noticeable difference between the two would only be able to be noticed in a laboratory setting. The price on the black market for Long R3 IGF-1 can be seen anywhere from $300-$500 per milligram depending on the source, be wary of black market dealers of any IGF since it is a VERY difficult item to obtain. As mentioned IGF is a research product and is only available from a few laboratories in the world and is only available to research companies and biotechnology institutions. For the rest of this article when I say IGF I am now referring to Long R3 IGF-1 for simplicity sake.

Any form of IGF is ONLY supplied in a lyphosized form, which means a dry powder state. NEVER PUCHASE PRE-DILUTED LIQUID IGF!!!! There is no such product made anywhere in the world and even if there were real IGF ever present in the vial it would all be dead by the time you receive it. IGF is a very delicate peptide and must be diluted by yourself, where you have access to a refrigerator and freezer. There has also been a lot of talk by certain sources claiming to have IGF made by the Eli Lilly company, to clear things up Lilly is a pharmaceutical company and as stated IGF is a research drug and has not yet been approved, Lilly does not and never has manufactured research drugs for retail sale.

The dilutents you will need for the IGF are a weak concentration of hydrochloric acid and a sterile buffer(sterile water or bacteriostatic water) the procedure for diluting the IGF is not very difficult, the dilutents can be obtained from most local chemical suppliers and a good source of IGF would also be able to supply the necessary dilutents.

The most effective length for a cycle of IGF is 50 days on and 20-40 days off. The most controversy surrounding Long R3 IGF-1 is the effective dosage. The most used dosages range between 20mcg/day to 120+mcg/day. IGF is only available by the milligram, one mg will give you a 50 day cycle at 20mcg/day, 2mg will give you a 50 day cycle at 40mcg/day, 3mg will give you a 50 day cycle at 60mcg/day, 4mg will give you a 50 day cycle at 80mcg/day and so on. The dosage issue mainly revolves around how much money you have to spend, plenty of people use the minimum dosage of 20mcg/day and are happy with the results, and in fact several top bodybuilders use the 20mcg/day dosage and are pleased with the results. IGF is most effective when administered subcutaneously and injected once or twice daily at your current dosage. The best time for injections is either in the morning and/or immediately after weight training.

Another frequently asked question of IGF refers to the real world results, in terms of pure weight gain don’t expect to gain 5 lbs. a week like you may off of anadrol or a similar steroid. The only weight you will gain from IGF use is pure lean muscle tissue, with steroids most of the weight gained is water weight. With an effective dosage you can expect to gain 1-2 lbs of new lean muscle tissue every 2-3 weeks and these effects can be increased with the use of testosterone, anabolic steroids, and insulin use. Increased vascularity is also very common, people report seeing veins appear where they never have before. And yet another effect reported is the ability to stay lean while bulking with heavy dosages of steroids and TONS of food while on an IGF cycle, this is perhaps the most pleasing effect. Increased pumps are also noticeable almost immediately, the pumps can almost become painful, pumps are even noticeable when doing cardio.

Overall, IGF is a very exciting drug due to its ability to alter ones genetic capabilities. If you can find a trustworthy source and you use it correctly it can be a VERY useful tool in your bodybuilding drug arsenal

IGF1, also known as somatomedin C, is polypeptide hormone about the same size as insulin. It is produced predominantly in the liver in response to growth hormone (GH) release from the pituitary gland. Many of the growth promoting effects of GH are due to its ability to release IGF1 from the liver. The conversion ratio of GH to IGF1 varies greatly in different individuals but most external sources of GH convert around 4-6mcg of IGF per one I.U. of GH. IGF-1 acts on several different tissues to enhance growth. IGF1 belongs in the ’superfamily’ of substances known as ‘growth factors,’ along with epidermal (skin), transforming; platelet derived fibroblast, nerve, and ciliary neurotrophic growth factors. None of the other factors have any bearing on exoskeletal tissue incidentally however These agents all have in common the ability to stimulate cell division, known as mitogenesis, and cell differentiation. Meaning That In the case of IGF1 which does act on muscle tissue it will initiate the growth of new muscle fibers, and subsequently new receptors for testosterone. Users have unanimously concluded that it enhances cycles of steroids significantly. They also seem to be adamant about its ability to reduce fat and improve vascularity a great deal.

The IGF1 Hype
There is a considerable amount of hype surrounding IGF1. Every one is blaming the distended bellies of modern Bodybuilders on it. Also the freaky proportions that old bodybuilders that have been around for years are starting to attain. Anti-aging proponents are touting it as the miracle cure for every thing from Parkinson’s disease to Alzheimer’s. And the medical community has published numerous articles on it for its ability to cause cancer, diabetes and gigantism. While at the same time performing documented experiments on thousands of patients of muscle wasting diseases. And reporting significant turnabouts in there conditions. So what is a guy to think about IGF1 as far as athletic enhancement is concerned? Well first of all you need to know that most experiments conducted with IGF1 do not list the type of IGF used. I have written Dr. Robert Saline of the Swedish rejuvenation institute on several occasions and we have had in-depth discussions on the subject of IGF1 for physical appearance enhancement. He feels it would be unethical to prescribe IGF1 to a bodybuilder to increase muscle mass simply due to the fact that IGF1 has valid applications in the medical community, (Like I could give a rats ass about “ethical”). He can not argue that it is extremely effective as a promoter of muscle growth far beyond what androgens (steroids) alone can offer. Well fortunately in America IGF1 is not a drug (yet) and the FDA has no control over it as of now. This will change in the very near future however, Im absolutely sure of it.

How to use IGF1
Assuming that you have acquired legitimate IGF1 (R3) long chain, That’s IGF1 with the binding protein added. You should take dosages ranging from 60mcg up to 120mcg per day in divided doses. One injection in the morning and again at bed time. Never exceed 120mcg in one day. IGF1 can cause serious gastrointestinal problems such as tumors intestinal swelling diarrhea and vomiting. Most IGF1 comes in a concentration of 1000mcg per ML or CC so it makes it easy to measure in an insulin syringe. 10 IU on the syringe is 100mcg. Do the math.

IGF + Insulin
If you plan on doing IGF1 with Insulin, listen closely IGF1 is not that expensive, sure you can get away with using less by including insulin in the stack, but IGF1 and Insulin together have a pro-insulin effect on your blood sugar balance. It can enhance the chances of a hypoglycemic episode ten fold. I would recommend against it for any one not ABSOLUTLY comfortable with insulin or IGF1.

Here is how insulin and IGF1 work together. Igfbp3 is the binding protein, which allows IGF1 to remain active in the system for a long enough period of time to really work its magic. IGF1 by nature has a half-life of less than 10 minutes by its self. The molecule was so small it would escape the blood stream very rapidly. This was the reason IGF1 was so “underground”. It took very frequent injections at high dosages to achieve even minimal results. Aside from this reconstituting the compound required a degree in biochemistry. This short acting version was the only IGF1 known until recently IGF1 would have been administered in 100 mcg dosages 4-6 times a day. That is a hell of a lot of IGF1. That explains a lot of the distended bellies. Now with R3 long chain IGF1 and the Binding protein IGFBP3 IGF1 will last up to 6 hours in the system. By binding IGF to the IGFBP3 you make the molecule larger and it gets trapped in the blood stream until the protein is broken down and the IGF molecule escapes. You can further its life by combining Insulin with it, although I here its very risky. Insulin prevents the breakdown of IGFBP3 and leaves the IGF1 molecule roaming free in the blood stream for longer periods of time up to 12 hours as insulin levels return to normal IGFBP3 will begin to break down and the IGF1 will escape from its bound protein IGFBP3 again having a half life of less than 10 minutes.

Insulin should be taken at the normal dosage it is usually administered at minus 10% about 45 minutes prior to the IGF1 infusion. Again let me remind you this can be deadly if you don’t know what you are doing. And of course do not use Insulin for the nighttime injection of IGF1 by taking it in the morning you prolong the IGF1’s half life to 12 hours and then take a 6 hour injection, you should be fine. Hell if you want to eat a big bowl of rice and drink another 100g of simple carbs 45 minutes before the bed time IGF1 infusion you could spike insulin for at least a few hours of extended IGF1 activity. If your not going to be using insulin in the stack then go ahead and do the same in the morning.

What users report
Users of IGF1 have reported various results but all along the same lines, It does not appear to be dramatically less effective in any one individual (at least not to the best of my knowledge). I have a good friend who had to stop taking IGF1 due to stomach illness that was completely unrelated But he to experienced good gains from it for the 2 weeks he was on it, his dosage was 120mcg per day. One hour after the first injection he went to the gym and immediately told me about the uncontrollable pump he got from just one set.

That would indicate to me that he was experiencing some form of cell volumization. The general consensus on IGF1 seems to be that its benefits are as fallow:

Increased Pump Pumps are reported to be so severe that workouts are often cut short due to lack of ability to the muscle through the full range of motion…ouch

Gains retention is increased if IGF is used in a cycle I am not sure why, but IGF1 seems to make gains on a cycle stick with virtually no post cycle loss. Every bodybuilder I’ve spoken with seems to think this for some reason. Most of them use drugs like Anadrol or Dianabol with it because of the amount of size attained with these drugs. The usual draw back to these drugs is that in most users there is a post cycle “crash” that occurs, so the reasoning is to toss IGF1 into the stack and grow larger faster with out the post cycle crash blues.

Reverses testicular atrophy
Testicles if shrunken will return to “full swing” so to speak even in the middle of a cycle. If not shrunken they will not shrink during the cycle. This may explain partially why gains are kept after the cycle.

Fatigue
Users report feeling drained and tired all day. This seems to be one of the negative side effects to IGF1, it will make you sleep longer and you will require more sleep at night to feel rested for the morning. This is common with high doses of HGH and exhibited in children, whose IGF1 levels are extraordinarily high. A child needs 4 hours more sleep than an adult on average does. This may be directly or indirectly related to IGF1 levels.

Stiffness
An almost arthritic feeling is commonly associated with high levels of HGH, well IGF1 has the exact same property. IGF1 will cause your hands, fingers and knuckles to ache this is one way you can be sure you got real IGF1.

IGF-1’s Side effects
Every thing has a down side. To bake a cake ya gotta brake an egg. IGF1 is no exception. The drug used in larger quantity around the 100mcg+ range will cause headaches, occasional nausea and can contribute to low blood sugar or hypoglycemia in some users. Although I have never heard of this first hand I’m sure its true.

IGF1 will attach its self to the lining of the intestine and cause atrophy of the gut. Every thing IGF1 touches will grow and you have a lot of receptors on the lining of the large intestine and inner wall of the abdominal well. This is what causes the GH gut look. You can easily avoid this by limiting your dosages and cycle lengths. IGF1 cycles should be kept to 4-6 weeks with 4-6 weeks off in-between. IGF-1 is considerably more powerful than HGH and you need to think of it along those lines as far as dosing goes. We all know what to much HGH can do over prolonged periods of usage. The Neanderthal look is definitely not going to win any shows this year. I would recommend 80 mcg a day for 4 weeks at a time you should get good results from that for a while. I don’t know if you will need to up the dosage at any point, but I would think in the case of IGF1 it wouldn’t matter. If 80mcg doesn’t do it for ya, then bump it up to 100 You should definitely feel it at this point If not suspect the IGF1 as being fake. Beyond 120 mcg per day your asking for trouble, This compound demands as much respect as its sister amino Insulin.

Clinical Facts about IGF-1
IGF-1 is a polypeptide of 70 amino acids (7650 daltons), and is one of a number of related insulin-like growth factors present in the circulation. The molecule shows approximately 50% sequence homology with proinsulin and has a number of biological activities similar to insulin. IGF-1 is a mediator of longitudinal growth in humans or how tall you are capable of becoming. Serum IGF-1 concentrations are altered by age, nutritional status, body composition, and growth hormone secretion. A single basal IGF-1 level is useful in the assessment of short stature in children and in nutritional support studies of acutely ill patients. For the diagnosis of acromegaly, a single IGF-1 concentration is more reliable than a random hGH measurement (Oppizi, et al., 1986). IGF-1 can be used for the assessment of disease activity in acromegaly (Barkan, et al., 198.

Almost all (>95%) of serum IGF-1 circulates bound to specific IGF binding proteins (IGFBPs), of which six classes (IGFBPs 1-6) have been identified (Rudd, 1991). BP3 is thought to be the major binding protein.

More Peptide Info...

HGH fragment 176-191

HGH fragment 176-191

* Reduces the most stubborn abdominal fat.
* Increases muscle mass.
* Increases IGF-1 levels, in an effective manner, thus making this a peptide that burns fat and exhibits anabolic function.
* Increases energy expenditure.
* Improves lipid profiles and lipolytic activity.
* Does not negatively impact blood glucose level, nor does cell proliferation occur, like Human Growth Hormone.
* Extremely potent and effective fat burner.




The (HGH fragment 176-191) is a stabilized analogue of the growth hormone-releasing factor (GRF) that induces growth hormone (GH) in a specific and physiological manner. To date studies suggest that (HGH fragment 176-191) has several beneficial features: it reduces abdominal fat (in particular visceral fat), without compromising glycemic control (blood glucose), it increases muscle mass and improves the lipid profile. These characteristics make it an ideal candidate for the treatment of excess abdominal fat, an important aspect of HIV-associated lipodystrophy.
At a dosage of 500mcg the (HGH fragment 176-191) was shown to increase lipolytic activity in adipose tissue. In other words this fragment potently burns body fat, especially stubborn adipose body fat, and it does so potently! Of significance, is that the fragment has no negative impact on insulin sensitivity, a stark contrast from its Human Growth Hormone counterpart.(Ng FM, Sun J,Sharma L, Libinaka R, Jiang WJ, and Gianello R 2000).
Not only does the (HGH fragment 176-191) not interfere with the body~~~8217;s natural insulin regulation as Human Growth Hormone can, the (HGH fragment 176-191) does not result in cellular proliferation as Human Growth Hormone does. The fragment is similar to Human Growth Hormone, hence the shared amino acid sequence, however, the (HGH fragment 176-191) does not induce hyperglycaemia or reduce insulin secretion. The (HGH fragment 176-191) does not compete for the hGH receptor and nor does it induce cell proliferation, unlike Human Growth Hormone. (Wu Z, Ng FM. 1993). Thusly, this is a very beneficial peptide in terms of burning fat, without unwanted and undesirable side effects. Of particular note is the fragments ability to increase IGF-1 levels which translate into the fragments ability to give collateral anti-aging and anabolic effects along with its ability to induce lipplytic (fat burning) activity.
In yet another study, the (HGH fragment 176-191) exhibits the ability to burn through adipose tissue by increasing lipolytic activity (the breakdown of fat) , in the most stubborn body fat (adipose tissue) while increasing energy expenditure and glucose and fat oxidation in ob/ob mice treated with (HGH fragment 176-191). In addition, (HGH fragment 176-191) increased in vitro lipolytic activity and decreased lipogenic activity in isolated adipose tissue from obese rodents and humans.(Heffernan MA, Jiang WJ, Thorburn AW, Ng FM. 2000).
Thusly, the (HGH fragment 176-191) exhibits the ability to burn through stubborn adipose tissue, while increasing energy expenditure, muscle mass, and fat oxidation. All studies have pointed to the fact that the fragment is an effective treatment for obesity and fat loss, and much safer than its Human Growth Hormone counterpart.

Includes Sodium Chloride for Dilution, all vials are dosed at 2mg (2000mcg).



-The mean Relative Insulin Resistance (RIR) increased in all groups with no statistically significant differences among groups (Figure 2).
-There were no statistically significant treatment differences in the changes from the baseline in fasting insulin levels and OGTT insulin (data not shown).


-At week 12, a statistically significant treatment difference (p=0.04, ANOVA) in mean total cholesterol was observed.
-Values increased by 5% and 3% in the placebo and 1 mg groups, respectively and decreased by 6% in the 2mg group (Figure 5).
-Changes were significantly different in the 2mg group when compared to the placebo and 1mg groups (p<0.05), and were mainly explained by comparable changes in the mean non-HDL cholesterol values (Figure 5.).
-HDL cholesterol and triglycerides levels remained unchanged (data not shown).

-Mean IGF-1 levels increased in a dose dependant manner over the study period (Figure 6).
-IGF-1 increases were associated with no clear dose-related pattern of adverse events suspected to be related to the study drug.
.

RESEARCH DOSAGE: frag 176-191

500mcg-2mg every day
STORAGE:
REFRGIRATE UPON RECEIPT.
KEEP REFRIGERATED AFTER RECONSTITUTION ALLOW 24 HOURS FOR THE PEPTIDE TO SETTLE BEFORE BEGINNING YOUR RESEARCH.
NCLUDES SODIUM CHLORIDE FOR DILUTION Academic References & Further Information
Heffernan MA, Jiang WJ, Thorburn AW, Ng FM. (2000). Effects of oral administration of a synthetic fragment of human growth hormone on lipid metabolism. Am J Physiol Endocrinol Metab. 2000 Sep;279(3):E501-7.
Ng FM, Sun J,Sharma L, Libinaka R, Jiang WJ, and Gianello R (2000). Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone. Horm Res. 2000;53(6):274-8.
Wu Z, Ng FM (1993). Antilipogenic action of synthetic C-terminal sequence 177-191 of human growth hormone. Biochem Mol Biol Int. 1993 May;30(1):187-96.

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Blast Protocol: HGH IGF Insulin

Blast Protocol: HGH IGF Insulin

I highly recommend using a minimal schedule for all short chain sequence peptides, which include igf, insulin and even gh. I recommend using no more than 3 days per week, 2 days is fine, but no more than 3. The reason for this is that we are trying to prevent cell over-saturation and closure. All three products should be used in a similar manner.

The protocol is as follows; inject all products post workout, preferably after training large muscle groups which cause the most glycogen depletion, hence providing faster uptake of peptides. A sample layout is to inject Monday, Wednesday, and Friday.

Immediately post-workout inject 10-15iu of growth hormone IM, using a insulin pin and inject in any small muscle group such as delts, triceps, or biceps. Wait 20 minutes for the half-life clearance and conversion to igf to begin its sequence from the growth hormone and then inject a small dose of igf to create a synergistic super charge of the conversion process. I would recommend no more than 30mcg at this time. 10 minutes later you will take Humalog insulin only, and inject 5iu. I recommend starting with 5iu because Humalog has a very rapid onset and is easy to control with sugar. In conjunction with igf, you will be hyper-sensitive to insulin so start small and slowly work your way up to a maximum dose of 12iu post-workout. You will want to have around 80-100 grams of simple sugars such as dextrose and grape juice and an additional 60 grams of whey protein at the same time as your insulin. You will then eat another moderate glycemic index meal one hour after your high glycemic shake.

The reason for the high dose growth hormone is to take what would normally be your one week intake of gh and spread it out into 3 equal doses, injected pwo. This will create a truly anabolic rich environment and you will also benefit from full uptake due to your pwo depleted state.
So there is our post-workout regime, 3 days per week. Certainly you should take more than this, shouldn’t you? For most lifters, this protocol will be sufficient for growth. For someone with at least 6 months of gh use, 5 or more cycles of insulin and who no longer responds to typical igf protocols, the following regime may be followed: In addition to the above outline post-workout method, you may add additional doses of igf as well as insulin on the same day as your post-workout injection.

I would highly recommend you take 15mcg igf an additional two times per day. By taking less igf more often you will prevent cell over-saturation as well as receptor down-regulation. Creating a cell rich environment that saturates the cells infrequently will target massive cell proliferation. In addition you will take insulin 20 minutes after the igf on those 2 additional injections creating an anabolic rich environment that will last all day, 3 days per week.
For a sample protocol for someone that works out after work, I would recommend you do the following: Take 15mcg upon rising in the morning, followed by 10iu Humulin R or Humalog 20 minutes later. Immediately eat a carbohydrate rich meal with quality protein and low fat such as bananas, oatmeal and egg whites.
For lunch, take another 15mcg igf with 10iu insulin and have another moderate glycemic carbohydrate meal and protein with minimal fats. Follow the above listed pwo protocol to complete your three time injection schedule which will be used three times per week.

If you follow the outline laid out for you above to the letter, you will put on a massive amount of lean mass with a minimal amount of fat. You will need an anabolic and androgen rich environment to complete the schedule such as testosterone and tren in addition to the peptide products. T3 and T4 will not be necessary on this schedule as your thyroid levels will not be affected.


By: Gavin Kane

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Insulin-Like Growth Factor Recombinant 3

Insulin-Like Growth Factor Recombinant 3

IGF1 stands for insulin like growth factor. It mimics insulin in the human body and also at the same time makes the muscles more sensitive to insulin’s effects. It is a growth factor and is the most potent one in the human body at that. IGF causes muscle cell hyperplasia, which is an actual splitting and forming of new muscle cells. This was thought to only be possible during puberty. IGF is much more potent at this effect than growth hormone is, in fact almost all of the effects you see from growth hormone come from the increased amount of IGF that your liver produces when the GH is destroyed. So it would be very easy to say that IGF is a much more potent and cheaper alternative to GH use, although GH is more effective for fat loss than IGF due to some other effects that it causes such as metabolism increase and the ability to effectively use more insulin, T3, and anabolic steroids.

Another advantage that IGF has over GH is that it has much more of an affinity to attach to muscle cells instead of bone and organ cells. Growth hormone has been know to cause a lot of organ enlargement and bone elongation since it attaches to all types of receptor cells. IGF is much more likely to go where we want it, our muscle cells. IGF-1 attaches to myogenic stem cells which are only located in muscle and connective tissues. These myogenic stem cells are responsible for the production of myoblast cells which in turn are responsible for the buildup and repair of connective tissues (ligaments, tendons, cartilage, and joints to a certain extent).

So from this you can see that IGF-1 is great for increasing the strength of tendons and also for helping to heal existing injuries while at the same time helping to prevent them. IGF-1 is also responsible for increased protein synthesis and amino acid synthesis.

IGF does not have to be used along with anabolic steroids, GH, insulin, or thyroid hormones to be effective. It causes muscle growth on its own. In fact some people prefer to use it during their breaks from steroid cycles since IGF has no effect on natural test production. It could effectively be used along with HCG, clomid, and PGF2a for a hell of an off cycle stack which would allow your body to return to normal and still allow you to grow!! On its own IGF will give an increase of around 2 lbs. of new solid lean muscle tissue every two weeks, and is also is know for its ability to strip off body fat and GREATLY increase vascularity, body fat decreases of 5-8% over a 50 day cycle are not uncommon. But, of course you will be much happier with the results if you use the IGF along with anabolic steroids, testosterone, and insulin.

The use of steroids along with the IGF allow you to quickly mature and strengthen the new muscle tissue that the IGF has formed, and may also speed the process of hyperplasia. If you need any help setting up a great stack to
use along with the IGF just let me know and I can help you out. I speak with lots of top bodybuilders and guru’s so I am very knowledgeable.

The dosage issue for IGF is where the most controversy lies. Dosages used by competitive athletes most commonly range anywhere between 60mcg/day to 100+mcg/day. The trick is finding the dosage that works best for YOU. For most the best results appear when you reach a dosage of 80mcg/day, while some do
receive good results from only 40mcg/day. I personally feel the best results begin to be noticed at a dosage of 100mcg/day. I personally am using 150mcg/day during my current cycle.

Also I should let you know that the form of IGF is the Long R3 analog. It has been chemically altered and has a longer half-life than regular IGF, which only lasts about 10 minutes in the human body once injected. The Long R3 IGF-1 has a half-life of 6-10 hours, so you will only need to inject once or twice per day. The best time to inject is after lifting and in the morning, so it would be best to use half the dosage in the morning and the other half after lifting. This will take maximal advantage of IGF’s insulin
mimicking effects.

As posted by: WarLobo

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Peptide 6 - The Breakthrough Human Growth Hormone (HGH) Releaser

Peptide 6 - The Breakthrough Human Growth Hormone  (HGH) Releaser

Another exciting advancement in age management medicine! This peptide is now approved for general use as a substitute for Human Growth Hormone (HGH). HGH is known as the most effective medication to slow the aging process, but has had legal issues in the United States because of abuse. The strict limitations for using HGH are now avoided by using this new peptide (GHRP-6). HGH is a 191-amino acid peptide produced by the pituitary gland and regulated by two chemicals - Growth Hormone Releasing Hormone (GHRH) and Somatostatin (SST). Nutrition and exercise also influences its release. Once HGH is released, it carries out numerous functions in the human body. Under the influence of HGH, cells increase in both size and number, stimulating growth in the body's cells. It also has the ability to enhance the movement of amino acids through cellular membranes and increases the rate at which these cells convert amino acids into useful proteins. Muscle building and repair, as well as growing new neurons (brain and nerve cells), depend on the presence of adequate HGH. Cognitive decline with aging is due to the absence of adequate HGH. Fat loss with an increase in lean muscle mass has been found to occur even with small doses of HGH.

When does the body actually secrete HGH? The largest quantities are secreted at night while asleep. This is another important reason to get adequate sleep. GHRH (Growth Hormone Releasing Hormone) is responsible for the release of growth hormone while you sleep.

A most interesting part of all is that HGH has the ability to re-grow cartilage! Its use for degenerative joint disease has been mostly ignored and underutilized until now. Rehabilitating old injuries and fractures could be vastly improved with the use of HGH.

In our later years, the body produces less HGH, and its effects are profound. HGH is a great compound for muscle gains and fat-loss with its loss causing the weight gain and loss of muscle mass about which we all complain.

One word of caution: Do not buy HGH online and attempt to self medicate! The hormones sold online could easily be contaminated, toxic or worse and very dangerous to your health. And, using HGH lowers the thyroid output so it requires careful replacement with Thyroxine (T4), not T3. This is yet another reason to make sure you are in a program managed by a qualified practitioner.

Here's the BIG news! An improvement in HGH increase and regulation is now available. GHRP-6, a 28-amino-acid peptide that signals the human body to begin secreting HGH is now available for use in our age management programs. Use of GHRP-6 to release HGH has many very attractive health benefits such as:

o Decrease body fat
o Promotes collagen growth
o Stimulates growth of new bone
o Reduces excess weight gain
o Reduces Insulin resistance
o Reduces risk of Obesity (Adiposity)
o Stimulates the Immune system, particularly in older patients

Many bodybuilders and athletes have recently started using GHRP-6 in an effort to build more muscle and burn more fat. It is a critical part of the cycling they routinely do, particularly when preparing for a show or competition. GHRP-6 should be part of your age-management protocol, and prescribed by someone very familiar with all its properties and benefits.



By Dr. Lewis Stocks M.D., Ph.D.

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insulin & bodybuilding

insulin & bodybuilding

insulin

Your body releases insulin to dispose of unneeded sugar. While insulin is an extremely anabolic hormone (actually the most anabolic hormone known to man), there is a definite disadvantage with insulin spikes caused by too much sugar. insulin triggers energy stores to open up and helps to shuttle nutrients into storage areas. Adipose cells readily accept nutrients to be stored as bodyfat shortly after the introduction of insulin. insulin opens the 'doors' in adipose for bodyfat storage for a very short period of time. It takes a high level of insulin to force open the adipose doors.

insulin doesn't affect bodyfat storage as long as the insulin levels rise slowly and remain fairly consistent. Throughout the day, sugar consumption can spike insulin levels and induce bodyfat storage. Eating a high carb diet without sugars will cause a steady release of sugar into the system causing a high level of insulin release, but since the rate of release is steady, it does not trigger an 'open door' in adipose for bodyfat storage but provides an extremely anabolic environment as the benefits of insulin are realized. Complex carbs are a much bigger molecule than simple sugars. They have many sugars bonded together. To turn complex carbs into glucose, they must be broken down. There is a series of steps that they must undergo to be broken down. Enzymes must be present to break each molecular bond of these polymers. All this takes a while to complete. By the time some of it is broken down into glucose, in the small intestines, some of it has already passed into the large intestine where absorption is almost completely ceased. This process allows for a slow and steady rate of glucose production that fuels the brain and muscles throughout the day without causing a release of insulin. This is very important because, as previously stated, you don't want insulin in your body during a workout; you need its recipicle, blood sugars.

Animals release natural sugar stores, glycogen, for energy. The body will regulate itself with insulin when it no longer needs the sugar in its system. It doesn't matter whether the sugar comes from internal (from glycogen) or ingested sources (table sugar), insulin is released to counteract it. There will be rushes and fatigue with high consumption of sugars as your body tries to regulate itself. It can be almost impossible to workout when one's blood sugar levels are low due to sugar consumption beforehand.

insulin signals the body to begin repair after a workout. Your body thinks that glycogen has been released when sugar is present in the bloodstream. Why? Glycogen (blood sugar) is released when your body meets high output demands. After strenuous activity, the body has to repair. When one is undergoing activity such as weightlifting, he needs energy, glucose from broken down glycogen. insulin is released after the workout to counter the now not needed glucose level. When muscles sense the presence of insulin, they see that its time to begin healing and recuperation. insulin 'opens doors' in the muscles to accept nourishment and helps to shuttle in vital nutrients such as amino acids.

Just imagine your muscle cells as having an irresistible attraction to insulin, a chemical attraction. The insulin wants to get into the muscle. What is so significant about insulin is its chemical make up. Its structure causes it to bond to nutrients. Nutrients include creatine, prohormones, anabolic hormones, some vitamins, minerals, glutamine, and other amino acids. This is the cause of the 45-minute window for taking supplements and refueling your body for the nextworkout. The body sucks up needed amino acids during this period. Remember, muscle tissue is made from the assimilation of various amino acids. So, to have protein synthesis within the muscles, your cells must have sufficient amounts of various amino acids. Glutamine is the biggest component of muscle fiber. Adequate glutamine is essential for the addition of new muscle. All of these nutrients are sucked into the cell for 45 minutes due to the increased amount of insulin in the body after a workout, and because the muscles themselves are 'starving' for them, a phenomenon called intercellular thirst.

With this in mind, you can see how ingestion of huge amounts of sugars after a workout is beneficial. Your body will have some insulin naturally released after the workout but the more, the better in causing a hormonal environment that's good for forming new muscle. IGF-1 (insulin like growth factor), a Growth Hormone, is also released in the presence of insulin. Growth Hormone is what causes gigantism. That's one factor in determining why some people are mesomorphs and others are ectomorphs. It's why people like Andre 'the Giant' don't even have to work out to be huge, but if they do, they gain much more muscle than the normal person. The growth hormone is released by the pituitary gland.

Think about this, what if you could have a spiked insulin level all throughout the day? You've already learned that you don't want extra insulin just before a workout because it will hinder the breakdown of the muscle fibers. But imagine a 24-hour insulin spike. That would be the most anabolic environment one
could ever hope to achieve. So how do you achieve that? Well that's one of the biggest dilemmas faced in the underground world of competitive bodybuildingtoday. And in fact it's one of the biggest reasons that bodybuilders are bigger, stronger, and more defined than bodybuilders ten years ago. They have employed the injection of artificial insulin.

Imagine, all day long, almost everything that is consumed is converted into anabolic fuel. insulin is more powerful than any steroid ever formulated. But it's also the most dangerous. Bodybuilders inject incredible amounts daily. The pancreas may soon stop its own production of insulin and the body can become solely dependent upon the exogenous injections. One could cause himself to become a life long diabetic. They sell their health to the sport of bodybuilding.

Well, this should show you the importance of insulin in the bodybuildingworld. The main theme of insulin is: complex carbohydrates inadvertently cause a slow but steady release of insulin all day long. So, if you up your consumption of complex carbohydrates, you put your body into a more anabolic state without
artificial insulin.

Never drop carbohydrates from your diet no matter what you hear unless you want to end up fatter with more flab and less muscle than you did before you started your 'diet.' People have made millions because they get a degree and come up with a new 'diet' plan and sucker people into following it and inadvertently wreck their bodies in the long run. If you drop carbs, even though you consume vast amounts of protein, your body will not be as anabolic, and you will loose muscle. Cut back the fat from your diet and increase the complex carbs as high as you can. EAT EAT EAT. That's how you loose weight. Not that
everyone is looking to loose weight per se, but gaining muscle = loosing bodyfat. Muscle is the only mechanism by which to burn fat (except from heat that is produced through various means).

I'll reiterate upon one of the advantages of this 45-minute window. After strenuous activity, your body is more receptive for storing up energy as glycogen than any other time. Glycogen is not stored as fat. It's stored in the glycogen stores. Ingestion of sugar at this time will allow it to be stored as energy to be
consumed during the healing process as well as your fuel for the next day and the next workout.

The body is most receptive within 30 minutes of a workout. After 45 minutes, it begins to taper off drastically. The protein and carbs that you consume after a workout would be more beneficial for you if they were in a liquid form, such as a whey protein drink or meal replacement shake. Solid food must sit in the stomach and wait on digestion before it will be sent to the small intestine where the needed nutrients will be absorbed. It's a race against the clock. This is your critical time. About an hour to an hour and a half after a workout you can eat a good meal. To eat it before then will cause your sugars and proteins to have to sit in the stomach until the rest of the solid food can be broken down before it is absorbed. You don't want to hinder the absorption of liquid proteins and sugars. Also, casienate (a protein supplement) should be avoided at this time due to the fact that stomach acids cause this protein to gel and it takes considerably longer for your stomach to digest it.

Be careful not to ingest any sugars before your workout. You don't want insulin in your system during a workout. This is for obvious reasons. insulin depletes blood sugar. With low blood sugar, your can't make strong muscular contractions. You will be holding down your gas pedal for growth while you are holding down your brake for muscle breakdown. The only reason a muscle gets bigger is through the body adapting to stress by not only repairing the muscle from this breakdown, but repairing it to be MORE powerful than it was before.
author ???????????

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HGH Precursors

HGH Precursors

What these products actually provide you with is not in fact HGH, but the chemical 'precursors' to allow your body to manufacture more of it. Although the ultra-rich have for decades received actual HGH injections, this is extraordinarily expansive in every way, and not within the price range of most of us.

Then what are these 'precursors'?
They are proteins mainly, or amino acids that help the human pituitary gland create the hormone -   HGH. These basic building blocks are what you need to give your body as much of as it as what's properly possible, as well as providing the correct internal body environment (through sleep, exercise, and good eating habits) that will result in creation of more of this hormone.

While science is still catching up to discover what level these hormones play in keeping you young, it is clear that providing the building blocks is a step in the right direction.

HGH precursors have a greater effect the younger the person is, so starting right away with a supplementation plan is key, if you are interested in achieving these effects.

As to what these proteins actually are, read on!
Three of the most effective precursors include Ornithine, Glutamine, and Arginine, which are all types of "L" amino acids. Two of these, namely Arginine and Ornithine became known for their involvement in Growth Hormone production in a life extension book that appeared in 1987. As valuable additions to fat-loss and muscle development (body-building in this case), these two protein precursors have been given credit as significant parts of any hormone supplementation program.

One of the more common proteins in the human body, Glutamine has a great effect on HGH production. In medical trials, an increase in daily intake of Glutamine (just 2 grams) had effects in some of the test subjects that gave them over 400% more HGH measured in their blood stream – now that's a big increase!

Clinicaly approved research still has a long way to go before there is absolute proof through the federal science channels (as from the labs themselves), but as of right now, there ARE enough cases to prove that products like hgh are not only worth looking into, but worth the chance of them actually working for you. Think about it... how much is your youth worth?


written by ?????????

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Insulin explained as used in bodybuilding

Insulin explained as used in bodybuilding 

First let me preface by saying that insulin IS NOT for newbies.... gain weight with AAS first.... then try this.... This is an informative article, but it is not the end all. Research your ass off...
And finally.... I am not a doctor.... so use this as a guide....
Also I do not mind if this gets posted else where...

Insulin and all that it entails.

Chemical structure
Insulin is the hormone that is released by the beta cells of the pancreas. It is the hormone that regulates blood glucose levels. It is a polypeptide that is made up of a chain of 20 and 31 amino acids, thus a total of 51 amino acids. This nifty little hormone just so happens to be the most anabolic hormone in the body.

Actions of Insulin
In addition to its role in regulating glucose metabolism, insulin stimulates, lipogenesis (the formation of fatty acids from acetyl coenzyme in the living body), diminishes lipolysis, (the hydrolysis (breakdown) of fat). It also stimulates the uptake of amino acids contributing to its overall anabolic effect. We as bodybuilders should be interested in that. Insulin also modulates transcription, altering the cell content of numerous mRNAs. It stimulates growth, DNA synthesis, and cell replication, effects that it holds in common with the insulin-like growth factors (IGFs) (1)

For our bodybuilding needs
Our reason for using insulin is to use its ability to shuttle nutrients to the muscles at a very high rate. It shuttles large amounts of protein and sugars to the muscles for fuel, repair, and growth. The ability of insulin to transport nutrients is what makes it perfect for our needs and goals. More nutrients is simply more muscle mass. fast acting insulin for bodybuilding,

The use of Insulin for bodybuilding purposes
There are a few types of insulin available to the public, these I feel are the only ones that apply for our needs.
Humalin R*, Duration ~10-12 hours, peaks at 3rd hour until the 5th hour
Humalog* Duration ~6 hours, peaks at 80min to 120 min.
Nolvalog, Just a different maker of a fast acting insulin, same times as humalog.
Few notes, Duration is the amount of time the chemical is active.
Peak time, is the time in which you have the highest level of the chemical in the blood (2)

*This is for subcutaneous (subc, or subq) injections... we as body builders do not use insulin this way. We should and need to shoot intramuscularly (IM) see below.

Knowing what you know about the duration and peak times of humalog shot subcutaneous. Below is a graph to represent how humalog shot IM affects the blood glucose levels.

T= -5 is post w/o before insulin
T=0 is 10IU Humalog IM into left bicep
T= 5 is BG prior to my ingesting 85g of dextrose, 5g of glutamine and 7g of creatine
T=35 is BG prior to ingesting 80g of whey
T=105 is BG prior to 25g of dextrose and 150g of chicken breasts
After 150min past an IM Humalog injection, the BG remains stable

First off the warnings...
-Insulin is dangerous. Yes you can die from it, you can have some serious complications. But my goal is to educate you enough to where you never have to worry about these problems.
-Hypoglycemia- symptoms include disorientation, headache, drowsiness, weakness, dizziness, fast heartbeat, sweating, tremor, and nausea in NO particular order. This can and WILL happen to you... so be prepared.

How to use it for our needs...
Once you are finished with your work out, get the hell out of the gym to take your shot. Do not look around for a new girl to talk to.... get your ass home.
Once you are home, and this is your first time using it, start off with 4 IU. Every PWO there after add one more IU, until you hit 10iu.
Then follow the diet below

Diet-
10min after your shot, ingest  the proper amount of dextrose* and 65-90G of whey isolate protein in WATER
One hour after your shot have your PPWO meal. This meal is a solid one. (no shakes)
40-50g of protein, 40-50g of carbs, NO FATS
Also avoid fat at all costs for the next two and half hours. Remember if insulin transports AA and protein at a high rate, it will also transport fat**.... you have been warned

*You simple carb ratio should start off at a very safe, 10g of carbs per 1iu of insulin. So if you are at 7ius you need 70g of dextrose.

**But I don't want to get fat
- Hey neither do I.... so to avoid this complication once you get to your 10ius of insulin and everything is good. Lower your carb to slin ratio SLOWLY. Once you feel funny, you are too low. This varies from person to person... I feel hypo at 7g/iu.... some of my buddies can go 5g/iu. So proceed with caution whenever you try to figure this stuff out.


Supplements that IMO work very well when insulin is active.
AAKG (L-Arginine-alpha-ketoglutarate) 2g pre, and 3g with your shake.
CEE (creatine ethyl ester) 1g with your shake.

Things to remember-
-This HAS to be cycled 4 weeks on, and 4-6 weeks off. Otherwise your insulin sensitivity will go down and you could have some problems. This is where you could become insulin dependent...... bad news!

-Its a good idea to have a partner around that knows that you are on insulin... Just incase something happens then can be prepared to help you out.

-Have all of your supplies with you ready to go before you take your shot. I live close enough away from the gym where I can drive home and shoot at the house. But some of you do not have that luxury. So if you shoot in the car or in the locker room, make sure you have your dex/whey drink. Along with some sweetharts, dextrose tablets or even a soft drink. That way if you do come across a problem (going hypo) you can stop it before it really starts.

- Do not exercise while the insulin is active... it will throw off your glucose levels and cause you to go hypo a lot easier.

- Do not go to sleep whenever the insulin is active, seems like common sense to me but I just want to say it. If you are asleep... you have NO way of knowing if you are going hypo.... so STAY AWAKE!

- Do not shower while the insulin is active.... makes it very hard to determine if you are going hypo.... trust me I know
-Hypoglycemia can happen VERY fast... so make sure you are ready to fight it IF it happens.

Things you need to do prior to using insulin, once you feel you are ready.
-First you need to get a blood glucose meter... if you do not have one, do not mess with insulin, period
Second, once you get your BG meter, check your BG first thing in the morning when you wake up. This will be YOUR personal baseline. Test this for a few days to see what your levels are.
Third- It would be a good idea to eat like you would on insulin and check your BG PWO. You just have to check it once.... 15 min after your dex/whey shake is great.
These are just precautions.... I'm trying to save your butt here.

Some questions related to insulin-
-I can only get Humalin R in the states.... can I still use it?
Yes you can, do I recommend it? No way... did you forget what you just read If you want info on how to get humalog... shoot me a PM

-Can I get away with using an insulin pin to inject IM?
Sure you can, make sure you shoot into an area of low body fat. IE bis, tris and for some delts and quads.

-Can I use this to cut? Yes you can, but this is for an advanced user. Chances of hypo increase whenever this is done.
.

-Can I bulk with it? You bet you can.... and its EASY. Just up your carb intake to 12g+ per IU and you will be gaining in NO time.

-Can I use this in PCT?
shoot yeah you can and its a very good idea. This is a great way to keep some of the mass you have gained in your AAS cycle.

-Can I add supplements to my PWO shake?
Yes, I add 1.5g of CEE (creatine ethyl ester) as soon as I take my shot. Also you can use glutamine, but you need to split up your shakes.... so 5 min after injection, you have your glu+dex drink. 10min after that you have your whey iso drink. FWIW I do not use glutamine.

-Do I need to use insulin twice a day?
IMO no... the only time you have to have it is PWO. But some use it in the morning to fight of catabolism... If this is what you want to do, use a small amount ie 4-6iu.

Insulin use with LR3 IGF-1
I am writing this for the seasoned insulin and LR3 user
LR3 makes you more sensitive to insulin. So even if you know what your carb ratio should be.... up it. And lower your initial intake of insulin.
Start at 7iu, and with a 10g of carbs ratio.
Work up or go to 10ius... keeping your dex high.
Then lower it accordingly.
If you are using both, hypo comes way faster than it did before.... I have had to keep my carbs over 9g...
So just be careful.

Increasing your Insulin sensitivity
There are a few ways that you can go about to accomplish this, OTC or prescription.

OTC
-ALA any form of it but Kr-ala is the best, as it does not break down thanks to the potassium. The dosage is around 400mg-600mg... and add some biotin. For more on this visit the supp section....

-GTF Chromium or Chromium Picinolate at 300-400mcgs. This stuff is cheap so get some.

By prescription-
-Actos this med comes in 15mg 30mg and 40mg tablets... for the average person with lowered sensitivity, 15mg will be enough to bring it back to the normal range.

Blood Glucose Ranges (mg/dl)
Taken first thing on the morning (fasting for 8+ hours)
70 - 110 mg/dl - normal range this is individualistic.
110 - 126 mg/dl - impaired tolerance range. This means you need to monitor closely as becoming a diabetic is a problem.
126 - above mg/dl - You are a diabetic....

Types of Diabetes:
Type 1 Diabetes is caused by a total lack of insulin that, in turn, produces high blood glucose levels. Type 1 is most often is seen in children, but can develop in adults. If you have Type 1, It would be a good idea to have your blood sugar checked regularly.
Type 2 Diabetes occurs when the body does not produce enough insulin or cannot properly use insulin. This is the most common type. The treatment may be similar to Type 1.


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Mr. Sparkle

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Beginner’s Guide To IGF1-lr3

Beginner’s Guide To IGF1-lr3

The goal of this IGF1-lr3 guide is to help both those that have not used IGF-1lr3 before and for those that simply would like a methodical approach to the “mechanics” of running it. This guide does not expand on the biochemistry of IGF-1, aside from a very simple introduction to it. I suggest reading a book or searching forums to educate yourself about the biochemistry of “peptides” or “IGF” if you require in-depth knowledge.

I am not a physician, thus cannot and do not diagnose ailments or diseases and/or nor do I suggest that IGF-1 is a remedy for any illness or diseases. IGF-1 should be treated with much respect. It is research compound, thus you should use at your own risk.

Currently (05/31/2008), in the United States, IGF-1lr3 is a research compound. It is legal to own this substance to the best of my knowledge (at current time). I am not an attorney, so please review your local law(s) regarding possession and administration of this therapeutic protein.

I do not condone the usage of IGF-1lr3 unless you are qualified to do so. This guide is provided as a research & development tool only.

IGF-1lr3 Overivew

Background:
Long Arg3 Insulin-like Growth Factor-I (Long-R3-IGF-I) is an 83 amino acid analog of IGF-I comprising the complete IGF-I sequence with the substitution of an Arg for the Glu at position 3 (hence R3), and a 13 amino acid extension peptide at the N-terminus. Long-R3-IGF-I is significantly more potent than IGF-I in vitro. The enhanced potency is due to the markedly decreased binding of Long-R3-IGF-I to IGF binding proteins which normally inhibit the biological actions of IGFs.



Description:
Recombinant Human Long-R3-IGF-I produced in E. coli is a single, non-glycosylated, polypeptide chain containing 83 amino acids and having a molecular mass of 9111 Dalton.

0.6% Acetic Acid Overview

Acetic Acid (AA) will be used to reconstitute (turn your lyophilized IGF-1 into a liquid form) your IGF-1. The standard is to use 0.6% AA. This concentration is typically not available for you to purchase. You can make your own 0.6% AA and I will show you how below (many have used this method successfully).

Making 0.6% Acetic Acid
You will have to purchase a few items upfront. Here is a “grocery list” of items you will need. I have provided check boxes for you to check off once you have purchased these items.

Items Needed:
• Distilled white vinegar (grocery store)
• Distilled water (grocery store)
• 0.2-0.22um sterile Whatman syringe filter
• 10mL syringe with a luer lock tip
• ~20-22 gauge needles (just the needles)
• Sterile glass vial (10-20mL)
• Alcohol prep pads – sterile kind (70% isopropyl alcohol)


Quick Guide:
1. Swab the top of your sterile vial with alcohol prep pad (70% isopropyl alcohol)
2. Mix 7.5mL distilled water with 1.0mL vinegar
3. Add Whatman syringe filter
4. Add sterile ~20ga. needle to end of Whatman filter
5. Inject the 8.5mL of solution into the sterile vial
6. You now have sterile 0.6% acetic acid



Detailed Directions:
1. Wash you hands thoroughly
2. Optional: wear alcohol treated exam gloves (rub your gloved hands together with 70% isopropyl alcohol on them until dry)
3. Using a sterile alcohol prep pad, swab the top of your sterile glass vial (into which the acetic acid solution will be held in)
4. Using the 10mL syringe with a ~20ga. needle on the end, draw up 7.5mL distilled water
5. Using the same syringe, now draw up 1mL vinegar
6. Remove needle from the syringe and discard
7. Attach 0.2-0.22um Whatman sterile syringe filter (do not touch the free end that will have a needle on it)
8. Put a new, sterile needle (~20 gauge) onto the free end of the Whatman filter (do not touch needle)
a. Do not use the same needle on the Whatman that was used to originally draw up the unsterile vinegar and distilled water.
9. Put a ~20 gauge sterile needle into the top of your sterile glass vial to act as a vent
10. Inject the acetic acid solution into the vial
11. You are now done and should have sterile 0.6% acetic acid

Notes:
1. These items MUST be sterile: 20-22ga. Needles, whatman filter, glass vial
2. Whatman filter: These small, sterile filters are used to filter the acetic acid solution so it is sterile. It does not matter that the liquid in your syringe (distilled water & vinegar) is not sterile, nor does it matter that the syringe itself is not sterile. Once the liquid goes through the filter it is STERILE. Thus, everything after the filter must be sterile!
3. You will most likely use 1mL (milliliter) of 0.6% AA to reconstitute your IGF-1. Thus, you should make at least 1.5mL. In reality, it’s just as easy to make 8.5mL as I have stated in the above directions. You will have plenty for use later then.
4. Do NOT reuse the Whatman filter nor any needles! Discard immediately.




Reconstituting IGF-1lr3
Reconstitution is simply the addition of the 0.6% AA to your lyophilized IGF-1.
Assumption: 1mg/mL IGF-1/AA (1mg IGF-1 will be combined with 1mL AA; 1mg IGF-1 is the same as 1,000mcg)

1. Swab the top of your IGF-1 vial with a sterile alcohol prep pad
2. Swab the top of your 0.6% AA vial with a sterile alcohol prep pad
3. Using either multiple insulin syringe volumes (example: 2 x 0.5cc) or a single large syringe, obtain 1.0mL of 0.6% AA.
4. In the IGF-1 vial, insert a sterile ~20 ga. needle to act as a vent
5. Inject the 1.0mL of AA very slowly and dribble it down the side of the vial.
a. Be very careful with this peptide as it is very delicate!
6. Remove the needle & syringe and discard
7. Gently swirl the vial or roll between your hands.
a. Again, be very gentle here
8. You now have 1mg/mL of IGF-1
a. This is the same as: 1,000mcg/mL

Notes:
1. If you added 2mL of AA, it would be a 0.5mg/mL
2. I have an Excel calculator that will help you with these calculation.


Injecting IGF-1lr3
If this is your first time with injections, don’t worry. You will be using a very fine gauge insulin syringe which means you will most likely have nearly effortless injections. These things are so tiny and sharp you may not even feel it penetrating. If you use sterile procedure, aspirate prior to injection, and have diluted your IGF-1/AA solution with enough bacteriostatic water (BW), you should have no issues with your injections and very minimal post-injection discomfort (if any at all!).

I cannot stress enough the importance on two topics: A) sterility, and B) pre-injection aspiration. Always swab the injection site(s) with a sterile isopropyl alcohol (IPA) pad and aspirate prior to injecting the IGF-1. No questions asked!

You will most likely intramuscular (IM) injections, but subcutaneous (sub-q) injections are also followed by some, but current theory is that IM will yield a localized effect. By “localized effect”, I am referring to the effect IGF-1 will have at the injection site. So if you inject IM into biceps, it is thought that your bicep muscles will get more of a dose of IGF-1 than other parts of your body (some which you don’t want to be effected, such as the intestines). Both types of injections will have systemic effects (affecting the body as a whole). Long R3 IGF-1 has an estimated half-life of 20-30hrs (taken from IGTROPIN data).

This guide assumes you will be doing bilateral IM injections. More below.

Bilateral injections are injections that are evenly divided between two muscles. If you are injecting 40mcg (micrograms) bilaterally, you will be injecting 20mcg into the right bicep and 20mcg into the left bicep.

Current theorized best practice is to you inject your peptide post workout (PWO). You have a small window of optimal opportunity. Ideally, you would inject immediately PWO, but some do not like the idea of injecting in a public location, such as the gym. Your next best option is to make your way home ASAP and have your needles loaded and ready (with your alcohol swabs sitting near by).


Sterility
Without a doubt, sterility is a major concern with injections. You have to be conscious of bacteria and other infectious agents at all times when performing injections or other procedures that require sterility (such as reconstitutions and making 0.6% AA).

Bacteria (and viruses, and spores, etc) are invisible to the naked eye. Yet they are everywhere. It is very important that you acquire sterile alcohol prep pads (make sure it says “sterile” before you buy them). They are extremely cheap and effective.

Wash your hands! Before attempting anything requiring sterile technique, wash your hands and dry them with a clean paper towel (not the dirty towel hanging in the bathroom!). For optimal sterility, you may purchase exam gloves (latex or non-latex) and, after putting them on, you can dump some isopropyl alcohol (IPA) onto them and rub your hands together thoroughly. Now you really have sterile hands. Exam gloves are very inexpensive as is the bottle of IPA. IPA can be purchased for ~$1/bottle in the grocery store where the band-aids and whatnot.

I recommend you use a fresh syringe for each injection. Yes, some choose to use one syringe, but my feeling is that the syringes are so inexpensive and the risk of cross-contamination from one injection site to the other isn’t worth the risk. Furthermore, every time your syringe needle has to penetrate something (rubber stoppers in vials, skin, etc) it dulls the tip. Thus, maximum comfort is also achieved with fresh syringes.

This topic of “one or two syringes” can be argued, but if it’s your first time, play it safe and get off to a great start by using 2!

Pre-injection Aspiration
Pre-injection aspiration is what you do after the needle has penetrated the muscle. You must gently and slightly pull back on the needle’s plunger to see if you have hit a vein/artery.

Either of two things will happen upon aspiration: A) bubbles/air and/or clear liquid will appear in the syringe (this is good), or B) blood will appear (bad).

If A) occurs, proceed with your injection. If B) occurs, then simply withdraw the needle, and re-pin a different location in that same muscle. You do NOT want to inject your solution into a vein/artery! This may result in very serious consequences. Don’t worry, you can avoid this by simply aspirating slightly. Have faith in yourself.

Injection Procedure
First, do not get all worked up over injecting IGF-1. Easier said than done, I know. But the reality is, the insulin syringes are extremely gentle. Also, millions of people around the world, including women and children, use these syringes daily to treat Diabetes. So you know it can’t be that bad (seriously)! I highly recommend watching a couple videos on youtube regarding intramuscular (IM) injections to get a general idea of how they’re done if you’ve never witnessed them!

Back-Loading With Bacteriostatic Water (BW)
Back-loading is a process in which you dilute the IGF-1/AA solution that is in your syringe. The point is to dilute the acidity to a point that it will no longer cause tissue necrosis (death/damage) or pain upon injection. It is recommended to dilute no less than 4:1 (4 parts BW to 1 part IGF-1/AA).

Example: If you are injecting 40mcg bilat, IM, you will have two syringes each with 20mcg IGF-1. Assume you want to draw 2 IU IGF-1. You will draw 2 IUs of the IGF-1/AA solution, then draw 2x4 = 8 IUs of BW (four times the amount of IGF-1/AA solution). The total number of IUs in each syringe will be 2 + 8 = 10 IUs. It will not hurt you if you decide to back-load with more BW. It is a personal preference.

***Use my Excel-based “IGF-1” calculator to determine how many IUs you will need for a particular insulin syringe (1cc, 0.5cc, 0.3cc).

Recommended Best Injection Method: Injecting bilaterally, post workout, intramuscularly (Bilat, PWO, IM)



Items you will need
1. Alcohol prep pads
2. 2 insulin syringes
3. Bacteriostatic water (BW)
4. Optional: exam gloves
5. Optional: IPA (to rub gloves with and to clean the surrounding area)

Injection Directions
1. Wash your hands thoroughly
2. Optional: put on exam gloves and rub with IPA until dry
3. Using an alcohol swab, clean the tops of both the IGF-1 vial and the BW vial.
4. Using a fresh alcohol swab, thoroughly clean the injection sites (let dry)
5. Fill each syringe with the appropriate amount of IGF-1/AA solution
a. Do NOT touch the needles to anything but sterile surfaces!
b. It is recommended that you clean/sanitize the area/surfaces you’re working in, in case you mindlessly touch a needle to a table (or other area).
6. Back-loading: Draw up the necessary amount of BW into each syringe.
a. Tilt the needle up and down so the bubble(s) rise and fall, which mixes the solution slightly
7. With the needle pointing up, flick the syringe body to get the bubbles to rise to the needle
8. Slowly expel the air; be careful to not quirt liquid out as this wastes IGF-1
a. It takes >3mL of air to cause harm; small volumes of accidentally injected air will most likely be absorbed by muscle tissue
9. Insert syringe and aspirate by slightly pulling up on the plunger to see if you have hit a vessel. If you see blood, remove needle, and try again (no need to change syringes). If you do NOT see blood, proceed to inject.
10. Perform “7.” thru “9” above on other side.
11. Discard sharps in appropriate container



Glossary

Acetic Acid (AA): An acid that, when diluted to 0.6%, will act as a preservative for your IGF-1. An off-the-shelf version of 5% AA is distilled white vinegar; your IGF-1 may be supplied in acetic acid (usually 0.6%)

Aspiration: The technique of checking to see if your inserted needle is in a blood vessel. It is performed by gently pulling up on the syringe plunger until you either see bubbles/air/clear liquid, or blood. If you see blood, remove needle, and re-try the insertion.

Back-loading: The process of diluting your IGF-1/AA with bacteriostatic water, prior to injection. The purpose is to dilute the acidity of the AA so it doesn’t cause tissue damage and so it doesn’t cause injection burn/discomfort.
A. Draw desired amount of IGF-1/AA solution
B. Back-load with BW: draw desired amount of BW

Bacteriostatic Water (BW): This is water for injection (sterile) that has benzoyl alcohol (BA) added to it to ward of contamination. You use BW to dilute your IGF-1/AA solution prior to injection (aka, “back-loading”).

Bilateral Injection (bilat): An injection which involves the administration of IGF-1 in equal amounts to each side of the body. If you are injecting 40mcg IGF-1 into the biceps bilaterally, you will be injecting 20mcg into each bicep (left & right side).

Distilled Water: Has virtually all of its impurities removed through distillation. Distillation involves boiling the water and then condensing the steam into a clean cup, leaving nearly all of the solid contaminants behind. This is NOT sterile water. It can be purchased in any grocery store in the “water” isle.

Endogenous: Substances that originate from within an organism, tissue, or cell. It is the opposite of exogenous

Exogenous: Refers to an action or object coming from outside a system. It is the opposite of endogenous.

IM: Intramuscular; typically refers to the type of injection where you inject a substance directly into muscle tissue

IGF-1 lr3: A peptide that is responsible for new muscle tissue development; it is synthetic and has a much longer circulatory life than endogenous IGF-1

Lyophilized: The form in which IGF-1 is typically supplied; this is a freeze-dried protein which is performed in a vacuum; appearance may range from a fine, loose white powder, to a white solid “paste”-type substance

PWO: Post Work Out; refers to the time period when the administration of IGF-1 is thought to be the most effective (immediately PWO).

Reconstitution: The addition of 0.6% acetic acid to lyophilized IGF-1r3 to get it into solution. Typically one reconstitutes using 1mL or 2mL of acetic acid, yielding 1mg/mL or 2mg/mL of IGF-1/AA.

Sub-q: Subcutaneous; typically refers to the type of injection where you inject a substance under the skin; this results in systemic distribution of substances


Author: PapaPumpSD

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