Showing posts with label CJC-1295. Show all posts
Showing posts with label CJC-1295. Show all posts

Peptide Combinations Guide


Peptide Combinations Guide

 
Growth Hormone (GH) and IGF-1 are naturally occurring hormones in the human body responsible for many enviable aesthetic traits such as muscle mass, leanness and a firm/even skin tone. As people age, levels of growth hormone rapidly decline and this is one of the main reasons humans put on weight, lose muscle mass and develop sagging/uneven skin. It's no surprise then that synthetic Human Growth Hormone is a sought after product for anti-aging by persons looking to remain youthful, bodybuilders looking to put on muscle mass and people in general who are looking to "tone up" or lose stubborn belly fat.


It is important to note that the products mentioned on this website are not the actual synthetic HGH (although HGH Frag 176-191 is the part of the "real" HGH which contributes to fat loss only). But in many respects these peptide analogues are far superior to the HGH 191aa drug for 3 reasons:
Actual HGH is very difficult or impossible to obtain in most countries and is one of the most faked/counterfeit drugs sold online.


If HGH can be obtained legally from a physician for anti-aging it's extremely expensive, with 10iu (units) costing as much as $200USD. As a comparison, the 10iu equivalent of GH releasing peptides (approximately half of one vial) sells online for approximately $20USD, a full 90% cheaper than actual HGH for the same, if not better, positive effects on the body.


Since actual HGH shuts down the body's natural pituitary gland, when you stop injecting it, your body's own ability to produce Growth Hormone is hindered and you will suffer a rebound of negative side effects such as fat gain, muscle loss and loss of skin tone/elasticity. This means you may end up doing yourself more harm than good. Since GH releasing peptides only stimulate your body's own natural production, there is no rebound negative effects if you stop usage.


The following guide indicates the best way to combine different peptides depending on your experience level of diet/training and also your goal:


Fat Loss
Muscle Building
Anti-Aging


As a general introduction, you should understand the different classes of peptides as this largely determines their combinations:


Growth Hormone Releasing Hormones (GHRH): include Modified GRF 1-29 and CJC-1295 DAC, are peptides which stimulate the pituitary gland to release stores of the body's natural Growth Hormone (GH).


Growth Hormone Releasing Peptides (GHRP): include Ipamorelin, GHRP-2 and GHRP-6, peptides which stimulate the release of a hormone called "Ghrelin" in the stomach, which then in turn causes GH to be released. GHRP's cause a much more significant release of GH than do GHRH, meaning that mg for mg, a peptide like GHRP-6 is three times more potent than Modified GRF 1-29. However, when taken together, they become approximately ten times more potent than either one alone.


IGF-1 Peptides: include IGF-1 LR3 and IGF-1e (also known as MGF or Mechano Growth Factor). IGF-1 is responsible for many of the positive effects of GH on fat loss and muscle building therefore they offer a good addition, especially if your goal is to build muscle, as they are both responsible for creating new muscle cells which can hypertrophy (get bigger) through weight training.


HGH Fragment 176-191: is a peptide which does not stimulate the release of GH but is instead a piece (or "fragment") of the full synthetic 191aa HGH molecule. More importantly, it is the fragment of GH which is responsible for fat loss, meaning it gives all of the fat loss benefits without any side effects.


As a general rule, regardless of your goal, if you are just looking to take one product, with the least amount of fuss and injections as possible, then it should be CJC-1295 DAC at 2mg (1 vial) per week. Due to its long half-life it causes your overall level of GH (Growth Hormone) to rise, and you will therefore see some improvements in things which go along with having higher levels of GH and IGF-1 such as improved body shape, sleep, skin and general wellbeing (although it can make you tired for the first 1-2 weeks while the body adjusts). Your dosage can be taken as just one injection per week (note that you may notice a head rush/flushing for 15-20 minutes after your injection due to the release of GABA in the body, a sign the product is working).
For information about more intricate and advanced usage of GH peptides please read on.


Fat Loss


The most potent weight loss peptide is HGH Fragment 176-191 which is the part of the Growth Hormone molecule responsible for fat burning. In HGH Frag Studies, it has been proven to reduce body fat, particularly in the abdominal area. The second most potent fat loss peptide is CJC-1295 DAC since it causes the overall GH level to rise in the body (the opposite of what happens naturally as a person gets older, which is why people tend to put on weight as they age). If your only goal is fat loss, it's often best to avoid the use of GHRP products (GHRP-6, GHRP-2 or Ipamorelin) since they can stimulate hunger and/or raise cortisol, both of which can be counterproductive to fat burning.


Diet Considerations


For GH to exhibit its fat burning effects, insulin must NOT be present. Insulin release in the body is caused mainly by consuming carbohydrates, although all types of macronutrients (carbs, fat and protein) still cause the release of insulin to some extent. Since HGH Frag works by causing the body to break down and release stored fat for use as energy, if you have recently consumed calories (food or beverage) your body will just use that for energy instead and little extra fat will be burnt. If however there is no food present for the body to use as energy, it will use the stored fat which the HGH Frag has caused to be released and you will notice reductions in body fat over the ensuing weeks.


Due to CJC-1295 DAC's long half-life the timing of meals is not important and this is what makes it an appealing addition to HGH Frag 176-191 to accelerate fat loss. To get the most out of your peptide usage for fat loss, the following guidelines should be followed:


Avoid eating/drinking anything with calories for three (3) hours either side of your injection.
Try to make all your meals throughout the day high protein, low fat and low carbohydrates (eg. meat/fish with vegetables/salad).
Have as few meals as possible during the day as periods of fasting have been shown in many studies to improve fat loss and also longevity (i.e. eating less will make you live longer).


Sample Peptide Cycles


Beginners


HGH Frag 176-191 at 250-500mcg per day.


Advanced


HGH Frag 176-191 at 250-500mcg per day + CJC-1295 DAC at 300mcg per day or;
HGH Frag 176-191 at 250-500mcg per day + Modified GRF 1-29 at 100-300mcg per day (split into dosages of 100mcg)


Example Injection Routines


Example 1 - Night Time Injection (recommended)
Ensure you do not eat or drink anything containing calories within three (3) hours of going to bed (with the exception of water, diet sodas, coffee/tea with artificial sweeteners).
Take your HGH Frag 176-191 injection just before getting into bed and your body will therefore be burning stored fat for the duration of your sleep.
If possible, do some cardio first thing in the morning and wait as long as possible before having breakfast to allow the fat burning to continue throughout the morning/day.


Example 2 - Morning Injection
Wake up and inject your HGH Frag 176-191 (250mcg to 500mcg is a good dosage depending on your budget).
Wait as long as possible before having your first meal (the longer you wait the more fat you will burn).
When you do eat, try to make the meal high protein, low fat and low carbohydrate (example meat and salad/vegetables).
If possible, try to do some cardio in the hours after your injection to increase the fat burning effect.


Note: If you are a person concerned about loss of muscle mass, you can consume a small amount of protein every 2-3 hours (amino acid tablets such as EAA and BCAA are good for this purpose and can be purchased from any health food shop or ordered online). However there is little reason to be concerned about muscle loss because when fat is available for energy, such as following HGH Frag 176-191 injections, protein and therefore muscle mass are spared.


Adding CJC-1295 DAC
You can add CJC-1295 DAC at 2mg once per week (or 300mcg each day along with your HGH Frag 176-191 injections - they can be mixed in the same syringe without any issues). You should take a break from CJC-1295 DAC every few months to give your pituitary gland a rest at which time you can continue to use HGH Frag 176-191 on its own, or you can substitute the CJC-1295 DAC with the short acting Modified GRF 1-29 at 100-300mcg per day (split into injections of 100mcg).


Muscle Building


Growth Hormone (GH) exhibits its muscle building effects mainly after its conversion to IGF-1 (Insulin-Like-Growth Factor). This makes IGF-1 an ideal choice of peptides for muscle building, especially since the IGF-1 LR3 version has an extended half-life which allows it to remain active in the muscles for many hours to complete its muscle building stimulatory effects. Likewise, if injected after a workout, the IGF-1 variant Mechano Growth Factor (also known as MGF or IGF-1e) is known to multiply muscle cells and contribute to muscle development. Furthermore, since IGF-1 is a by-product of GH, any peptide which increases levels of GH in the body such as a GHRP product or CJC-1295 product will obviously lead to increased lean muscle mass.


Diet Considerations
For Growth Hormone (GH) to perform its anabolic (muscle building) affects it requires the presence of the body's most anabolic hormone: insulin. This is in contrast to GH related fat loss which requires insulin to be absent. However, since GHRP and fast-acting GHRH (Growth Hormone Releasing Hormone) products (i.e. Modified GRF 1-29) still need time to stimulate the body to release GH from the pituitary gland, the insulin spike must come after the injection and not before, otherwise the GH release will be blunted.


The only exception to this is of course CJC-1295 DAC since it's long-half life and continual release of GH means it is not affected by food timing.
To get the most out of your peptide usage for muscle building, the following guidelines should be followed:


If injecting just a GHRP or GHRH product on their own, avoid eating/drinking anything high in fat for 3 hours before your injection and anything high in carbohydrates for 2 hours before (i.e. always do your injection on an empty stomach), otherwise the amount of GH release they cause may be significantly blunted leading to poor results.
If injecting both a GHRP and GHRH together (e.g. 100mcg of both GHRP-6 and Modified GRF 1-29) studies have proven that their ability to release GH returns to full-strength as little as 1 hour (60 minutes) post-meal. This gives users greater flexibility with their meal timings, especially since consuming sufficient calories is so critical to building muscle.
Whether injecting GH peptides alone or along with others, always wait at least 20 minutes after your injection before consuming anything. Once at least 20 minutes has passed, consume a food/beverage high in protein and/or carbohydrates to stimulate an insulin spike (if you inject in the morning and around your workout, this meal/shake should be high protein and high carbohydrates, if you inject at night this consumption should be protein only as protein is sufficient enough to spike insulin, but without the negative impact on fat gain which carbohydrates can contribute to).


Sample Peptide Cycles


Beginners


CJC-1295 DAC at 2mg per week or;
GHRP Product (GHRP-6, GHRP-2 or Ipamorelin) at 200mcg once per day.


Intermediate


GHRP Product at 200mcg + Mod. GRF 1-29 at 100mcg (2 times per day) or;
GHRP Product at 200mcg + CJC-1295 DAC at 100mcg per day (2 times per day).


Advanced


GHRP Product at 200mcg + CJC-1295 DAC at 100mcg (2 times per day) + IGF-1 at 50mcg after workouts or;
GHRP Product at 200mcg + Mod. GRF 1-29 at 100mcg (2 times per day) + PEG-MGF at 200mcg after workouts.


Example Injection Routines


Beginners


CJC-1295 DAC
2mg taken once per week, at any time of day.


GHRP + GHRH (once per day)
Inject your dosage (ensuring you have not consumed any food/beverages for at least 1 hour before, an optimal time would be first thing in the morning).
Ingest a protein only or protein and carbohydrate meal afterward to create an insulin spike.
Do weight training in the hours afterwards.


Intermediate


GHRP + GHRH (twice per day)
Inject your GHRP + GHRH peptides together in the same syringe (ensuring you have not consumed any food/beverages for at least 1 hour before, an optimal time would be first thing in the morning).
Ingest a protein only or protein and carbohydrate meal afterward to create an insulin spike.
Do weight training in the hours afterwards.
at least 1 hour after your dinner (or last meal of the day), take your second GHRP + GHRH injection.
If you are trying to control your body fat then have a protein only meal 20-30 minutes afterwards, otherwise a protein/carbohydrate meal will create a better insulin spike.


Advanced


GHRP + GHRH + IGF-1
Follow the same routine as shown above for "intermediate" persons. However, as soon as possible after your weight training you should also inject 200mcg of PEG-MGF (IGF-1e) and/or 50mcg of IGF-1 LR3 preferably into a muscle (although due to the long half-life of both products, sub-q injections are also acceptable). If injecting intramuscularly, you should make sure that the muscle you are injecting into is not covered by a thick layer of fat. Usually due to the length of insulin syringe needles, injections are therefore limited to the biceps for most persons.


While GHRP + GHRH can be injected each day with great benefit, even if you don't do weight training on that day. On the other hand, IGF-1 LR3 and MGF injections should be reserved for post-workout only.


Anti-Aging


For the Anti-Aging crowd, we recommend choosing only 1 peptide, rather than a combination. The reason for this is that as you get older your GH levels decline rapidly and therefore you will benefit from any kind of GH increase meaning there is no need to overdo things with multiple peptides. If you wish to use more than one peptide, we recommend cycling a GHRP product (GHRP-6, GHRP-2 or Ipamorelin) every 3-6 months with CJC-1295 DAC for two reasons.


The first reason is that CJC-1295 DAC is a GHRH (growth hormone releasing hormone) acting directly at the pituitary, while GHRP products indirectly stimulate GH by causing the release of Ghrelin. Rotating the products would therefore ensure one method of GH stimulation does not get "worn out" from repeated exposure to the peptides. The second reason is that even though CJC-1295 DAC has been proven safe in much higher dosages than we recommend, since it causes a continual GH release (GH bleed) no one can be certain how continual use would affect the pituitary in the long-term, so it's a case of being "better safe than sorry" and never using it for longer than 6 months at a time without a break.


Diet Considerations


For CJC-1295 DAC there are no particular diet restrictions that need to be followed due to its long half-life. For GHRP products the following should be observed as insulin and fatty acids can blunt the release of GH in the body and therefore make your injections less effective:
Avoid eating/drinking anything high in fat for 3 hours before your injection and anything high in carbohydrates for 1-2 hours (always do your injection on an empty stomach).
Wait at least 20 minutes after your injection before eating/drinking anything with calories.


Injection Amounts


CJC-1295 DAC taken at 2000mcg (2mg) once per week or;
GHRP Product (GHRP-2, GHRP-6 or Ipamorelin) taken at 200mcg per day.


Example Injection Routines


CJC-1295 DAC
2mg taken once per week, at any time of day.


GHRP-2, GHRP-6 or Ipamorelin


Example 1 - Night Time Injection (recommended to reduce possible tiredness during day).
Ensure you have an empty stomach (i.e. 2-3 hours since your last meal).
Inject your GHRP peptide and go straight to bed.


Example 2 - Morning injection
Take your injection of the GHRP product first thing in the morning at 100mcg.
Wait at least 20 minutes before having breakfast or any beverages (including coffee/tea).
(All info gathered via internet)


More Peptide Info...




GHRP-6; CJC-1295 reconstitution values


Peptide reconstitute methods:
It seems ghrp 6 and cjc-1295 are the most used peptide combos, and there are many good peptide info sites online. I have a very nice one pinned here. For some reason though its as if people can’t find a way to print in plain english and without confusion how to reconstitute from powder these two very popular products. I will also explain how we reconstitute hcg by iu. It’s very simple…

There are 1000mcg in 1mg so if you have 1mg of peptide and you add 1mL of BAC water you will have 1mL containing 1000mcg of peptide.

Take 5mg and add 1mL of BAC, you have 5000mcg of peptide in that 1mL of BAC.

So here is your reconstitute for 5mg ghrp-6 and 2mg cjc-1295:

5mg ghrp-6 vial:

reconstitute with 2.5ml of bac water = 2000mcg per 1 mL = each 10marks (each little line)or 10 units on a 100 unit(1mL) slin pin = 200mcgs or 5 ticks (5 units)= 100mcg

Note:*if you wish to use 5mL BAC water you will probably need to add 2.5mL, let powder disolve then add to a 5 or 10mL sterile multiuse vial then add another 2.5mL of BAC. Gives you 1000mcg/mL or 5 ticks= 100mcg.

 *Most peptides come in 3-4mL vials(max volume)

2mg CJC-1295 vial:

reconstitute with 2mls of bac water = 2000mcgs per 1ml = each 10mark on the slin pin = 100mcgs
Note: if wanting to use 5mL of BAC water you use the same method as above with ghrp.
 If using 5mL then 10 ticks on slin pin=50mcg

More Peptide Info...




About CJC-1295


CJC-1295 was developed for clinical trials in the year 2000. The drug was originally synthesized to remove visceral fat deposits in AIDS patients. CJC 1295 was ultimately successful on all research subjects, as increasing the level of growth hormone in the body proved to increase fat loss.
 Various experiments have been conducted to test the effectiveness of CJC-1295 in vivo and the Journal of Clinical Endocrinology & Metabolism has reported dose-dependent increases in mean plasma GH concentrations by 2-10 fold for more than 6 days and increased IGF-1 concentrations 1.5-3 fold for 9-11 days after a single injection
.

 Not only that but they proved the mean half life to be 5.8-8.1 days and after multiple doses showed mean IGF-1 levels remained above baseline for up to 28 days following! No serious adverse reactions were reported in any group.

 Another very positive benefit of CJC-1295/CJC-1293 is its ability to promote slow wave sleep. Slow wave sleep is also known as deep sleep and is the portion of sleep responsible for the highest level of muscle growth and memory retention. SWS are decreased significantly in older adults and also with people who tend to exercise later in the evening.

 This peptide has a benefit to side effect ratio that exceeds all others currently being legally sold and would make a great addition to ones training regimen or post cycle therapy.

CJC-1295 has the ability to make the body produce its own GH as compared to using synthetic HGH.  GHRP-6 in conjunction with CJC-1295 is synergistic, amplifying the GH pulse considerably. Studies have shown that CJC-1295 also promotes slow-wave sleep, the kind of sleep responsible for muscle growth and increased memory retention.

 There are three popular and clinically proven GHRH analogs on the market today, CJC-1293, CJC-1295, CJC-1295 DAC, and Sermorelin. CJC-1293 is a longer lasting peptide- it is sometimes also referred to as tetrasubstituted GRF(1-29) or Modified Sermorelin.

 The half life of Research peptide CJC1295 is more desirable and establishes a significant enough of a GH pulse to increase IGF-1 levels and GH levels. However, it's pulsatile release is more of a sustained-consistent release that does not necessarily mimic that of the pituitary gland.

 The CJC-1295 & the total 24 hour dosing of GHRP-6 together comprise a single comparison with exogenic GH administration.


More Peptide Info...




Basic peptide guide

Basic peptide guide


Peptide Information

Insulin-like Growth Factor LR3 (IGF-1)


IGF-1 LR3 Dosage(Long R3 IGF-1):
Light: 25 mcg
Common: 50 mcg
Large: 100 mcg
IGF-1 is administered for one month, give or take a week.
Insulin-like Growth Factor (Long-R3 IGF-1), an 83 amino acid analog of IGF-1 is a highly anabolic hormone released primarily in the liver with the stimulus of growth hormone (HGH).

IGF-1 is the most potent growth factor found in the body and causes muscle cell hyperplasia.
Freeze dried (lyophilized) IGF-1 (in powder state) should be stored in the freezer (-18 degrees Celsius).
Example Long r3 IGF-1 kit contains:
1000mcg of lyophilized (freeze dried) Long R3 IGF-1
2 mls of 0.6% Acetic Acid (AA)
30ml Sodium Chloride (NaCL) as buffer
Dilute the IGF-1 peptide with 2mls of Acetic Acid (.6%). Assuming (*DO NOT ASSUME*) Acetic Acid (AA) will yield the correct pH balance of your research peptide.
Note: This creates a concentration of 500mcg/ml. So each 1/10 of a ML is 50mcg’s.

Draw the desired amount of IGF in to a syringe. Desired amount should be the approx. dosage wanted.
Example- 2mls AA used to reconstitute IGF-1 1mg vial means 5 units on a U100 insulin syringe would equal 25mcg IGF-1 LR3
Pre-load your syringes at 5iu (25mcg IGF-1). Divide your IGF-1 into 40 syringes for storage in the freezer.
Thaw prior to administration. Draw from your NaCL after thawed to buffer (.5ml is enough).

Unknown whether injecting IGF-1 to increase muscle growth is efficacious. Many believe in the value of this powerful growth factor.
It is possible to go into hypoglycemia fro IGF-1 supplementation. Effect is dose dependent.

(information in this thread gathered via the internet)


Melanotan peptides, PT-141, CJC-1295, GHRP-6, IGF-1 LR3, GH fragments, come in the form of freeze dried powder using Bacteriostatic Water (BW) for reconstruction and preservative. Research peptides are supplied in multiple-dose vials from which repeated withdrawals may be prepared for subcutaneous injection (administrated intramuscularly in rare instances).

 Melanotan 1 - Melanotan is a synthetic (potent) version of melanocyte stimulating hormone (a-MSH). Afamelanotide treatment induces skin pigmentation through melanogenisis, the production of melanin. Melanin prevents cellular damage in the skin by absorbing, reflecting and refracting light. Melanotan reduces sun damage to UV exposed skin in those with sun allergies.

Melanotan 2 - Melanotan II is a cosmetic product that stimulates a natural increase in melanin production. Melanin is the main determinant of skin color in humans, a brown pigment which causes skin to become darker in appearance, instead of red, when exposed to UVR. Users of Melanotan II develop a gradual, natural tan with minimal sun exposure. Melanotropins useful for all skin types, particularly fair-skinned (Fitzpatrick skin type 1 & skin type 2).

Bremelanotide (PT-141) - Unexpected sexual arousal experienced by Melanotan 2 tanning trial subjects led to development of Bremelanotide PT-141. PT-141 does not act upon the vascular system, but the nervous system (cacading direct from the brain). Bremelanotide results are the world's only synthetic aphrodisiac developed after Melanotan 2 (MT-II).
 
GH Releasing Peptide-6 - GHRP 6 is a synthetic hexapeptide (six amino acid peptide) that releases growth hormone release. High levels of growth hormone have been associated with fat loss, muscle gain, general well being and anti-aging effects. Ghrelin effect from GHRP-6 can cause hunger. Ipamorelin, Hexarelin and GHRP-2 also bestselling GHRP research peptides.

GHRH (CJC-1295) - CJC-1295 (GHRH) continuously elevates Human Growth Hormone (HGH) and IGF-1. In the healthy body, large amounts of growth hormone are stored within the pituitary. CJC-1295 DAC has been proven to stimulate slow wave sleep helping restore the body. Research Sermorelin, CJC-1293, CJC1295, Mod GRF 1-29 (best) research peptide.

 Insulin-like Growth Factor LR3 - Insulin-like Growth Factor (Long-R3-IGF-1), analog of IGF-1 is a highly anabolic peptide released primarily in the liver with the stimulus of growth hormone. IGF-1 LR3 and IGF-1 DES popular glucose disposal agent analog peptides sold online. Dosage for IGF1 LR3 unspecific, whereas quick acting IGF DES pre-exercise administration recommended.

 191AA Growth Hormone (HGH) - Human Growth Hormone (rHGH, HGH, or GH) is a protein molecule consisting of 191 amino acids. Genetically engineered recombinant growth hormone is completely identical to the growth hormone made by the human pituitary gland. Growth hormone helps body composition and is rapidly converted to its powerful growth promoting metabolite, Insulin like Growth Factor (IGF-1).


 PEPTIDE INFO


Peptide Information


Peptides come in the form of lyophilized (freeze dried) powder. The amount of powder/product is stated in International Units (IU's) or in Milligrams (MG).
Melanotan peptides (Melanotan 1 & Melanotan 2), PT-141 Bremelanotide, GH Fragment, Ipamorelin, CJC-1295 & GHRPs (GRHP-2 & GHRP-6), HGH, HCG, et cetera use Bacteriostatic Water (BW). Bacteriostatic Water for injection, USP is a sterile, nonpyrogenic preparation of water for injection containing 0.9% of benzyl alcohol added as a bacteriostatic preservative. It is supplied in a multiple-dose container from which repeated withdrawals may be made to dilute or dissolve drugs for injection. The pH is 5.7 (4.5 to 7.0)

For IGF use an acetic acid solution (.6%) which is 7 parts distilled water and 1 part vinegar to reconstitute. You must filter the distilled water and white wine vinegar through a sterile 20 micron syringe filter before use. Sodium Chloride (NaCl) is used to buffer the injection.

1.) Take an alcohol swab to the stopper of both your peptide vial and the vial of the diluent.

2.) Draw your preferred diluent (BW) with a 1cc syringe. Choose an amount that will make measuring the final product simple.

1ml(cc) per 10 mg vial of Melanotan would mean each 10 tick marks on a U100 slin syringe would equal 1mg of Melanotan
1ml(cc) per 10 IU vial of HGH would mean each 10 tick marks on a U100 slin syringe would equal 1 IU of HGH

3.) Take the syringe with the diluent and push it into the vial of lyophilized powder letting the diluent dissolve the peptide. Many (not all) peptides are sealed with vacuum pressure, be careful.

4.) After diluent has been added to the vial, gentling swirl the vial until the lyophilized powder has dissolved and you are left with a clear liquid. The peptide is now reconstructed, ready for measurement and usage.
5.) Store your now reconstituted research peptides in the refrigerator.
Peptide Measurement
After successfully reconstituting your peptide, measure the desired amount out for injection. Use a U100 insulin syringe to draw out and inject your product.

Since you know the amount of IU's/MG's in your vial, we divide this out as follows:
You will need to know the following to be successful: 1ml = 1cc = 100 IU's

We take our dose from the label of the dry lyophilized powder and we divide that into the amount of diluent used.

Example- We used 1cc(ml) of water. We have a 10 IU vial of HGH.
From our formula above we know that 1cc = 100 IU's, so we have 100 IU's of water.
We now divide the 100 IU's (the amount of our water) by 10 IU's (the amount of our HGH)
100 IU / 10 IU = 10

This 10 will perfectly correspond with the markings on a U100 insulin syringe. In our example every 10 mark on our syringe will equal 1 IU of HGH. Want to draw out 2 IU's of GH? ....draw out to the 20 mark on the syringe (1/5th of the syringe).
Say you have a 1mg vial and you add 1ML you get
1000mcg/1mL: 10 mcg per IU
1000mcg/2mL: 5 mcg per IU
Say you have a 10mg vial and you add 1ML you get
10mg/1mL: 1 mg per 10 IU
10mg/2mL: .5 mg per 10 IU
Say you have a 20mg vial and you add 1ML you get
20mg/1mL: 2 mg per 10 IU
20mg/2mL: 1 mg per 10 IU
Say you have a 10iu vial and you add 1ML you get
10iu/1mL: 1 iu per 10 IU (on the syringe - 1/10th the product)
10iu/2mL: 1 iu per 20 IU (on the syringe - still 1/10th the product)
Say you have a 5000iu vial and you add 1ML you get
5000iu/1mL: 500iu per 10 IU
5000iu/2mL: 250iu per 10 IU

 Melanotan  1


Afamelanotide (M-I) Dose:
Light: .5mg
Common: 1mg
Large: 2mg
Melanotan 1 synthetic melanocyte stimulating hormone (a-MSH) induces skin pigmentation through melanogenisis, melanin production. Melanin prevents cellular damage in the skin by absorbing, reflecting and refracting light. Melanotan reduces sun damage to UV exposed skin transforming cells to produce dark protective melanin.

Melanotan Results: Melanotan favors production of eumelanin (black/brown) over pheomelanin pigment. Injecting this linear amino acid Melanotan 1 peptide offers super-physiological levels of tanning ability.

 Melanotan 2


Melanotan 2 Dose:
Begin: 100mcg
Light: 250mcg
Common: 500mcg
Stout: 1mg
Large: 1.5mg
Max: 2mg
What is Melanotan 2
Melanotan II analog of alpha-melanocyte stimulating hormone (a-MSH). Melanotan peptides are safe and efficacious with growing long term data. Melanotan 2 is a freeze dried peptide sealed in a sterile multi-use vial. Generic 10mg Melanotan II:

Melanotan injections act on melanocytes to stimulate melanin production. Melanin is the body's pigment responsible for a photoprotective safe tan.

Bremelanotide


Bremelanotide PT 141 Dose:
Light: .5mg
Common: 1mg
Large: 2mg
Bremelanotide PT-141 was developed from Melanotan 2 (MT-II). PT-141 is a metabolite of melanocyte stimulating hormone that targets desire.

Treatment: PT-141 is the only synthetic aphrodisiac. The aphrodisiac effects of Bremelanotide are in a class of its own. Studies have shown Bremelanotide to be effective in treating sexual dysfunction in both men (erectile dysfunction or impotence) and women (sexual arousal disorder). Nine out of ten volunteers experienced sexual arousal in clinical trials. Unlike Viagra and other related medications (PDE5s - blood pushers), PT-141 acts upon the nervous system. Viagra, Cials and Levitra are not considered aphrodisiacs as they do not have any direct effect on the libido. However, treatment with PDE5 inhibitors and PT-141 have known synergy.

Men's Journal Magazine: ...it took hold. I felt a great surge of affection (greater than any regular level of arousal). My body tingled and I developed an erection that wouldn’t quit. For two hours the drug wouldn’t let me out of its grasp — nor my wife out of mine. -Frederick Kaufman

Females: Women who took part in trials said that they felt a "tingling and a throbbing" along with "a strong desire to have sex." An initial flush occurs post injection, followed by nausea which is dose dependent. For most, effects generally do not take place until a couple hours post injection, peaking around the four hour mark. Men said PT-141 made them feel "younger and more energetic" as well as sexually interested and aroused. "You're ready to take your pants off and go," said user "a product that makes you not only able to but eager to."
Bremelanotide PT-141 Peptide: Bremelanotide comes in 10mg vials. As a lifestyle peptide, the 10mg product is a lot to consume and may offer up to 20 doses when dosing conservatively. Research PT-141 reconstituted with bacteriostatic water remains potent in the fridge for months.
Window of Opportunity: Bremelanotide, injected (subcutaneously), has a unique window of opportunity lasting six to 72 hours. In lab trials female rats exposed to PT-141 began "flirting" with male rats for sex. Postures and movements left no doubt in the male rats minds that they were in the mood. The human PT-141 date is one where the dosage precedes the activity by at least a couple hours. When the stars align, hours after the injection, ...this is your window of opportunity, enjoy.
Mixing: Bacteriostatic water is used for reconstitution.
Example- 1ml(cc) bacteriostatic water per 10mg PT-141 vial equates to a 1mg dose approximately each 10 units on a U100 insulin syringe.
Example- 1ml(cc) bacteriostatic water per 2mg PT-141 vial equates to a 1mg dose approximately every 50 units on a U100 insulin syringe.
Recommended strategy for mixing and dosing would be to reconstitute with the volume that yields a .1ml injection.
Example- 1ml(cc) bacteriostatic water per 10mg PT-141 vial equates to a 1mg dose approximately each 10 units on a U100 insulin syringe.
Example- .2ml(cc) bacteriostatic water per 2mg PT-141 vial equates to a 1mg dose approximately every 10 units on a U100 insulin syringe.
Dosing: Read as much as possible to gain clarity and align expectations. Gradually dosing increases likelihood for success without sides. A test dose of .25-.5mg on the first attempt is recommended. 1mg, give or take a quarter, is the efficacious dose which yields the most positive reports by users.

Ghrp-6


GHRP-6 Hexapeptide Dosage:
Light: 50mcg
Common: 100mcg
Large: 150mcg
Growth Hormone Releasing Peptide (GHRP-6) is a peptide in the growth factor family. It has strong effect on the release of Human Growth Hormone (HGH) in a specific and dose-related manner. GHRP can be effectively used in the treatment of growth hormone (GH) deficiency. Growth hormone releasing hexapeptide works by signaling the pituitary gland to begin growth hormone secretion.

Increased GH and IGF-1 levels are desirable for those looking to improve physique. Human growth hormone has been known to enhance immune response and stimulate the immune system, particularly older subjects. Dosed at night for anti-aging purposes and multiple times throughout the day for anabolism. GHRP is often used in conjunction with GHRH CJC-1295 (mod GRF 1-29) to amplify growth hormone pulse. Avoid fats and carbohydrate a half hour on each side of dosing GHRP-6.

Bodybuilders and athletes dose GHRP in an effort to build more muscle and burn fat. Some GHRP-6 users include it in their post cycle therapy (PCT). Cycling GHRP-6 in the off weeks from IGF/GH cycles is also becoming prevalent. Researchers wish to kick-start their body into producing their own natural GH & IGF, while gaining as if they remained on the GH/IGF peptides.

GHRP-6's main use is to promote food intake by stimulating hunger and aid in energy metabolism. The major side effect being a significant increase in appetite due to a stimulating the release of Ghrelin (about 20 minutes post injection), a hormone released naturally in the lining of the stomach and increases hunger and gastric emptying. This is why GHRP-6 can be used in the treatment of cachexia (wasting), eating disorders and obesity.

Benefits of increased HGH levels through GHRP-6 stimulation include: an increase in strength, muscle mass and body fat loss, rejuvenation and strengthening of joints, connective tissue and bone mass. Enhanced HGH secretion also leads to the liver secreting more IGF-1, which is thought to be the primary anabolic mechanism of action for Growth Hormone.
Bodybuilding Peptide GHRP-6:

Mixing: Bacteriostatic water is used for reconstitution. When diluted, peptide lasts a very long time when left alone in the refrigerator (months)

Example- 2.5ml(cc) bacteriostatic water per 5mg GHRP vial equates to a 100mcg dose approximately each 2-3 marks on a U100 insulin syringe.
Example- 5ml(cc) bacteriostatic water per 5mg GHRP vial equates to a 100mcg dose approximately every 5 marks on a U100 insulin syringe.

Dosing: The saturation dose of GHRP-6 has been determined to be around 100mcg. More is not better in regards to this secretagogue

5mg GHRP = 5,000mcg

5,000mcg/100mcg = 50 100mcg GHRP doses per 5mg

Growth Hormone Releasing Hormone (CJC-1295)



Modified GRF 1-29 (GHRH) CJC1295 Dosage:
Light: 25mcg
Common: 50mcg
Large: 100mcg
Growth Hormone Releasing Hormone (GHRH) CJC-1295 is a synthetic secretagogue which stimulates HGH release. In the human body, large amounts of growth hormone are stored in the pituitary. GHRH affects the number of secreting cells and the amount they are able to secrete. GHRH Analog research peptides sold online are a fantastic addition to GHRP (GHRP-6 & GHRP-2).

Dosing GHRH once at night for anti-aging purposes and multiple injections (1-3x) for anabolism. CJC-1295 has the ability to make the body produce its own GH as compared to using synthetic HGH. GHRP-6 use in conjunction with CJC-1295 is synergistic, amplifying the GH pulse considerably. Synthetic GH side effects can be experienced with pure growth factor peptides. Researchers also report positive effects much like that of HGH. Particularly energy, quality sleep, fat loss/metabolism, improved skin quality, pumps in the gym and numb/tingles at extremities.

CJC-1295 is typically found in 2mg vials. Reconstitute with BW. Inject subcutaneously. Generally best to invest in shorter acting modified GRF 1-29 as CJC-1295 manufacturing is difficult and fragile. GHRH (mod GRF 1-29) dose has 30 minute half life, superior to that of Sermorelin. Post injection flush is common. Ipamorelin is increasingly popular research peptide alternative. Genuine CJC-1295 DAC bloats male researchers, best to avoid real CJC-1295.



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CJC-1295 Growth Hormone Releasing Hormone

CJC-1295 Growth Hormone Releasing Hormone

 
Modified GRF 1-29 CJC-1295 Dosage (GHRH):
Light: 25mcg
 Common: 50mcg
 Large: 100mcg

Growth Hormone Releasing Hormone CJC-1295 is a synthetic secretagogue which stimulates HGH release. In the human body, large amounts of growth hormone are stored in the pituitary. GHRH affects the number of secreting cells and the amount they are able to secrete. GHRH Analog research peptides sold online are a fantastic addition to GHRP (GHRP-6 & GHRP-2).

 Dosing CJC-1295 GHRH protocols range from once at night for anti-aging purposes and multiple injections (1-3x) for anabolism effects. CJC-1295 has the ability to make the body produce its own GH as compared to using synthetic HGH. GHRP-6 use in conjunction with CJC-1295 is synergistic, amplifying the GH pulse considerably. Synthetic GH side effects can be experienced with pure growth factor peptides. Researchers also report positive effects much like that of HGH. Particularly energy, quality sleep, fat loss/metabolism, improved skin quality, pumps in the gym and numb/tingles at extremities.

CJC-1295 is typically found in 2mg vials. Reconstitute with BW. Inject subcutaneously. Generally best to invest in shorter acting modified GRF 1-29 as CJC-1295 manufacturing is difficult and fragile. GHRH (mod GRF 1-29) dose has 30 minute half life, superior to that of Sermorelin. Post injection flush is common. Ipamorelin is increasingly popular research peptide alternative. Genuine CJC-1295 DAC bloats male researchers, best to avoid real CJC-1295.

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Growth Hormone Releasing Peptides and Hormones GHRP - GHRH

Growth Hormone Releasing Peptides and Hormones GHRP - GHRH

Growth Hormone (GH) Questions


What is growth hormone?

Synthetic Growth Hormone (Somatropin) is an artificially created hormone (made up of a sequence of 191 amino acids) that is identical to the one found in humans. Some common names of synthetic growth hormone include: Genotropin by Genentech, Humatrope by Eli Lilly, Nutropin by Genentech and Saizen by Serono. While many companies are capable of generating growth hormone not all of the companies are capable of creating the correct structure that is identical to naturally occurring growth hormone. The structure determines the strength with which the growth hormone molecule binds to a receptor which will in turn affect the "strength" of the events leading to protein transcription, metabolism, IGF-1 creation, etc. It is this inconsistency that accounts in part for the differences in effectiveness of various produced synthetic growth hormone. Synthetic growth hormone is not really true or natural growth hormone. It was manufactured in a laboratory and not by your pituitary.


Naturally produced Growth Hormone is produced in the anterior pituitary. It is made up of a blend of amino acids with the majority of them being the 191 amino acid variety.

How does growth hormone work?

Growth hormone in the body is released in a pulsating fashion. It has been demonstrated that this pattern promotes growth. The pituitary is capable of rather quickly synthesizing very large amounts of growth hormone which it stores in both a finished and unfinished form. Adults rarely experience growth hormone pulses that completely deplete these stores. As we get older we do not lose the ability to create and store large amounts of growth hormone, rather we experience a diminished capacity to instruct their release. The growth hormone pulse is measured in a wave with the trough being the “off” or non-secretion of growth hormone and the crest being the “on” or highest point during growth hormone secretion.

The volume of growth hormone that is released in the body cannot be properly compared to the administration of synthetic growth hormone for the reason that a set of behavioral characteristics associated with natural growth hormone differ from those of synthetic growth hormone. Therefore attempting to find a natural growth hormone to a synthetic growth hormone equivalency is not very productive because in the end what is probably most important is: The quantity and quality of intracellular signaling events and the degree to which growth hormone stimulates autocrine/paracrine (locally produced/locally used) muscle IGF-1 & post-exercise its splice variant MGF
.

How is natural growth hormone released?

Growth hormone release in the pituitary depends on 3 factors:
  1. Somatostatin which is the inhibitory hormone and responsible in large part for the creation of pulsation.
  2. Growth Hormone Releasing Hormone (GHRH) which is the stimulatory hormone responsible for initiating growth hormone release.
  3. Growth Hormone Releasing Peptides (GHRP) which is a modulating hormone and in essence optimizes the balance between the "on" and the "off" periods of growth hormone.

Naturally produced Growth Hormone


What types of Growth Hormone Releasing Hormone (GHRH) are there?

  • GRF(1-44) with a  half-life is less than 5-10 minutes
  • GRF(1-29) Sermorelin with a half-life is less than 5-10 minutes
  • Modified GRF(1-29) or CJC-1295 without DAC with a Half-life at least 30 minutes
  • CJC-1295 (with DAC) with a Half-life measured in days
Growth Hormone Releasing Hormone (GHRH) pulses can only last less than 30 minutes before your body has used out the potential for a single growth hormone pulse. Since another pulse won't be generated for about 2.5 - 3 hours hormones that last more than 30 minutes up to 3 hours are not any more beneficial.

The administration of Growth Hormone Releasing Hormone (GHRH) creates a pulse of growth hormone release which will be small if administered during a natural growth hormone trough and higher if administered during a rising natural growth hormone wave.

How much Growth Hormone Releasing Hormone (GHRH) should be used?

The saturation dose in most studies is defined as 100mcg or 1mcg/kg per growth hormone pulse.

How long should Growth Hormone Releasing Hormone (GHRH) be used?

In most studies no adverse side effects were reported with continued use.

Which Growth Hormone Releasing Hormone (GHRH) is the best to use? Modified GRF(1-29) or CJC-1295 without DAC is the best choice because it lasts at least 30 minutes. Growth Hormone pulses can only last less than 30 minutes before your body has used out the potential for a single growth hormone pulse.

What types of Growth Hormone Releasing Peptides are there?

Growth Hormone Releasing Peptides (GHRP) (Growth hormone pulse initiators):
  • Ipamorelin is potent but the weakest growth hormone releaser. It does not increase cortisol or prolactin at any dose.
  • GHRP-6 is very potent in effecting growth hormone release. It does not effect cortisol or prolactin up to a 100mcg dose, but does so minimally above 100mcg
  • GHRP-2 is a little bit more potent then GHRP-6. It also has a stronger effect on these hormones at all dosing levels rising to the high normal range for cortisol and prolactin.
  • Hexarelin the strongest is a little more potent then GHRP-2. At all dosing levels it has the strongest impact on cortisol and prolactin with levels in the upper bounds of normalcy.

Growth Hormone Releasing Peptides (GHRP) can become desensitized with constant usage throughout the day. Ipamorelin and GHRP-6 do not desensitize as long as there are short breaks between doses minimal 2 hours. GHRP-2 does not desensitize in the lower dose ranges without short breaks. At high dose it is unclear, but some desensitization may occur. Hexarelin has been shown to desensitize without regard to dose and even with short breaks between doses. This effect shows up after 14 days of continuous use and may be avoided by either keeping doses low or taking a full day or two off every two weeks.
Growth Hormone Releasing Peptides (GHRP) are capable of creating a larger pulse of growth hormone on their own than Growth Hormone Releasing Hormone (GHRH) and they do this with much more consistency and predictability without regard to whether a natural wave or trough of growth hormone is currently taking place.

How much Growth Hormone Releasing Peptides (GHRP) should be used?
The saturation dose in most studies on Growth Hormone Releasing Peptides (GHRP) is defined as either 100mcg or 1mcg/kg.

This means that 100mcg will saturate the receptors fully, but if you add another 100mcg to that dose only 50% of that portion will be effective. If you add an additional 100mcg to that dose only about 25% will be effective. Perhaps a final 100mcg might add a little something to growth hormone release but that is it.

If 100mcg is the saturation dose, you could add more (up to 300-400mcg) and get a little more effect. A 500mcg dose will not be more effective than a 400mcg, perhaps not even more effective than 300mcg.

The additional problems with higher dosages are desensitization and cortisol/prolactin side-effects.

Ipamorelin and GHRP-6 at the saturation dose of 100mcg does not really increase prolactin & cortisol but may do so slightly at higher doses. This rise is still within the normal range. It can be used at saturation dose (100mcg) three or four times a day without risk of desensitization.

GHRP-2 is more effective then GHRP-6 at causing growth hormone release but at the saturation dose of a 100mcg or higher may produce a slight to moderate increase in prolactin & cortisol. This rise is still within the normal range although doses of 200 - 400mcg might make it the high end of the normal range. It can be used at saturation dose several times a day will not result in desensitization.

Hexarelin in general is the most effective at causing an increase in growth hormone release. However it has the highest potential to also increase cortisol & prolactin. This rise will occur even at the 100mcg saturation dose. This rise will reach the higher levels of what is defined as normal. It has been shown to bring about desensitization but in a long-term study the pituitary recovered its sensitivity so that there was not long-term loss of sensitivity at saturation dose. Even at 100mcg three times a day will likely lead to some down regulation within 14 days.

If desensitization were to ever occur for any of these Growth Hormone Releasing Peptides (GHRP) simply stop administering them for several days and this will remedy the effect.

How long should Growth Hormone Releasing Peptides (GHRP) be used?

In most studies no adverse side effects were reported with continued use.

Which Growth Hormone Releasing Peptides (GHRP) is the best to use?

It depends on what results you are looking for:
  • Ipamorelin is good for fatloss and injury repair
  • GHRP-6 is good for gaining weight/bulking since it increases appetite.
  • GHRP-2 is good for muscle gain, fatloss and injury repair (some people have increased appetite).

Does Growth Hormone Releasing Hormone (GHRH) and Growth Hormone Releasing Peptides (GHRP) work together better?

It is well documented and established that the concurrent administration of Growth Hormone Releasing Hormone (GHRH) and Growth Hormone Releasing Peptides (GHRP) results in synergistic release of growth hormone from pituitary.

In other words if Growth Hormone Releasing Hormone (GHRH) contributes a growth hormone amount quantified as the number 2 and Growth Hormone Releasing Peptides (GHRP) contributed a growth hormone amount quantified as the number 4 the total growth hormone release is not additive (i.e. 2 + 4 = 6). Rather the whole is greater than the sum of the parts such that 2 + 4 = 12.

Can Growth Hormone Releasing Hormone (GHRH) be used alone?
The problem with using only Growth Hormone Releasing Hormone (GHRH) (even the stronger analogs) is that they are only effective when somatostatin is low (the growth hormone inhibiting hormone). So if you administer it in a trough (or when a growth hormone pulse is not naturally occurring) you will add very little growth hormone release. If however you administer it during a rising wave or growth hormone pulse (somatostatin will not be active at this point) you will add to growth hormone release.

Can Growth Hormone Releasing Peptides (GHRP) be used alone? Yes. They are capable of creating a larger pulse of growth hormone on their own than Growth Hormone Releasing Hormone (GHRH) and they do this with much more consistency and predictability without regard to whether a natural wave or trough of growth hormone is currently taking place.

What is a typical protocol for Growth Hormone Releasing Hormone (GHRH) and Growth Hormone Releasing Peptides (GHRP)?

A typical beginner protocol would be:
  • 50-100mcg of Growth Hormone Releasing Peptides (GHRP) plus
  • 50-100mcg of Growth Hormone Releasing Hormone (GHRH). 
2-3 days on 1 day off then repeat - before bed - subcutaneous injections

A typical intermediate protocol would be:
  • 100-200mcg of Growth Hormone Releasing Peptides (GHRP) plus 100-200mcg of Growth Hormone Releasing Hormone (GHRH).
3-4 days on 1 day off then repeat - before bed - subcutaneous injections

A typical advance protocol would be:
  •  100-200mcg of Growth Hormone Releasing Peptides (GHRP) plus
  • 100-200mcg of Growth Hormone Releasing Hormone (GHRH).
2 times daily - before breakfast and bed - subcutaneous injections
These protocols can be used once, twice, three or four times a day to make it more effective. When dosing multiple times a day at least 3 hours should separate the administrations.

Once a day dosing pre-bed will give a restorative/injury repair amount of growth hormone while multiple dosing and/or higher levels will give higher growth hormone & IGF-1 levels which will lead to muscle gain, fatloss and/or injury repair.

What are some of the possible side effects with Growth Hormone Releasing Hormone (GHRH) and/or Growth Hormone Releasing Peptides (GHRP)?

Reported side effects have included: hypersomnia (excessive sleeping), insomnia, muscle soreness (from muscle growth), burning feeling at injection spot (last 10-15 minutes). All side effects went away after 2-3days of discontinuing use.

Should food be consumed before or after the injection of Growth Hormone Releasing Hormone (GHRH) and/or Growth Hormone Releasing Peptides (GHRP)?

Administration should ideally be done on either an empty stomach or with only protein in the stomach. Fats and carbohydrates blunt growth hormone release. After administering the peptides wait at least 30 minutes to eat. At that point the growth hormone pulse has reached its peak and you can eat what you want


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CJC-1295 / GHRP-6 reconstitution and dosing schedule

This seems to be the most effective dosing schedule. This cycle has done the best for most people running CJC-1295 + GHRP-6 You can substitute GHRP-2  for the GHRP-6

100mcg of CJC-1295 + 100-200 mcg GHRP-6 three times a day.
in the morning on an empty stomach 25 minutes before eating
in the afternoon - PWO
finally just before bed

5mg ghrp-6 vial reconstitute with 2.5mls of bac water = 2000mcgs per ml = each 10mark on the slin pin = 200mcgs
2mg CJC-1295 vial reconstitute with 2mls of bac water = 2000mcgs per ml = each 10mark on the slin pin = 100mcgs
+
Get your bacteriostatic water here                                   Get your CJC-1295 + GHRP-6 Here

From basskiller

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Growth Hormone Releasing Hormone (GHRH)/CJC-1295

It increases protein synthesis and stimulates the growth of new muscle tissue.

- Allows for normal growth in short children with GH deficiency.
- Increases muscle mass (and physical strength if combined with moderate exercise).
- Reduces wrinkling of the skin and some other effects of skin aging.
- Re-grows internal organs that have atrophied with age.
- Causes hyperplasia, the increase of more muscle cells.
- It increases muscle mass through the creation of new muscle cells (which differs from hypertrophy).
- It promotes lipolysis, which results in the reduction of adipose tissue (body fat).
- Increased bone density.
- Faster recovery from exercise, exertion, and injuries.
- Strengthen the immune system.

It is important to begin the discussion of CJC-1295 with a discussion of the parent of the Growth Hormone Releasing Factors which is somatocrinin., this peptide ultimately gave birth to the newer generations of Growth-hormone-releasing hormone peptides (CJC-1295).

Growth-hormone-releasing hormone (GHRH), also known as growth-hormone-releasing factor (GRF or GHRF) or somatocrinin, is a 44-amino acid peptide hormone produced in the arcuate nucleus of the hypothalamus. GHRH is released from neurosecretory nerve terminals of these arcuate neurons, and is carried by the hypothalamo-hypophysial portal circulation to the anterior pituitary gland where it stimulates growth hormone secretion. GHRH stimulates the production of growth hormone.

GHRH gave birth to a more compact growth hormone releasing factor known as Sermorelin which is a synthetic analogue of growth hormone releasing hormone, which is produced by the hypothalamus. Sermorelin acetate is the acetate salt of an amidated synthetic 29-amino acid peptide that corresponds to the amino-terminal segment of the naturally occurring human growth hormone-releasing hormone (GHRH or GRF) consisting of 44 amino acid residues.

The free base of sermorelin has the empirical formula C 149 H 246 N 44 O 42 S and a molecular weight of 3,358 daltons. Sermorelin stimulates ..........
Growth Hormone Releasing Hormone (GHRH)/CJC-1295


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