Growth Hormone Releasing Peptides and Hormones GHRP - GHRH

Growth Hormone Releasing Peptides and Hormones GHRP - GHRH

Growth Hormone (GH) Questions

What is growth hormone?

Synthetic Growth Hormone (Somatropin) is an artificially created hormone (made up of a sequence of 191 amino acids) that is identical to the one found in humans. Some common names of synthetic growth hormone include: Genotropin by Genentech, Humatrope by Eli Lilly, Nutropin by Genentech and Saizen by Serono. While many companies are capable of generating growth hormone not all of the companies are capable of creating the correct structure that is identical to naturally occurring growth hormone. The structure determines the strength with which the growth hormone molecule binds to a receptor which will in turn affect the "strength" of the events leading to protein transcription, metabolism, IGF-1 creation, etc. It is this inconsistency that accounts in part for the differences in effectiveness of various produced synthetic growth hormone. Synthetic growth hormone is not really true or natural growth hormone. It was manufactured in a laboratory and not by your pituitary.


Naturally produced Growth Hormone is produced in the anterior pituitary. It is made up of a blend of amino acids with the majority of them being the 191 amino acid variety.

How does growth hormone work?

Growth hormone in the body is released in a pulsating fashion. It has been demonstrated that this pattern promotes growth. The pituitary is capable of rather quickly synthesizing very large amounts of growth hormone which it stores in both a finished and unfinished form. Adults rarely experience growth hormone pulses that completely deplete these stores. As we get older we do not lose the ability to create and store large amounts of growth hormone, rather we experience a diminished capacity to instruct their release. The growth hormone pulse is measured in a wave with the trough being the “off” or non-secretion of growth hormone and the crest being the “on” or highest point during growth hormone secretion.

The volume of growth hormone that is released in the body cannot be properly compared to the administration of synthetic growth hormone for the reason that a set of behavioral characteristics associated with natural growth hormone differ from those of synthetic growth hormone. Therefore attempting to find a natural growth hormone to a synthetic growth hormone equivalency is not very productive because in the end what is probably most important is: The quantity and quality of intracellular signaling events and the degree to which growth hormone stimulates autocrine/paracrine (locally produced/locally used) muscle IGF-1 & post-exercise its splice variant MGF
.

How is natural growth hormone released?

Growth hormone release in the pituitary depends on 3 factors:

1. Somatostatin which is the inhibitory hormone and responsible in large part for the creation of pulsation.
2. Growth Hormone Releasing Hormone (GHRH) which is the stimulatory hormone responsible for initiating growth hormone release.
3. Growth Hormone Releasing Peptides (GHRP) which is a modulating hormone and in essence optimizes the balance between the "on" and the "off" periods of growth hormone.

Naturally produced Growth Hormone

What types of Growth Hormone Releasing Hormone (GHRH) are there?

• GRF(1-44) with a  half-life is less than 5-10 minutes
• GRF(1-29) Sermorelin with a half-life is less than 5-10 minutes
• Modified GRF(1-29) or CJC-1295 without DAC with a Half-life at least 30 minutes
• CJC-1295 (with DAC) with a Half-life measured in days

Growth Hormone Releasing Hormone (GHRH) pulses can only last less than 30 minutes before your body has used out the potential for a single growth hormone pulse. Since another pulse won't be generated for about 2.5 - 3 hours hormones that last more than 30 minutes up to 3 hours are not any more beneficial.

The administration of Growth Hormone Releasing Hormone (GHRH) creates a pulse of growth hormone release which will be small if administered during a natural growth hormone trough and higher if administered during a rising natural growth hormone wave.

How much Growth Hormone Releasing Hormone (GHRH) should be used?

The saturation dose in most studies is defined as 100mcg or 1mcg/kg per growth hormone pulse.

How long should Growth Hormone Releasing Hormone (GHRH) be used?

In most studies no adverse side effects were reported with continued use.

Which Growth Hormone Releasing Hormone (GHRH) is the best to use? Modified GRF(1-29) or CJC-1295 without DAC is the best choice because it lasts at least 30 minutes. Growth Hormone pulses can only last less than 30 minutes before your body has used out the potential for a single growth hormone pulse.

What types of Growth Hormone Releasing Peptides are there?

Growth Hormone Releasing Peptides (GHRP) (Growth hormone pulse initiators):

• Ipamorelin is potent but the weakest growth hormone releaser. It does not increase cortisol or prolactin at any dose.
• GHRP-6 is very potent in effecting growth hormone release. It does not effect cortisol or prolactin up to a 100mcg dose, but does so minimally above 100mcg
• GHRP-2 is a little bit more potent then GHRP-6. It also has a stronger effect on these hormones at all dosing levels rising to the high normal range for cortisol and prolactin.
• Hexarelin the strongest is a little more potent then GHRP-2. At all dosing levels it has the strongest impact on cortisol and prolactin with levels in the upper bounds of normalcy.

Growth Hormone Releasing Peptides (GHRP) can become desensitized with constant usage throughout the day. Ipamorelin and GHRP-6 do not desensitize as long as there are short breaks between doses minimal 2 hours. GHRP-2 does not desensitize in the lower dose ranges without short breaks. At high dose it is unclear, but some desensitization may occur. Hexarelin has been shown to desensitize without regard to dose and even with short breaks between doses. This effect shows up after 14 days of continuous use and may be avoided by either keeping doses low or taking a full day or two off every two weeks.
Growth Hormone Releasing Peptides (GHRP) are capable of creating a larger pulse of growth hormone on their own than Growth Hormone Releasing Hormone (GHRH) and they do this with much more consistency and predictability without regard to whether a natural wave or trough of growth hormone is currently taking place.

How much Growth Hormone Releasing Peptides (GHRP) should be used?
The saturation dose in most studies on Growth Hormone Releasing Peptides (GHRP) is defined as either 100mcg or 1mcg/kg.

This means that 100mcg will saturate the receptors fully, but if you add another 100mcg to that dose only 50% of that portion will be effective. If you add an additional 100mcg to that dose only about 25% will be effective. Perhaps a final 100mcg might add a little something to growth hormone release but that is it.

If 100mcg is the saturation dose, you could add more (up to 300-400mcg) and get a little more effect. A 500mcg dose will not be more effective than a 400mcg, perhaps not even more effective than 300mcg.

The additional problems with higher dosages are desensitization and cortisol/prolactin side-effects.

Ipamorelin and GHRP-6 at the saturation dose of 100mcg does not really increase prolactin & cortisol but may do so slightly at higher doses. This rise is still within the normal range. It can be used at saturation dose (100mcg) three or four times a day without risk of desensitization.

GHRP-2 is more effective then GHRP-6 at causing growth hormone release but at the saturation dose of a 100mcg or higher may produce a slight to moderate increase in prolactin & cortisol. This rise is still within the normal range although doses of 200 - 400mcg might make it the high end of the normal range. It can be used at saturation dose several times a day will not result in desensitization.

Hexarelin in general is the most effective at causing an increase in growth hormone release. However it has the highest potential to also increase cortisol & prolactin. This rise will occur even at the 100mcg saturation dose. This rise will reach the higher levels of what is defined as normal. It has been shown to bring about desensitization but in a long-term study the pituitary recovered its sensitivity so that there was not long-term loss of sensitivity at saturation dose. Even at 100mcg three times a day will likely lead to some down regulation within 14 days.

If desensitization were to ever occur for any of these Growth Hormone Releasing Peptides (GHRP) simply stop administering them for several days and this will remedy the effect.

How long should Growth Hormone Releasing Peptides (GHRP) be used?

In most studies no adverse side effects were reported with continued use.

Which Growth Hormone Releasing Peptides (GHRP) is the best to use?

It depends on what results you are looking for:

• Ipamorelin is good for fatloss and injury repair
• GHRP-6 is good for gaining weight/bulking since it increases appetite.
• GHRP-2 is good for muscle gain, fatloss and injury repair (some people have increased appetite).

Does Growth Hormone Releasing Hormone (GHRH) and Growth Hormone Releasing Peptides (GHRP) work together better?

It is well documented and established that the concurrent administration of Growth Hormone Releasing Hormone (GHRH) and Growth Hormone Releasing Peptides (GHRP) results in synergistic release of growth hormone from pituitary.

In other words if Growth Hormone Releasing Hormone (GHRH) contributes a growth hormone amount quantified as the number 2 and Growth Hormone Releasing Peptides (GHRP) contributed a growth hormone amount quantified as the number 4 the total growth hormone release is not additive (i.e. 2 + 4 = 6). Rather the whole is greater than the sum of the parts such that 2 + 4 = 12.

Can Growth Hormone Releasing Hormone (GHRH) be used alone?
The problem with using only Growth Hormone Releasing Hormone (GHRH) (even the stronger analogs) is that they are only effective when somatostatin is low (the growth hormone inhibiting hormone). So if you administer it in a trough (or when a growth hormone pulse is not naturally occurring) you will add very little growth hormone release. If however you administer it during a rising wave or growth hormone pulse (somatostatin will not be active at this point) you will add to growth hormone release.

Can Growth Hormone Releasing Peptides (GHRP) be used alone? Yes. They are capable of creating a larger pulse of growth hormone on their own than Growth Hormone Releasing Hormone (GHRH) and they do this with much more consistency and predictability without regard to whether a natural wave or trough of growth hormone is currently taking place.

What is a typical protocol for Growth Hormone Releasing Hormone (GHRH) and Growth Hormone Releasing Peptides (GHRP)?

A typical beginner protocol would be:

• 50-100mcg of Growth Hormone Releasing Peptides (GHRP) plus
• 50-100mcg of Growth Hormone Releasing Hormone (GHRH). 

2-3 days on 1 day off then repeat - before bed - subcutaneous injections

A typical intermediate protocol would be:

• 100-200mcg of Growth Hormone Releasing Peptides (GHRP) plus 100-200mcg of Growth Hormone Releasing Hormone (GHRH).

3-4 days on 1 day off then repeat - before bed - subcutaneous injections

A typical advance protocol would be:

•  100-200mcg of Growth Hormone Releasing Peptides (GHRP) plus
• 100-200mcg of Growth Hormone Releasing Hormone (GHRH).

2 times daily - before breakfast and bed - subcutaneous injections
These protocols can be used once, twice, three or four times a day to make it more effective. When dosing multiple times a day at least 3 hours should separate the administrations.

Once a day dosing pre-bed will give a restorative/injury repair amount of growth hormone while multiple dosing and/or higher levels will give higher growth hormone & IGF-1 levels which will lead to muscle gain, fatloss and/or injury repair.

What are some of the possible side effects with Growth Hormone Releasing Hormone (GHRH) and/or Growth Hormone Releasing Peptides (GHRP)?

Reported side effects have included: hypersomnia (excessive sleeping), insomnia, muscle soreness (from muscle growth), burning feeling at injection spot (last 10-15 minutes). All side effects went away after 2-3days of discontinuing use.

Should food be consumed before or after the injection of Growth Hormone Releasing Hormone (GHRH) and/or Growth Hormone Releasing Peptides (GHRP)?

Administration should ideally be done on either an empty stomach or with only protein in the stomach. Fats and carbohydrates blunt growth hormone release. After administering the peptides wait at least 30 minutes to eat. At that point the growth hormone pulse has reached its peak and you can eat what you want

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IGF-1 Peptides

What is IGF-1?
IGF-1 is a polypeptide hormone about the same size as insulin, or 70 amino acids. It´s a highly anabolic hormone released primarily in the liver (but also in peripheral tissues) and stimulates the production of growth hormone. It is responsible for much of the anabolic activity of growth hormone, including nitrogen retention and protein synthesis as well as muscle cell hyperplasia (increase in number of muscle cells), as well as mitogenesis (the growth of new muscle fibers).

IGF-1 is necessary as well as sufficient in muscle growth (anabolic) and has been shown to also be highly anti-catabolic agent as well. As with all anabolic substances, IGF-1´s anabolic effects are still limited only by the protein supply within muscle cells. Thus IGF works much better when enough protein is supplied to the muscle.

For athletes and bodybuilders who are rehabilitating an injury IGF is vital to the proper production of connective tissue, and studies have shown that exogenous IGF administration may improve collagen formation and aid in the repair of cartilage and would greatly decrease recovery time as well as increase the strength of the recovered area.

A study examined the injection of insulin-like growth factor I (IGF-I) in different muscle fibers. The researchers concluded that IGF-I promotes an average increase of 15% in muscle mass and a 14% increase in strength in muscle tissue. The researchers have speculated that these effects are primarily due to stimulation of muscle regeneration via the activation of satellite cells by IGF-I. 

A 15% increase in muscle mass, and a 14% increase in strength are no small increases. If we could realistically expect 7% gains in muscle mass and strength (half of the gains experienced in the study), then this would be able to help through plateaus or injuries.

What is IGF-1 Lr3?
IGF-1 Lr3 (Insulin-like Growth Factor-I Long R3) is an 83 amino acid analog of human IGF-I comprising the complete human IGF-I sequence with the substitution of an Arg for the Glu at position 3 (hence R3), as well as a 13 amino acid extension peptide at the N-terminus.  IGF-I Lr3 is significantly more potent (2-3x) than IGF-I in studies, because it has a lower affinity to be rendered inactive by IGF binding proteins.

What is a typical injection protocol for IGF-1 Lr3?

A typical protocol would be:
100-300mcg of IGF-1 Lr3 divided into 1-2 bilateral administrations in 2-5 different areas of the muscles approximately 5-7 days a week - intramuscular injections.

Example, if you want to administer 200mcg of IGF-1 Lr3 into the chest and biceps muscles 2 times a day and 3 different areas of the muscle then you would need to divided the dose as follows:

200mcg / 2 times per day = 100mcg per administration
100mcg per administration / 4 muscles (2 chest and 2 bicep muscles) = 25mcg per muscle
25mcg per muscle / 3 different locations on each muscle = 8.3mcg per injection

Theoretically, the more locations used to administer the IGF-1 Lr3 into the muscle the more places for muscle growth.

Studies have also suggested the following:
Administration should not be given within 2 hours after training in order not to reduce natural IGF-1 production.

Administration should not be given within 2 hours before sleeping in order not to reduce natural growth hormone production.

After administering, adequate protein needs to be ingested for IGF-1 to be effective in building new muscle.

How long should IGF-1 Lr3 be used?
In most studies on IGF-1 Lr3 no adverse side effects were reported with use for 4-8 weeks (per the dosage limits in the above answer) followed by 4 weeks of non-use

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Human Growth Hormone (HGH) Peptides

Human Growth Hormone (HGH) Peptides

Growth Hormone (GH) Questions

• What is growth hormone?
• How does growth hormone work?
• How is natural growth hormone released?

Synthetic Growth Hormone

• What is Human Growth Hormone (HGH) Fragment 176-191?
• How much Human Growth Hormone (HGH) Fragment 176-191 should be used?
• How long should Human Growth Hormone (HGH) Fragment 176-191 be used?
• What is a typical protocol for Human Growth Hormone (HGH) Fragment 176-191?
• What are some of the possible side effects with Human Growth Hormone (HGH) Fragment 176-191?
• Should food be consumed before or after the injection of Human Growth Hormone (HGH) Fragment 176-191?

 

Growth Hormone (GH) Questions

 What is growth hormone?
Synthetic Growth Hormone (Somatropin) is an artificially created hormone (made up of a sequence of 191 amino acids) that is identical to the one found in humans. Some common names of synthetic growth hormone include: Genotropin by Genentech, Humatrope by Eli Lilly, Nutropin by Genentech and Saizen by Serono. While many companies are capable of generating growth hormone not all of the companies are capable of creating the correct structure that is identical to naturally occurring growth hormone. The structure determines the strength with which the growth hormone molecule binds to a receptor which will in turn affect the "strength" of the events leading to protein transcription, metabolism, IGF-1 creation, etc. It is this inconsistency that accounts in part for the differences in effectiveness of various produced synthetic growth hormone. Synthetic growth hormone is not really true or natural growth hormone. It was manufactured in a laboratory and not by your pituitary.

Naturally produced Growth Hormone is produced in the anterior pituitary. It is made up of a blend of amino acids with the majority of them being the 191 amino acid variety.

How does growth hormone work?
Growth hormone in the body is released in a pulsating fashion. It has been demonstrated that this pattern promotes growth. The pituitary is capable of rather quickly synthesizing very large amounts of growth hormone which it stores in both a finished and unfinished form. Adults rarely experience growth hormone pulses that completely deplete these stores. As we get older we do not lose the ability to create and store large amounts of growth hormone, rather we experience a diminished capacity to instruct their release. The growth hormone pulse is measured in a wave with the trough being the “off” or non-secretion of growth hormone and the crest being the “on” or highest point during growth hormone secretion.

The volume of growth hormone that is released in the body cannot be properly compared to the administration of synthetic growth hormone for the reason that a set of behavioral characteristics associated with natural growth hormone differ from those of synthetic growth hormone. Therefore attempting to find a natural growth hormone to a synthetic growth hormone equivalency is not very productive because in the end what is probably most important is: The quantity and quality of intracellular signaling events and the degree to which growth hormone stimulates autocrine/paracrine (locally produced/locally used) muscle IGF-1 & post-exercise its splice variant MGF.

What is Human Growth Hormone (HGH) Fragment 176-191?
The HGH Fragment is a modified form of amino acids 176-191 at the C-terminal region of the human growth hormone (HGH). Studies have shown that it works by mimicking the way natural HGH regulates fat metabolism but without the adverse effects on insulin sensitivity (blood sugar) or cell proliferation (muscle growth) that is seen with unmodified HGH. Like unmodified GH, the HGH fragment 176-191 stimulates lipolysis (breaking down of fat) and inhibits lipogenesis (the formation of fatty acids and other lipids in the body).

HGH fragment 176-191 is meant to be 12.5 times stronger than human growth hormone (HGH) for weight loss than standard human growth hormone (HGH).

Of particular note is that in studies HGH fragment 176-191 had the ability to increase IGF-1 levels which translates into the fragments ability to give anti-aging effects.
 
How much Human Growth Hormone (HGH) Fragment 176-191 should be used?In most studies favorable results have been shown with dosages between 400-600mcg or 4-6mcg/kg split into multiple dosages per day.

How long should Human Growth Hormone (HGH) Fragment 176-191 be used?
In most studies no adverse side effects were reported with continuous use per the dosage limits in the above answer.

What is a typical protocol for Human Growth Hormone (HGH) Fragment 176-191?Studies have suggested the following:
A typical beginner protocol would be:
200mcg before breakfast
200mcg 30 minutes prior to training
Approximately 5-7 days a week - subcutaneous injections

A typical intermediate protocol would be:
250mcg before breakfast
250mcg 30 minutes prior to training
Approximately 5-7 days a week - subcutaneous injections

A typical advance protocol would be:
200mcg before breakfast
200mcg before lunch
200mcg 30 minutes prior to training
7 days a week - subcutaneous injections

When dosing multiple times a day at least 3 hours should separate the administrations.

What are some of the possible side effects with Human Growth Hormone (HGH) Fragment 176-191?Reported side effects have included: hypersomnia (excessive sleeping), insomnia, burning feeling at injection spot (last 10-15 minutes). All side effects went away after 2-3 days of discontinuing use.

 Should food be consumed before or after the injection of Human Growth Hormone (HGH) Fragment 176-191?Studies have shown that administration should ideally be done on either an empty stomach or with only protein in the stomach. Fats and carbohydrates blunt growth hormone release. After administering the peptides wait at least 30 minutes to eat. At that point the growth hormone pulse has reached its peak and you can eat what you want.

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MGF and PEG MGF  complete guide

WHAT IS MGF?

Mechano Growth Factor (MGF) also known as IGF-1Ec is a growth factor/repair factor that is derived from exercised or damaged muscle tissue, Its called MGF as IGF-1Ec is a bit of a mouthful and harder to identify amongst the other IGF variants.

What makes MGF special is its unique role in muscle growth?

MGF has the ability to cause wasted tissue to grow and improve itself by activating muscle stem cells and increasing the upregulation of protein synthesis, this unique ability can rapidly improve recovery and speed up muscle growth.

MGF can initiate muscle satellite (stem) cell activation in addition to its IGF-I receptor domain which then in turn increases protein synthesis turnover, and therefore can if used correctly improve muscle mass over time.
The liver produces 2 kinds of MGF splice variants of IGF..

1) IGF-1Ec This is the first phase release IGF splice variant and it appears to stimulate satellite cells into activation, This is the closest variant to synthetic MGF.

2) liver type IGF-IE a this is the secondary release of IGF from the liver, and its far less anabolic.

MGF differs from the second variant IGF-IE a as it has a different peptide sequence which is responsible for replenishing the satellite cells in skeletal muscle, in other words it is more anabolic and longer acting than the systematic release of the second MGF liver variant.

So just think of MGF as a highly anabolic variant of IGF. After you have trained, the IGF-I gene is spliced towards MGF then that causes hypertrophy and repair of local muscle damage by activating the muscle stem cells as well as other important anabolic processes, including the above mentioned protein synthesis, and increased nitrogen retention.

In rats some studies have shown muscle mass increases of 20 percent from a single MFG injection.. somehow I think many of these studies are not accurate, however the potential is undeniable.

HOW TO USE MGF

Now when you train what happens to your muscles, they break down, the cells are damaged, muscle tissue needs to be repaired and your body produces 2 forms of MGF splice variant, The first initial release of the above mentioned number 1 variant from the liver helps muscle cell recovery, if there is no MGF then muscle cells die, that's the large and small of it.

As muscle is a post-mitotic tissue and as such cell replacement is not a means of tissue repair , If the cells are not repaired they die and your muscles get smaller and weaker.
The muscle The pool of these stem cells is apparently replenished by the action of MGF, which is produced as a pulse following damage.

Now with synthetic injections of MGF you can increase the pulse and so speed up recovery, and increase the muscle tissue cells by stimulating satellite cells into full maturity. 200mcg bi laterally is the very best choice of dosing in muscles trained.

The only problem with MGF and this is the reason I don't like it, is that it has such a short half life, just a few minutes, between 5-7, and it needs to be used immediately post workout as it wont work if muscle tissue hasn't been damaged, that's why for me personally i think the best option is PEG MGF.
Nevertheless MGF has a huge role to play, and is administered to those with muscle wasting diseases and for those who are elderly and have lost muscle mass for good reason, it is EXTREMELY anabolic.

HOW TO USE PEG MGF

This is a very important section.
When using MGF that's pegylated that's the addition of Polyethylene glycol, its a non toxic additive that increased the half life of MGF from minutes to hours.
This means its uses and versatility make it a tremendous addition to a bodybuilders arsenal.
I have found it most effective as its effects are systematic, that means they have a whole body effect wherever muscle has been damaged or is diseased.

The next aspect we need to look at is how to make the most use of a long acting version of MGF.
When your muscle is damaged your body releases a pulse of an MGF splice variant as i outlined above, followed by a less anabolic longer acting version from the liver... So it seems a waste to inject MGF at this time as you will just blunt your body's own release, your not enhancing it.
So using PEG MGF on non workout days is actually the very best route, the muscle has been damaged, so there are plenty of receptors for MGF, the effects are systematic so all muscles will be helped to recover through increased nitrogen retention, protein turnover, and satellite cell activation. Recovery is just going to sky rocket.
Doing this means your increasing the length of your body's own mechanism for muscle repair and growth, your opening up the anabolic window.

NOW PLEASE TAKE CAREFUL NOTE.
Running PEG MGF in synergy with IGF is perfect but there are things you need to know.
If you dose them at the same time, as IGF has such strong receptor affinity, The effectiveness of MGF will just be wasted.
The best option and the very best choice I feel is this....
IGF DES on workout days Pre workout, or IGF1-LR3 this wont blunt your body's own MGF release from the liver, and whereas IGF1-LR3 has a more systematic effect and only a very small localized anabolic effect, DES on the other hand is very anabolic in a localized way, so bring up lagging muscle parts with DES, and then the following day Dose MGF at 200-400mcg subq to increase recovery and the mechanism for growth. Perfect synergy.

Over a 4 week run i noticed about 4lb increase with the PEG MGF and DES partnership. And roughly the same weight in fat loss, very impressive, some though have noted far greater increases in muscle mass.
If your on an AAS cycle there is no need for the addition of DES as IGF levels will already be elevated, then the addition of PEG MGF can take your recovery and gains to a new level.

What is the best way to store MGF

Dosing 3 times a week is best, and 1ml of BA water for every 2mg is optimal. Storage in the fridge for up to 6 months. Avoid exposure to heat or sunlight.

Kind regards RS

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long r3 igf-1 A good base

long r3 igf-1 A good base

1: Type- IGF-1 Long R3 (Anything else is not as effective, and if the person providing it for you doesn't know anything about it, you are asking for trouble.)
2. Storage- the most popular (and most effective) way to store, transport, preserve IGF is by suspending it in sterile BA in a sterile vial.
This will keep your IGF 99% potent for many months at a time in just about ANY indoor storage, I.E.-closet, drawer, etc. (Take it from me, I stored mine because I wasn't ready to use it for about 6 months in my closet... I had fears about its potency, then I started my first week, and BAM I practically cleaned out the fridge.
3. Use- Usage should not exceed 4-5 weeks, and an OFF period should be about the same. Daily dosages work best (split up into 2 seems to make little difference in the Long R3 version) Most people see results at about 40mcg/day, some use as low as 30mcg/day, and some folks even use 80-100mcg. I SUGGEST to ALL first time users no matter what level, to start at about 40-50mcg/day.
4. Administration- I believe in IM injections over sub q, but either seems to be effective. I like IM better because IM using a slin pin is probably the least painful thing one could imagine, even at two times per day. Also, sub Q shots that contain BA, even diluted BA, can leave little nodules that you may not want to feel on your stomach.
5. Mixing- Most IGF comes suspended in BA. Hopefully it is @ 500mcg/ml or even 333mcg/ml (that would be at 2ml/mg and 3ml/mg respectively) Draw out your desired amount and back load an insulin pin. Add enough bacteriostatic Water to fill the U100 syringe completely.
Some inject immediately before training, while others choose to do 2 shots spread throughout the day... THEY BOTH WORK WELL. Try both; see which method makes your muscles pop out of your skin.
6. Add plenty of protein, and don’t shy away from carbs immediately after training. I used up to 100g of carbs after training, and my body fat went down, all without cardio.

I hope that helps a little, and I’m glad to be lurking around this board again.
More to come.

MORE

The most effective form of IGF is Long R3 IGF-1, it has been chemically altered and has had amino acid changes, which cause it to avoid binding to proteins in the human body and allow it to have a much longer half-life, around 20-30 hours. "Long R3 IGF-1 is an 83 amino acid analog of IGF-1 comprising the complete human IGF-1 sequence with the substation of an Arg(R) for the Glu (E) at position three, hence R3, and a 13 amino acid extension peptide at the N terminus. This analog of IGF-1 has been produced with the purpose of increasing the biological activity of the IGF peptide."

"Long R3 IGF-1 is significantly more potent than IGF-1. The enhanced potency is due to the decreased binding of Long R3 IGF-1 to all known IGF binding proteins. These binding proteins normally inhibit the biological actions of IGF's."

It is also not as expensive since a media grade version is available which is sufficient for bodybuilding use. There is also a receptor grade available but it is VERY expensive and the only noticeable difference between the two would only be able to be noticed in a laboratory setting. The price on the black market for Long R3 IGF-1 can be seen anywhere from $300-$500 per milligram depending on the source, be wary of black market dealers of any IGF since it is a VERY difficult item to obtain. As mentioned IGF is a research product and is only available from a few laboratories in the world and is only available to research companies and biotechnology institutions. For the rest of this article when I say IGF I am now referring to Long R3 IGF-1 for simplicity sake.

There has also been a lot of talk by certain sources claiming to have IGF made by the Eli Lilly company, to clear things up Lilly is a pharmaceutical company and as stated IGF is a research drug and has not yet been approved, Lilly does not and never has manufactured research drugs for retail sale.

The diluents you will need for the IGF are a weak concentration of hydrochloric acid and a sterile buffer (sterile water or bacteriostatic water) the procedure for diluting the IGF is not very difficult, the diluents can be obtained from most local chemical suppliers and a good source of IGF would also be able to supply the necessary diluents.

The most effective length for a cycle of IGF is 50 days on and 20-40 days off. The most controversy surrounding Long R3 IGF-1 is the effective dosage. The most used dosages range between 20mcg/day to 120+mcg/day. IGF is only available by the milligram, one mg will give you a 50 day cycle at 20mcg/day, 2mg will give you a 50 day cycle at 40mcg/day, 3mg will give you a 50 day cycle at 60mcg/day, 4mg will give you a 50 day cycle at 80mcg/day and so on. The dosage issue mainly revolves around how much money you have to spend, plenty of people use the minimum dosage of 20mcg/day and are happy with the results, and in fact several top bodybuilders use the 20mcg/day dosage and are pleased with the results. IGF is most effective when administered subcutaneous and injected once or twice daily at your current dosage. The best time for injections is either in the morning and/or immediately after weight training. R3(long)


by lawnsaver

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Insulin-Like Growth Factor Recombinant 3

IGF1 stands for insulin like growth factor. It mimics insulin in the human body and also at the same time makes the muscles more sensitive to insulin’s effects. It is a growth factor and is the most potent one in the human body at that. IGF1 causes muscle cell hyperplasia, which is an actual splitting and forming of new muscle cells. This was thought to only be possible during puberty. IGF1 is much more potent at this effect than growth hormone is, in fact almost all of the effects you see from growth hormone come from the increased amount of IGF1 that your liver produces when the GH is destroyed. So it would be very easy to say that IGF1 is a much more potent and cheaper alternative to GH use, although GH is more effective for fat loss than IGF1 due to some other effects that it causes such as metabolism increase and the ability to effectively use more insulin, T3, and anabolic steroids.

Another advantage that IGF1 has over GH is that it has much more of an affinity to attach to muscle cells instead of bone and organ cells. Growth hormone has been know to cause a lot of organ enlargement and bone elongation since it attaches to all types of receptor cells. IGF1 is much more likely to go where we want it, our muscle cells. IGF1-1 attaches to myogenic stem cells which are only located in muscle and connective tissues. These myogenic stem cells are responsible for the production of myoblast cells which in turn are responsible for the buildup and repair of connective tissues (ligaments, tendons, cartilage, and joints to a certain extent).

So from this you can see that IGF1-1 is great for increasing the strength of tendons and also for helping to heal existing injuries while at the same time helping to prevent them. IGF1-1 is also responsible for increased protein synthesis and amino acid synthesis.

IGF1 does not have to be used along with anabolic steroids, GH, insulin, or thyroid hormones to be effective. It causes muscle growth on its own. In fact some people prefer to use it during their breaks from steroid cycles since IGF1 has no effect on natural test production. It could effectively be used along with HCG, clomid, and PGF2a for a hell of an off cycle stack which would allow your body to return to normal and still allow you to grow!! On its own IGF1 will give an increase of around 2 lbs. of new solid lean muscle tissue every two weeks, and is also is know for its ability to strip off body fat and GREATLY increase vascularity, body fat decreases of 5-8% over a 50 day cycle are not uncommon. But, of course you will be much happier with the results if you use the IGF1 along with anabolic steroids, testosterone, and insulin.

The use of steroids along with the IGF1 allow you to quickly mature and strengthen the new muscle tissue that the IGF1 has formed, and may also speed the process of hyperplasia. If you need any help setting up a great stack to
use along with the IGF1 just let me know and I can help you out. I speak with lots of top bodybuilders and guru’s so I am very knowledgeable.

The dosage issue for IGF1 is where the most controversy lies. Dosages used by competitive athletes most commonly range anywhere between 60mcg/day to 100+mcg/day. The trick is finding the dosage that works best for YOU. For most the best results appear when you reach a dosage of 80mcg/day, while some do
receive good results from only 40mcg/day. I personally feel the best results begin to be noticed at a dosage of 100mcg/day. I personally am using 150mcg/day during my current cycle.

Also I should let you know that the form of IGF1 is the Long R3 analog. It has been chemically altered and has a longer half-life than regular IGF1, which only lasts about 10 minutes in the human body once injected. The Long R3 IGF1-1 has a half-life of 6-10 hours, so you will only need to inject once or twice per day. The best time to inject is after lifting and in the morning, so it would be best to use half the dosage in the morning and the other half after lifting. This will take maximal advantage of IGF1’s insulin
mimicking effects.

As posted by: WarLobo

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