Healing Peptide Thymosin Beta 4 – TB500

Explanation and common uses of TB-500:

Thymosin Beta 4 is the thymosin peptide shown to promote protection, growth, repair, remodeling and healing. Studies have shown that it can promote migration of cells, formation of blood vessels, maturation of stem cells, activation of progenitor cells, survival of various cell types and lowering of the production of pro-inflammatory cytokines. Thymosin Beta 4 is the form that is naturally produced within the human body and obviously cant be bought. The synthetic form of Thymosin Beta 4 that is synthesized and manufactured is called TB-500 ie this is what can be bought, injected etc. There is no difference in efficacy between the two

Buy your tb-500 here

Thymosin Beta 4 Dose:

Dosage depends on the purpose and severity of the injury / damage you are treating. People generally use between 4 to 8 mg of TB500 per week during the initial (loading) period of 4 to 6 weeks. Afterwards some opt to maintain the effects with a low 2 to 6 mg dose once every 2 weeks. The effects of TB-500 wear off within 2 – 3 weeks of injection.

How to take Thymosin Beta 4:

1. Get the tops of your vial and bacteriostatic/sterile water vial off.
2. Using an alcohol pad, clean the top of both vials (tb-500 and water)
3. Using a new sterile insulin syringe, draw syringe full of air(1ml) and inject it into the bacteriostatic vial then withdraw 1ml of bacteriostatic water.
4. Inject this 1ml of bacteriostatic water into the side of the tb-500 vial. Don’t force it and don’t spray it onto the lyophilized powder but rather into side of the vial so that the powder merely dissolves into it.
5. You can repeat step 3 and 4 if you are going to dilute the powder using more than 1ml eg 2ml
6. Check to see that all powder has dissolved and gently roll vial to ensure it has all dissolved well. DO NOT SHAKE.
7. If you want to equalize the pressure inside the vial you can pierce it with your insulin syringe but with no plunger in it
8. Withdraw appropriate amount of the now dissolved tb-500 into your syringe, try and avoid any major bubbles by tapping side of syringe and adjusting plunger. Ready for injection. (You can use a brand new syringe if you want the needle to be sharp and use the one that you pierced the rubber tops of your vials with to simply fill/load the new syringe with)


Duration:
1. Thymosin Beta 4 loading phase:

• duration: between 4 – 6 weeks
• dosage: between 4 – 8 mg of TB-500 per week
• frequency of injection:2 mg per injection, between 2 – 4 times per week (depending on the total weekly dosage)

TB-500 maintainance phase:

• duration: as long as needed
• dosage: between 2 – 6 mg of TB-500 per 2 weeks
• frequency of injection:2 mg per injection, between 2 – 3 times per 2 weeks (depending on the total bi-weekly dosage)

Dilution:
BA water

Side effects of Thymosin Beta 4 :

There have been no reported side effects during the past few years since TB-500 became popular by athletes. For some reason people expect the TB-500 to produce flu-like symptoms. After thorough research through every Thymosin beta-4 related usage log on bodybuilding forums, there are simply no reports to confirm any side effects.

HOW TO USE TB-500 Thymosin beta 4 for healing benefits

Research has shown that the best results are achieved when using sterile saline solution (Sodium Chloride Injection BP 0.9%) to mix TB-500 (thymosin beta4).


Important:
Only prepare the vials that will be used immediately. If using doses that are lower than the recommended dose, prepared vials must be stored in the fridge and be used within 8 days.


TB-500 preparation:
Remove the plastic protective cap of the sealed vial containing the powder of peptides.
Insert the filled syringe of 2ml of sodium chloride solution into the rubber top of the vial and release the 2ml of sodium chloride into the vial.
Remove the syringe and gently rotate the vial until the powder is completely dissolved.
Ensure that the solution is well mixed with all powder thoroughly dissolved for maximum safety and effectiveness.


TB-500 Administration:
A Subcutaneous (S/C) inj.


TB-500 Frequency:
Research studies have further shown that one (2ml. vial) Sub-Q Inj. each week for six consecutive weeks provides the best results.  There after, use only one (2ml. vial) per month.  It’s best to give the Sub-Q Inj. 6 days before intense work outs. Therefore for best results, one vial per Sub-Q injection per week for 6 consecutive weeks, then 1 vial per month (the glass vial is 2ml, with 10mg TB-500 per vial), so it is 10mg/2ml).


Contraindications:
No known contraindication with tb4 peptide products, however tb500 has not been thoroughly tested to know its full effects.
The product should not be used if the subject is pregnant or breast feeding.


TB500 Storage:
Store the product at room temperature in a non humid environment. An opened vile can be kept for up to 8 days in refrigerated storage.

What is TB-500?TB-500 is a synthetic version of the naturally occurring peptide present in virtually all human and animal cells, Thymosin Beta 4 (TB-500). It is a first-in-class drug candidate that promotes the following*:
•  Endothelial (blood vessels) cell differentiation
•  Angiogenesis (growth of new blood cells from pre-existing vessels) in dermal tissues
•  Keratinocyte migration
•  Collagen deposition; and
•  Decreases inflammation.
One of TB500 key mechanisms of action is its ability to regulate the cell-building protein, Actin, a vital component of cell structure and movement. Of the thousands of proteins present in cells, actin represents up to 10% of the total proteins which therefore plays a major role in the genetic makeup of the cell.


This potent peptide is a member of a ubiquitous family of 16 related molecules with a high conservation of sequence and localization in most tissues and circulating cells in the body. Thymosin beta-4 not only binds to actin, but also blocks actin polymerization and is the actin-sequestering molecule.


Tß4 was identified as a gene that was up-regulated four-to-six fold during early blood vessel formation and found to promote the growth of new blood cells from the existing vessels. This peptide is present in wound fluid and when administered subcutaneously, it promotes wound healing, muscle building and speeds up recovery time of muscles fibres and their cells.
An additional key factor of TB500 is that it promotes cell migration through a specific interaction with actin in the cell cytoskeleton. It has been demonstrated that a central small amino acid long-actin binding domain has both blood cell reproduction and wound healing characteristics. These characteristics are uncovered by accelerating the migration of endothelial cells and keratinocytes. It also increases the production of extracellular matrix-degrading enzymes.
Research confirms that TB500 is a potent, naturally occurring wound repair factor with anti-inflammatory properties. TB-500 is different from other repair factors, such as growth factors, in that it promotes endothelial and keratinocyte migration. It also does not bind to the extracellular matrix and has a very low molecular weight meaning it can travel relatively long distances through tissues.