Humalog - fast acting insulin for bodybuilding

Humalog - fast acting insulin for bodybuilding


Humalog Insulin (Fast Acting)
Substance: insulin
Delivery: 10ml vial (40IU/1ml)
Average Dose: 1iu per 15 - 20 pounds bodyweight
Half Life: 1.5 - 3 hours
Water Retention: Yes
Aromatization:
DHT Conversion:

Insulin is a powerful hormone in the human body, responsible for regulating glucose levels in the blood. This is a function that your life constantly depends on. Before going any further I must stress that insulin use by those who do not medically require it can be a very risky endeavor. It is important not only to research and understand the risks involved, but to really give some thought to just how important a little extra boost is to you. Misusing insulin can have tragic results. Immediate death, coma or the possible development of insulin dependent diabetes in a previously healthy athlete are all possible, be extremely careful.

In the human body insulin is secreted by the pancreas. The release of this hormone is most closely tied to glucose, although a number of other factors including pancreatic & gastrointestinal hormones, amino acids, fatty acids and ketone bodies are also involved. Its role in the body is to control the uptake, utilization and storage of amino acids, carbohydrates and fatty acids by various cells of your body. The activity of insulin is both anabolic and anti-catabolic, the hormone stimulating the use and retention cellular nutrients while inhibiting their breakdown. Skeletal muscle cells are among the many targets of this hormone's action, and the reason pharmaceutical insulin has made its way into the realm of athletics. But this is a little tricky because insulin can also promote nutrient storage in fat cells, obviously an unwanted result. Athletes have found however, that a strict regimen of intense weight training and a diet without excess caloric intake can result in insulin showing a much higher affinity for protein and carbohydrate storage in muscle cells. This could produce rapid and noticeable growth, the muscles beginning to look fuller (and sometimes more defined) almost immediately after starting insulin therapy.

The fact that insulin use cannot be detected by urinalysis has ensured it a place in the drug regimens of many professional bodybuilders. Insulin is often used in combination with other "contest safe" drugs like human growth hormone, thyroid medications and low dose testosterone injections, and together can have a dramatic effect on the users physique without fear of a positive urinalysis result. Those who do not have to worry about drug testing however, find insulin and anabolic/androgenic steroids a very synergistic combination. This is because the two actively support an anabolic state through different mechanisms, insulin enhancing the transport of nutrients into muscle cells and steroids (among other things) increasing the rate of cellular protein synthesis.

The actual medical purpose for insulin is to treat different forms of diabetes. Specifically the human body may not be producing insulin (Type-I diabetes) or may not recognize insulin well at the cell site although some level is present in the blood (Type-Il diabetes). Type-I diabetics are therefore required to inject insulin on a regular basis, as they are left without a sufficient level of this hormone. Along with medication, the individual will need to constantly monitor blood glucose levels and regulate their sugar intake. Together with lifestyle modifications such as regular exercise and developing a balanced diet, insulin dependent individuals can live a healthy and full life. Untreated, diabetes can be a fatal disease.

As we have discussed earlier, regular insulin is the most popular choice and will be the subject of our intake discussion. Before one even considers using insulin, they should become very familiar with using a glucometer. This device gives you a quick number reading of your blood glucose level and can be indispensable in helping you manage your insulin/carbohydrate intake.

Insulin is used in a wide variety of ways. The dosages can vary significantly among athletes, and are often dependent upon factors like insulin sensitivity and the use of other drugs. Most users choose to administer insulin immediately after a workout, which is likely the most "anabolic" time of the day to use this drug. Insulin is always injected subcutaneously, or below the surface of the skin but without entering muscle tissue. This is given by pinching a fold of skin, commonly in the arm or abdominal area. A small "insulin needle" is used, approximately ?รข€ long, 27-29 gauge thickness and holding one third to one full cc. These are available over-the-counter in many states. A full cc (or ml) equates to 100 international units (l.U.), a scale that is clearly labeled on an insulin syringe. It is important that the injection site be left alone after insulin has been injected and not rubbed. This is to prevent the drug from releasing into circulation too quickly. It is also a good idea to rotate injection sites regularly; otherwise a localized buildup of subcutaneous fat may develop due to the lipogenic properties of this hormone.

Among bodybuilders, dosages used are usually in the range of 1IU per 15-20 pounds of lean bodyweight. First- time users should at first ignore body weight guidelines however, and instead start at a low dosage with the intention of gradually working up to this point. For example, on the first day of insulin therapy you could begin with a dose as low as only 2 lU. Each consecutive post-workout application this dosage can be increased by 1 IU, until the user determines a comfortable range. This is safer and much more tailored to the individual than simply calculating and injecting a dose, as many find they tolerate much more or less insulin than weight guidelines would dictate. Athletes using growth hormone in particular often have higher insulin requirements, as HGH therapy is shown to both lower secretion of, and induce cellular resistance to, this hormone.

One also must remember that it is very important to consume carbohydrates for several hours following insulin use. One will generally follow the rule-of-thumb, of ingesting at least 10 grams of simple carbohydrates per IU of insulin injected (with a minimum immediate intake of 100 grams regardless of dose). This is timed approximately 20 to 30 minutes after the drug has been administered. The use of a carbohydrate replacement drink such as Ultra FueK by Twin Labs would probably be a good idea, as this is a fast and reliable carbohydrate source. It is best to always have something like this on-hand should you begin to notice too low a drop in glucose levels. Many athletes will also take creatine monohydrate with their carbohydrate drink, since the insulin may help force the creatine into the muscles. An hour or so after injecting insulin, one will eat a good meal or consume a protein shake. The carbohydrate drink and meal/protein shake are absolutely necessary. Without them, blood sugar levels can drop dangerously low, and the athlete will most likely enter a state of hypoglycemia.

Many taking insulin will also notice a tendency to get sleepy some time after injecting the drug. This is an early symptom of hypoglycemia, and a clear sign the user should be consuming more carbohydrates. One should absolutely avoid the temptation to go to sleep at this point, as the insulin may take its peak effect during rest and blood glucose levels could be left to drop significantly. Unaware of this condition during sleep, the athlete may be at a high risk for going into a state of severe hypoglycemia. We have of course already discussed the serious dangers of such a state, and unfortunately here simply consuming more carbohydrates will not be an option. Those experimenting with insulin would therefore be wise to always stay awake for the duration of the drug's effect, and also avoid using insulin in the early evening to ensure the drug will not be inadvertently active when retiring for the night.

Many athletes prefer to bring their insulin with them to the gym, injecting in the locker room (or car) immediately after a workout. Although insulin should be refrigerated, it is fine to keep it in a gym bag or car so long as it is not left out for too long and it is kept away from heat/direct sunlight. Rather than waiting to the end of a workout, some actually prefer to inject their insulin dosage during training, 30 minutes prior to the end of a session. Immediately following the workout the user will consume a carbohydrate drink in this case. Such timing may make the insulin more efficient at bringing glycogen to the muscles, but also increases the danger of hypoglycemia as carbohydrate consumption may be inadvertently delayed. Some will go so far as to inject a few units before lifting to improve their pump. This practice is risky and best left to those very experienced with insulin. Finally, some bodybuilders opt to inject insulin upon waking in the morning. After the injection they will consume a carbohydrate drink. Later, perhaps one hour after the injection, a full breakfast will be consumed. Some athletes find this application of insulin very beneficial for putting on extra mass while others will tend to store excess fat. If using more than one application of insulin per day it would also be a good idea to restrict the total daily intake to no more than 20-40 IU.

Remember to be very careful, one mistake in dosage or diet can be potentially fatal

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What is PEG-MGF?


What is PEG-MGF?

PEG-MGF, or PEGylated Mechano Growth Factor is a new and innovative form of MGF that outperforms natural MGF many times over. MGF is a splice variant of the IGF gene which increases stem cell count in the muscle and allows for muscle fibers to fuse and mature. This is a process required for growth of adult muscle. Natural MGF is made locally and does not travel into the bloodstream.
 Synthetic MGF is water based and when administered intramuscularly, travels into the bloodstream. MGF is only stable in the blood stream for only a few minutes.   PEGylation is the act of attaching a Polyethylene glycol (PEG) structure to another larger molecule (in this case, MGF). The PEG acts as a protective coating and the theory here is that this will allow the MGF to be carried through the blood stream without being broken down.

MGF exhibits local effects in skeletal muscle and without cannot travel through the body without modification. The problem with synthetic MGF is that it is introduced intramuscularly and is water based so it goes into the blood stream. When used this way, MGF only remains stable in the blood stream for a few minutes.
 Biologically produced MGF is made locally and does not enter the bloodstream. It is also short acting so stability is not an issue. By PEGylating the MGF it is almost as efficient as local produced MGF when used intramuscularly. This is accomplished by surrounding part of the peptide with a structure of polyethylene glycol, which can be attached to a protein molecule. The polyethylene glycol groups protect the peptide but don’t surround it completely.
 The active sites of the peptide are still free to do their biological function. In this case the shell is a negative charged shield against positively charged compounds that would affect the protein.

Neurological research has shown that utilizing PEGylated MGF resulted in a longer more stable acting version of the MGF peptide in serum/blood

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Melanotan 2 information


Melanotan 2 information

Melanotan II is a cosmetic sunless tanning product that stimulates melanin production. Melanin is the main determinant of skin color in humans, a brown pigment which causes skin to become darker in appearance, instead of red when exposed to UV rays. Melanotan II users develop a gradual, natural looking tan with minimal exposure to the sun. It is particularly useful for fair-skinned individuals who find that they cannot tan naturally in the sun.

Melanotan 2 peptide is not a treatment or cure for any disease, nor should it be used with the aim of preventing skin cancer. While melanin is known to have excellent photo protective properties, no clinical studies have ever indicated the efficiency of Melanotan II specifically in reducing UV damage.


It is estimated that more than 90% of Melanotan users are familiar with the injectable Melanotan II. Melanotan I is usually only preferred by a small amount of long-term users who feel that Melanotan II makes them too dark, nauseated, and/or those who find the aphrodisiac side effect of Melanotan II to be a nuisance. These problems can be avoided by taking Melanotan II in lower dosages, administering before bed and using sunscreen and clothing to control tanning.

Since Melanotan I has a large body of clinical evidence supporting its safety and efficacy, new users in particular often feel that it would be the better and safer option for usage. Unfortunately this is not the case when it comes to skin darkening and most new users who choose Melanotan I find themselves very disappointed at lack of tanning results since Melanotan I is not intended to be used for this purpose. To achieve similar cosmetic tanning results as seen with Melanotan II, a dose of 10x more per injection is required. Melanotan I is more expensive for tanning.
Melanotan II Storage

In ****** (lyophilized) form vials should be stored at refrigerator temperature (2-8 degrees Celsius) where they will remain stable for up to 12 months. Reconstituted (mixed) vials should also be stored in the refrigerator, but use within 8 weeks or they may begin to degrade. They will still be safe to use after this time, but they may not be as effective as new vials.
When to take Melanotan II

The frequency of Melanotan II injections will depend largely on your skin type to begin with, therefore you should identify with which Fitzpatrick skin type you are

Type 1: Pale skin, many freckles, blue/green eyes, red hair, never tans, always burns
Type 2: Fair skin, few freckles, blue/hazel eyes, blonde/sandy hair, tans poorly, usually burns
Type 3: Darker white skin, brown hair/eyes, usually tans, rarely burns
Type 4: Light brown skin, darker brown hair/eyes, tans easily, burns minimally
Sunless Tanning

Loading: Take your Melanotan II dose 1 time per day and continue with daily injections until you are happy with the color of your tan.
Maintenance: To maintain your desired tan, inject your Melanotan II dose just 2-3 times per week Cessation: You can continue the maintenance dosing indefinitely; however, if you choose to stop your Melanotan II injections, your tan will fade back to its pre-Melanotan II shade in 1-2 months.

Assuming the right amount of UV exposure (sun or sun bed) is combined with your Melanotan II usage, then the amount of time it takes to achieve your desired tan (i.e. the loading phase) will usually take 4-8 weeks for skin types 1 and 2 and as little as 2-3 weeks for skin types 3 and 4.

Melanotan II and UV Exposure
The tanning activity of Melanotan II without the need for UV exposure has been proven by clinical trial; however, the majority of users report that results are achieved much quicker, and that the tan is a more natural color, when Melanotan II is combined with a small amount of UV exposure.

Tanning should start after the third injection and occur 2-3 times per week if you wish to see tanning results quickly; otherwise one tanning session per week is sufficient to gradually build your tan
Melanotan Advice

If you are not seeing results then you need to increase the frequency of your outdoor or indoor UV exposure (especially if you are skin types 1 or 2). Never increase your recommended Melanotan II dose.

Tanning sessions should be short, 5-10 minutes in a sun bed or 30-40 minutes in the sun on a warm day is sufficient each time. DO NOT overexpose yourself to UV rays.

When starting out always use 30+ sunscreen on sensitive areas such as the face and neck. Because these areas are frequently exposed to UV rays they are more responsive to the melanin producing effects of Melanotan II and therefore will become darker quicker than the rest of the body. Covering these areas initially will allow other parts of the body to tan first, ensuring you achieve a well balanced tan.

Melanotan II and UV exposure complement each other, so if you spend a lot of time tanning you will need less frequent injections of Melanotan II to obtain and maintain your tan. If you don't spend much time in the sun or sun beds then you will need frequent dosages of Melanotan II to develop and keep your tan ..

Fair skinned folks who never tan, always burn in the sun, can achieve a natural tan when using Melanotan 2. For people with sun allergies these discoveries are life changing. The best defense against skin cancer is a natural tan developed over time. MT-2 was designed to reduce skin cancer rates and be effective as a sunless tanner.

Athletes and fitness enthusiasts use Melanotan for sunless tanning, Libido increase and and appetite suppression. MT-2 was dubbed the Barbie drug and has been highlighted in wired magazine. Synthetic melanocortin use helps attain a tan with the least amount of exposure to harmful ultraviolet radiation.
Fitzpatrick skin type: Skin type I and II, the lower of the skin types on the Fitzpatrick scale are the best candidates for Melanotan 2 who see the most dramatic results.

Treatment: Melanotan stimulates melanin effectively, in particular those with low skin types.


Shipping and Handling: Melanotan Peptides are durable and stable. Highlighted in study, the reconstituted MT-2 was shown to be stable at 37 degrees Celsius (98 degrees Fahrenheit) for at least 28 days. Shipping MT-2, even in summer months, is not a problem. Do not pay for cold shipping as it is not a premium. When receiving MT-2 it is recommended to store in the refrigerator.

Mixing: Add BW to the vial when you are ready to begin MT-2 research.

Remove plastic flip top from vial to expose rubber stopper. needle will pierce the stopper making way inside the vial to turn the white ****** into a clear liquid.

Calculator: Add 100 units (1ml) of water to the vial. 1ml/100 units will minimize the volume that you have to inject and will simplify the arithmetic in your MT-2 experiment. Dosing measurements are often mentioned in both milligram (mg) and microgram (mcg). Example: .5mg = 500mcg
Peptide Measurement

1ml syringe (U100), 1ml BW to reconstitute
Calculations for a desired 0.5mg dose:
Step 1= 1ml
Step 2= 10mg MT-II
Step 3= 1ml bac water
Step 4= 500mcg dose
2-3 ticks on your insulin pin (approximately 1/20th of a U100 syringe)

Some prefer to add more diluent which works fine, take note of the volume increase.

Needles: 29-31 gauge X 1/2", 1 CC (100 unit). That is a typical insulin needle used to mix as well as inject. Use needles one time only. Once your technique perfected, injections are almost painless.

Starting dose: Your first injection should be a very small dose, for example .25mg (250mcg). See how you react. Goal should be to feel nothing. Dose after dinner, before bed. Any dosing chart stating that you should take a high dose (according to your weight) is outdated and potentially dangerous.

Loading dose: Load with 0.5-1mg once a day. People who have used doses in this range generally report getting excellent results. Don’t worry if you miss occasional days. It will not make much difference, focus on the cumulative effects.

Maintenance dose: Maintenance is taking doses less frequently than daily to avoid becoming darker than you want. Yes, that will happen. With enough UVR, you will get much darker than you have even been before. A maintenance dose can help prolong super-physiological photo-protection MT-2 delivers.

UV Radiation: Melanotan is a poor sunless tanner. UV (from sun or a tanning bed) light is necessary to develop a tan. Without it, almost nothing happens. In other words, NO UV = NO TAN. Well, user will pigment depending on skin type.... If you have loaded for a full month and then start UV exposure, you (and your friends) will be astounded by how fast you tan and how dark you get. Moreover, it is advisable to keep areas of your skin that ordinarily get exposure covered up with a towel and/or zinc oxide (nose/lips/face) and let less exposed areas develop pigmentation first. Areas of skin that are typically sun-exposed in your day to day life will respond more readily to the effects of the Melanotan Peptides.

Fat Loss: The melanocortin (MC) system is a signaling pathway for leptin and insulin. The MC system is important for control of food intake and body weight. MT-2 treatment results in adipocyte lipolysis. MT-2 increases fatty acid oxidation(FAO) in which the MC5R plays a significant role. MT-2 improves insulin sensitivity through stimulating FAO in skeletal muscle tissue. Reduced food intake from the anorectic response of MT-2 is primarily responsible for weight loss.

Watch yourself: Your tan can sneak up on you. A tan generally sets in 3 days after UV rays. Dose and expose yourself gradually to UVR when tanning. Love your skin.

Avoid burning: You are protected from burning mostly by your tan, not the MT-2 peptide. Therefore, don’t overdo the rays at first. Start with only as much UV that you could tolerate without burring before you began Melanotan. It should not take many weeks before you can tolerate hours of strong sun without burning. Truly incredible for those who have never experienced freedom to enjoy the sun.

Continue your regular dosing protocol until you have reached your desired tan and do not want to become darker. Cut injection frequency to once every 2, 3, 4, or even 7 days. Experiment to find the frequency that gives the tan you want.

Storage: Store freeze dried and reconstituted (mixed) Peptides in the refrigerator.

Do you have to inject MT-II?
Yes. The best, most efficient method of administering Melanotan Peptides are subcutaneous (subq) injections. Nasal sprays are inconsistent and inefficient. No detectable levels were observed following oral dosing - pills do not work.

when you start supplementing (Melanotan II) to tan keep in mind that tanning is literally a side effect. The tanning response is, in reality, a physiological repair mechanism to instant UV damage of the skin cells (. Melanocyte stimulating hormone is not going to color your skin, it is going to make your own skin create its own tan and that in turn creates protection. If you are looking to be some bronzed beach God with perfectly uniform and specific color then you are better off to going to mystic tan. Redheads, for example, naturally produce a variant form of melanin that is yellowish-red . Do not expect a brown tan on a ginger body right away.

Know your skin type: Knowing your skin type is just one detail which will help create a public user log. There are 10s of thousands of Melanotan users worldwide who share the experience. Raise awareness and help others who want to hear success stories, complications and failures.
Am I a good candidate for MT-II?
Melanotan is best suited for the folks with skin types I & II. Prior sun damage, scars, tattoos, freckles, moles, hair color, etc are deciding factors prospective MT-2 users consider.

How should I dose MT-II?
Melanotan II dosage it is recommended to start out small and build up. A typical starting dose is around .25mg and max dose reaching 1mg. Desensitization happens quick, the first administration is an opportunity to dose low to avoid Melanotan 2 side effects. Same goes for Bremelanotide (PT-141) dosage unfortunately.

Melanotan Instructions: There is no magic pill or formula. Instructions do not exist for research Peptides. Few dermatologists are familiar with Melanotan. The skin is a large, unpredictable organ. Feel comfortable and confident with MT-II before use. Check out as many before and after photos and user logs as you can. A skin type I individual may have to commit months of dedication before dialing in their desired results, be patient and ask questions.

How much MT-II should I buy and how long will it last?
Skin type I: 30-50mg
Skin type II: 20-30mg
Skin type III: 10mg
Should last entire summer or season

How soon will I begin to see results from Melanotan II?
You should notice a change in your skin tone after three weeks. If you have freckles, expect them to get darker before your actual skin color changes.

How long will the tan last?
A tan developed using Melanotan 2 lasts much longer than an ordinary tan. A well-tanned person returning from a beach holiday will lose most of the tan in a month if they stop getting sun. But if they had been using Melanotan 2 and continued on maintenance after returning, they would still have most of their tan 3 months later.

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Bremelanotide (PT-141)


Bremelanotide (PT-141)


Bremelanotide PT-141 Dose:

Light: .5mg
Common: 1mg
Large: 2mg

Bremelanotide (PT-141) was developed from Melanotan 2 (MT-II). PT-141 is a metabolite of melanocyte stimulating hormone that targets desire.

Treatment: PT-141 is the only synthetic aphrodisiac. The aphrodisiac effects of Bremelanotide are in a class of its own. Studies have shown Bremelanotide to be effective in treating sexual dysfunction in both men (erectile dysfunction or impotence) and women (sexual arousal disorder). Nine out of ten volunteers experienced sexual arousal in clinical trials. Unlike Viagra and other related medications (PDE5s - blood pushers), PT-141 acts upon the nervous system. Viagra, Cials and Levitra are not considered aphrodisiacs as they do not have any direct effect on the libido. However, treatment with PDE5 inhibitors and PT-141 have known synergy.

Men's Journal Magazine: ...it took hold. I felt a great surge of affection (greater than any regular level of arousal). My body tingled and I developed an erection that wouldn’t quit. For two hours the drug wouldn’t let me out of its grasp — nor my wife out of mine. -Frederick Kaufman

Females: Women who took part in trials said that they felt a "tingling and a throbbing" along with "a strong desire to have sex." An initial flush occurs post injection, followed by nausea which is dose dependent. For most, effects generally do not take place until a couple hours post injection, peaking around the four hour mark. Men said PT-141 made them feel "younger and more energetic" as well as sexually interested and aroused. "You're ready to take your pants off and go," said user "a drug that makes you not only able to but eager to."

Bremelanotide PT-141 Peptide: Bremelanotide comes in 10mg vials. As a lifestyle peptide, the 10mg product is a lot to consume and may offer up to 20 doses when dosing light. The PT-141 peptide reconstituted with bacteriostatic water remains potent in the fridge for months.

Window of Opportunity: Bremelanotide, injected (subcutaneously), has a unique window of opportunity lasting six to 72 hours. In lab trials female rats exposed to PT-141 began "flirting" with male rats for sex. Postures and movements left no doubt in the male rats minds that they were in the mood. The human PT-141 date is one where the dosage precedes the activity by at least a couple hours. When the stars align, hours after the injection, ...this is your window of opportunity, enjoy.

Mixing: Bacteriostatic water is used for reconstitution.

Example- 1ml(cc) bacteriostatic water per 10mg PT-141 vial equates to a 1mg dose approximately each 10 units on a U100 insulin syringe.
Example- 1ml(cc) bacteriostatic water per 2mg PT-141 vial equates to a 1mg dose approximately every 50 units on a U100 insulin syringe.

Recommended strategy for mixing and dosing would be to reconstitute with the volume that yields a .1ml injection.

Example- 1ml(cc) bacteriostatic water per 10mg PT-141 vial equates to a 1mg dose approximately each 10 units on a U100 insulin syringe.
Example- .2ml(cc) bacteriostatic water per 2mg PT-141 vial equates to a 1mg dose approximately every 10 units on a U100 insulin syringe.

Dosing: Read as much as possible to gain clarity and align expectations. Gradually dosing increases likelihood for success without sides. A test dose of .25-.5mg on the first attempt is recommended. 1mg, give or take a quarter, is the efficacious dose which yields the most positive reports by users.

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Complete Idiots guide to reconstitution of Peptides


Complete Idiots guide to reconstitution of Peptides
 


 For IGF you use an acetic acid solution. If one was not made available to you can make the solution using 7 parts distilled water and 1 part vinegar from the grocery store. You must filter this through a sterile syringe filter before use however.

For MGF use bacteriostatic water BW.

For HGH Fragments and GHRP's also use BW.

When reconstituting you are going to add the liquid to th vial containing the powder is a slow controlled manner with the vial tilted so that the liquid trickles out of the needles and rolls down the side of the vial. Do not squirt it directly into the peptide b/c this may damage it.

How do you know how much to use?
Well you need to know how much is in the vial and how much you want your dose to be. I like to make mine so that the dosage comes out to being an even 10IU so its easy to measure accurately.

You will need insulin syringes with IU (international units) measurements.
and IU is 1/100 of a mL or a 100,000 of a Liter. This is a measurement of volume.

You peptide will be labeled in mcg. (micrograms) which is 1/1000 of a mg or 1 millionth of a gram.

Your vial will likely have either 1 or 2 mg of peptide inside that's 1000-2000 mcg.

Say you have a 1mg vial and you add 1ML you get
1000mcg/1mL: 10 mcg per IU
and so on if you add more.
1000mcg/2mL: 5.0 mcg per IU
1000mcg/3mL: 3.3 mcg per IU
1000mcg/4mL: 2.5 mcg per IU

if you have a 2mg vial simply multiply these number by 2
2000mcg/1mL: 20 mcg per IU

Now you are not going to be able to accurately measure 1 IU. I'd say 5 IU is the smallest measurement I would recommend and 10IU is even easier to measure. So lets look at these dilutions for 5 and 10 IUs
1000mcg/1mL: 100 mcg per 10IU
and so on if you add more.
1000mcg/2mL: 50 mcg per 10IU
1000mcg/3mL: 33.3 mcg per 10IU
1000mcg/4mL: 25 mcg per 10IU

Or
1000mcg/1mL: 50 mcg per IU
and so on if you add more.
1000mcg/2mL: 25 mcg per IU
1000mcg/3mL: 16.6 mcg per IU
1000mcg/4mL: 12.5 mcg per IU

Once again if you are using a 2mg vial just multiply these numbers by 2.

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What types of Growth Hormone Releasing Hormones are there


What types of Growth Hormone Releasing Hormones are there

Growth Hormone Releasing Hormones (GHRH) (amplifies the Growth Hormone Releasing Peptides (GHRP) initiated pulse):
- GRF(1-44) - half-life is less than 5-10 minutes
- GRF(1-29) Sermorelin - half-life is less than 5-10 minutes
- Modified GRF(1-29) or CJC-1295 w/o the DAC - Half-life at least 30 minutes
- CJC-1295 (with DAC) - Half-life measured in days

Growth Hormone Releasing Hormone (GHRH) pulses can only last less than 30 minutes before your body has used out the potential for a single growth hormone pulse. Since another pulse won't be generated for about 2.5 - 3 hours hormones that last more than 30 minutes up to 3 hours are not any more beneficial.

The administration of Growth Hormone Releasing Hormone (GHRH) creates a pulse of growth hormone release which will be small if administered during a natural growth hormone trough and higher if administered during a rising natural growth hormone wave.

What types of Growth Hormone Releasing Peptides are there?
Growth Hormone Releasing Peptides (GHRP) (Growth hormone pulse initiators):
- Ipamorelin is potent but the weakest growth hormone releaser. It does not increase cortisol or prolactin at any dose.
- GHRP-6 is very potent in effecting growth hormone release. It does not effect cortisol or prolactin up to a 100mcg dose, but does so minimally above 100mcg.
- GHRP-2 is a little bit more potent then GHRP-6. It also has a stronger effect on these hormones at all dosing levels rising to the high normal range for cortisol and prolactin.
- Hexarelin the strongest is a little more potent then GHRP-2. At all dosing levels it has the strongest impact on cortisol and prolactin with levels in the upper bounds of normalcy.

Growth Hormone Releasing Peptides (GHRP) can become desensitized with constant usage throughout the day. Ipamorelin and GHRP-6 do not desensitize as long as there are short breaks between doses minimal 2 hours. GHRP-2 does not desensitize in the lower dose ranges without short breaks. At high dose it is unclear, but some desensitization may occur. Hexarelin has been shown to desensitize without regard to dose and even with short breaks between doses. This effect shows up after 14 days of continuous use and may be avoided by either keeping doses low or taking a full day or two off every two weeks.

Growth Hormone Releasing Peptides (GHRP) are capable of creating a larger pulse of growth hormone on their own than Growth Hormone Releasing Hormone (GHRH) and they do this with much more consistency and predictability without regard to whether a natural wave or trough of growth hormone is currently taking place.

How much Growth Hormone Releasing Hormone (GHRH) should be used?
The saturation dose in most studies is defined as 100mcg or 1mcg/kg per growth hormone pulse.

How long should Growth Hormone Releasing Hormone (GHRH) be used?
In most studies no adverse side effects were reported with use for 4-8 weeks (per the dosage limits in the above answer) followed by 4 weeks of non-use.

How much Growth Hormone Releasing Peptides (GHRP) should be used?
The saturation dose in most studies on Growth Hormone Releasing Peptides (GHRP) is defined as either 100mcg or 1mcg/kg. However that would assume a 100% pure peptide. Note: In general you it is recommended that your dose is rounded up to 150mcg unless the manufacturer advises otherwise.

This means that 100mcg will saturate the receptors fully, but if you add another 100mcg to that dose only 50% of that portion will be effective. If you add an additional 100mcg to that dose only about 25% will be effective. Perhaps a final 100mcg might add a little something to growth hormone release but that is it.

If 100mcg is the saturation dose, you could add more (up to 300-400mcg) and get a little more effect. A 500mcg dose will not be more effective than a 400mcg, perhaps not even more effective than 300mcg.

The additional problems with higher dosages are desensitization and cortisol/prolactin side-effects.

Ipamorelin and GHRP-6 at the saturation dose of 100mcg does not really increase prolactin & cortisol but may do so slightly at higher doses. This rise is still within the normal range. It can be used at saturation dose (100mcg) three or four times a day without risk of desensitization.

GHRP-2 is more effective then GHRP-6 at causing growth hormone release but at the saturation dose of a 100mcg or higher may produce a slight to moderate increase in prolactin & cortisol. This rise is still within the normal range although doses of 200 - 400mcg might make it the high end of the normal range. It can be used at saturation dose several times a day will not result in desensitization.

Hexarelin in general is the most effective at causing an increase in growth hormone release. However it has the highest potential to also increase cortisol & prolactin. This rise will occur even at the 100mcg saturation dose. This rise will reach the higher levels of what is defined as normal. It has been shown to bring about desensitization but in a long-term study the pituitary recovered its sensitivity so that there was not long-term loss of sensitivity at saturation dose. Even at 100mcg three times a day will likely lead to some down regulation within 14 days.

If desensitization were to ever occur for any of these Growth Hormone Releasing Peptides (GHRP) simply stop administering them for several days and this will remedy the effect.

How long should Growth Hormone Releasing Peptides (GHRP) be used?
In most studies no adverse side effects were reported with continuous use per the dosage limits in the above answer.

Does Growth Hormone Releasing Hormone (GHRH) and Growth Hormone Releasing Peptides (GHRP) work together better?
It is well documented and established that the concurrent administration of Growth Hormone Releasing Hormone (GHRH) and Growth Hormone Releasing Peptides (GHRP) results in synergistic release of growth hormone from pituitary.

In other words if Growth Hormone Releasing Hormone (GHRH) contributes a growth hormone amount quantified as the number 2 and Growth Hormone Releasing Peptides (GHRP) contributed a growth hormone amount quantified as the number 4 the total growth hormone release is not additive (i.e. 2 + 4 = 6). Rather the whole is greater than the sum of the parts such that 2 + 4 = 12.

Can Growth Hormone Releasing Hormone (GHRH CJC-1295) be used alone?
The problem with using only Growth Hormone Releasing Hormone (GHRH) (even the stronger analogs) is that they are only effective when somatostatin is low (the growth hormone inhibiting hormone). So if you administer it in a trough (or when a growth hormone pulse is not naturally occurring) you will add very little growth hormone release. If however you administer it during a rising wave or growth hormone pulse (somatostatin will not be active at this point) you will add to growth hormone release.


Can Growth Hormone Releasing Peptides (GHRP) be used alone?
Yes. They are capable of creating a larger pulse of growth hormone on their own than Growth Hormone Releasing Hormone (GHRH) and they do this with much more consistency and predictability without regard to whether a natural wave or trough of growth hormone is currently taking place.

What is a typical protocol for Growth Hormone Releasing Hormone (GHRH) and Growth Hormone Releasing Peptides (GHRP)?

Studies have suggested the following:
A typical conservation protocol would be:
100-200mcg of Growth Hormone Releasing Peptides (GHRP)
Approximately 5-7 days a week - subcutaneous injections

This can be used once, twice, three or four times a day to make it more effective.
When dosing multiple times a day at least 3 hours should separate the administrations.

A more aggressive protocol would be:
100-200mcg of Growth Hormone Releasing Peptides (GHRP) plus
100-300mcg of Growth Hormone Releasing Hormone (GHRH).
Approximately 5-7 days a week - subcutaneous injections

This can be used once, twice, three or four times a day to make it more effective.
When dosing multiple times a day at least 3 hours should separate the administrations.

Studies suggest that a once a day dosing pre-bed will give a restorative amount of growth hormone while multiple dosing and/or higher levels will give higher growth hormone & IGF-1 levels which will lead to muscle gain, fatloss and/or injury repair.

Should food be consumed before or after the injection of Growth Hormone Releasing Hormone (GHRH) and/or Growth Hormone Releasing Peptides (GHRP)?
Studies have shown that administration should ideally be done on either an empty stomach or with only protein in the stomach. Fats and carbohydrates blunt growth hormone release. After administering the peptides wait about 20 minutes (no more than 30 but no less than 15 minutes) to eat. At that point the growth hormone pulse has reached its peak and you can eat what you want.

Synthetic Growth Hormone

What is Human Growth Hormone (HGH) Fragment 176-191?
The HGH Fragment is a modified form of amino acids 176-191 at the C-terminal region of the human growth hormone (HGH). Studies have shown that it works by mimicking the way natural HGH regulates fat metabolism but without the adverse effects on insulin sensitivity (blood sugar) or cell proliferation (muscle growth) that is seen with unmodified HGH. Like unmodified GH, the HGH fragment 176-191 stimulates lipolysis (breaking down of fat) and inhibits lipogenesis (the formation of fatty acids and other lipids in the body).

HGH fragment 176-191 is meant to be 12.5 times stronger than human growth hormone (HGH) for weight loss than standard human growth hormone (HGH).

Of particular note is that in studies HGH fragment 176-191 had the ability to increase IGF-1 levels which translates into the fragments ability to give anti-aging effects.

How much Human Growth Hormone (HGH) Fragment 176-191 should be used?
In most studies favorable results have been shown with dosages between 500-1000mcg or 5-10mcg/kg split into multiple dosages per day.

How long should Human Growth Hormone (HGH) Fragment 176-191 be used?
In most studies no adverse side effects were reported with continuous use per the dosage limits in the above answer.

What is a typical protocol for Human Growth Hormone (HGH) Fragment 176-191?
Studies have suggested the following:
A typical conservation protocol would be:
250mcg in the morning plus
250mcg pre lunch plus
250mcg in the evening (pre-bed).
Approximately 5-7 days a week - subcutaneous injections

A more aggressive protocol would be:
350mcg in the morning plus
350mcg 30 minutes prior to training
350mcg in the evening (pre-bed).
Approximately 5-7 days a week - subcutaneous injections

When dosing multiple times a day at least 3 hours should separate the administrations.

Should food be consumed before or after the injection of Human Growth Hormone (HGH) Fragment 176-191?
Studies have shown that administration should ideally be done on either an empty stomach or with only protein in the stomach. Fats and carbohydrates blunt growth hormone release. After administering the peptides wait about 20 minutes (no more than 30 but no less than 15 minutes) to eat. At that point the growth hormone pulse has reached its peak and you can eat what you want

More Peptide Info...




PEGylated Mechano Growth Factor


PEGylated Mechano Growth Factor (PEG-MGF)
PEGylated Mechano Growth Factor (MGF)
Russianstar " Experiences with MGF and PEG MGF a complete guide.
This article will discuss the use of Mechano growth factor and clear up a few myths.

WHAT IS MGF?

Mechano Growth Factor (MGF) also known as IGF-1Ec is a growth factor/repair factor that is derived from exercised or damaged muscle tissue, Its called MGF as IGF-1Ec is a bit of a mouthful and harder to identify amongst the other igf variants.
What makes MGF special is its unique role in muscle growth.
MGF has the ability to cause wasted tissue to grow and improve itself by activating muscle stem cells and increasing the up regulation of protein synthesis, this unique ability can rapidly improve recovery and speed up muscle growth.
MGF can initiate muscle satellite (stem) cell activation in addition to its IGF-Ireceptor domain which then in turn increases protein synthesis turnover, and therefore can if used correctly improve muscle mass over time.
The liver produces 2 kinds of MGF splice variants of igf..
1) IGF-1Ec This is the first phase release igf splice variant and it appears to stimulate satellite cells into activation, This is the closest variant to synthetic MGF.

2) liver type IGF-IEa this is the secondary release of igf from the liver, and its far less anabolic.

MGF differs from the second variant IGF-IEa as it has a different peptide sequence which is responsible for replenishing the satellite cells in skeletal muscle, in other words it is more anabolic and longer acting than the systematic release of the second MGF liver variant.

So just think of MGF as a highly anabolic variant of igf. After you have trained, the IGF-I gene is spliced towards MGF then that causes hypertrophy and repair of local muscle damage by activating the muscle stem cells as well as other important anabolic processes, including the above mentioned protein synthesis, and increased nitrogen retention.

In rats some studies have shown muscle mass increases of 20 percent from a single mgf injection.. somehow I think many of these studies are not accurate, however the potential is undeniable.

HOW TO USE MGF

Now when you train what happens to your muscles, they break down, the cells are damaged, muscle tissue needs to be repaired and your body produces 2 forms of MGF splice variant, The first initial release of the above mentioned number 1 variant from the liver helps muscle cell recovery, if there is no MGF then muscle cells die, that's the large and small of it.
As muscle is a post-mitotic tissue and as such cell replacement is not a means of tissue repair , If the cells are not repaired they die and your muscles get smaller and weaker.
The muscle The pool of these stem cells is apparently replenished by the action of MGF, which is produced as a pulse following damage.

Now with synthetic injections of MGF you can increase the pulse and so speed up recovery, and increase the muscle tissue cells by stimulating satellite cells into full maturity. 200mcg bi laterally is the very best choice of dosing in muscles trained.
The only problem with MGF and this is the reason I don't like it, is that it has such a short half life, just a few minutes, between 5-7, and it needs to be used immediately post workout as it wont work if muscle tissue hasn't been damaged, that's why for me personally i think the best option is PEG MGF.
Nevertheless MGF has a huge role to play, and is administered to those with muscle wasting diseases and for those who are elderly and have lost muscle mass for good reason, it is EXTREMELY anabolic.


HOW TO USE PEG MGF



This is a very important section.
When using MGF that's pegylated that's the addition of Polyethylene glycol, its a non toxic additive that increased the half life of MGF from minutes to hours.
This means its uses and versatility make it a tremendous addition to a bodybuilders arsenal.
I have found it most effective as its effects are systematic, that means they have a whole body effect wherever muscle has been damaged or is diseased.

The next aspect we need to look at is how to make the most use of a long acting version of MGF.
When your muscle is damaged your body releases a pulse of an MGF splice variant as i outlined above, followed by a less anabolic longer acting version from the liver... So it seems a waste to inject MGF at this time as you will just blunt your body's own release, your not enhancing it.
So using PEG MGF on non workout days is actually the very best route, the muscle has been damaged, so there are plenty of receptors for MGF, the effects are systematic so all muscles will be helped to recover through increased nitrogen retention, protein turnover, and satellite cell activation. Recovery is just going to sky rocket.
Doing this means your increasing the length of your body's own mechanism for muscle repair and growth, your opening up the anabolic window.

NOW PLEASE TAKE CAREFUL NOTE.

Running PEG MGF in synergy with IGF is perfect but there are things you need to know.
If you dose them at the same time, as IGF has such strong receptor affinity, The effectiveness of MGF will just be wasted.
The best option and the very best choice I feel is this....
IGF DES on workout days Pre workout, or IGF1-LR3 this wont blunt your body's own MGF release from the liver, and whereas IGF1-LR3 has a more systematic effect and only a very small localized anabolic effect, DES on the other hand is very anabolic in a localized way, so bring up lagging muscle parts with DES, and then the following day Dose MGF at 200-400mcg subq to increase recovery and the mechanism for growth. Perfect synergy.

Over a 4 week run i noticed about 4lb increase with the PEG MGF and DES partnership. And roughly the same weight in fat loss, very impressive, some though have noted far greater increases in muscle mass.
If your on an AAS cycle there is no need for the addition of DES as IGF levels will already be elevated, then the addition of PEG MGF can take your recovery and gains to a new level.

STORAGE ETC

Dosing 3 times a week is best, and 1ml of BA water for every 2mg is optimal. Storage in the fridge for up to 6 months. Avoid exposure to heat or sunlight.


According to RS nice protocol of IGF DES and PEG MGF will be
IGF DES during workout 80mcg and above ( about 4X week)
PEG MGF next day of workout of day 200-400 mcg at 2 pm (about 3X week)

but for beginners
50mcg IGF DES and 200mcg PEG MGF is sufficient
My bro got nice results with these peptides
Gained about 8 pounds pure muscle mass in just 5 weeks
__________________
Current cycle
week 1-16 test e 500mg/week
week 1-14 deca 400mg/week
 


Quick summary: MGF is a splice variant of the IGF produced by a frame shift if the IGF gene. MGF increase the muscle stem cell count, so that more may fuse and become part of adult muscle cells. This is a process required for adult muscle cells to continue growing.

Why PEGylate MGF?
MGF exhibits local effects in skeletal muscle and without modification is not systemic (can’t travel through the body). The problem with synthetic MGF is that it is introduced IM and is water based so it goes into the blood stream. MGF is not stable in the blood stream for more than a matter of minutes. Biologically produced MGF is made locally and does not enter the bloodstream and is short acting so stability is not an issue. By PEGylating the MGF we can make synthetic MGF injected IM almost as efficient as local produced MGF. Clinically proven Advanced Pegylation, the technology of polyethylene glycol (PEG) conjugation, holds significant promise in maintaining effective plasma concentrations of systemically administered drugs. It does this by surrounding part of the peptide with a unique structure made of polyethylene glycol, which can be attached to a protein molecule. The result of a correct PEGylation is similar to the protective mechanism of a turtle shell. The polyethylene glycol groups protect the peptide but don’t surround it completely. The active sites of the peptide are still free to do their biological function. In this case the shell is a negative charged shield against positively charged compounds that would affect the protein. This also provides a nice steric chamber for the peptide to reside in. So it’s a happy turtle

Neurological research has shown that utilizing PEGylated MGF resulted in a longer more stable acting version of the MGF peptide in serum/blood.

Bottom line
PEGylation can improve performance and dosing convenience of peptides, proteins, antibodies, oligonucleotides and many small molecules by optimizing pharmacokinetics, increasing bioavailability, and decreasing immunogenicity and dosing frequency. PEGylation also can increase therapeutic efficacy by enabling increased drug concentration, improved biodistribution, and longer dwell time at the site of action. As a result, therapeutic drug concentrations can be achieved with less frequent dosing—a significant benefit to patients who are taking injected drugs.

The PEG itself does not react in the body and is very safe. PEG has been approved by the US Food and Drug Administration (FDA) as a base or vehicle for use in foods and cosmetics and in injectable, topical, rectal and nasal pharmaceutical formulations. PEG has demonstrated little toxicity, is eliminated intact by the kidneys or in the feces and lacks immunogenicity. The risk associated with current PEGylated drugs are due to the way the drug itself acts not the PEG. MGF, as it is being currently sold, is getting a bad rep from people due to the fact they feel that they are not seeing gains from it. Many people believe that the use of MGF in their cycles or protocols just flat out won't work, however, this is far from the truth.
More MGF information
Complete Overview of MGF or IGF-IEc

From its sequence, MGF is derived from the IGF-I gene by alternative splicing and has different 3' exons to the liver or systemic type (IGF-IEa). It has a 49 base pair insert in the human, and a 52 base pair insert in rodents, within the E domain of exon 5. This insert results in a reading frame shift, with a different carboxy (C) terminal sequence to that of systemic IGF-IEa. MGF and the other IGF isoforms have the same 5' exons that encode the IGF-I ligand-binding domain. Processing of pro-peptide yields a mature peptide that is involved in upregulating protein synthesis. However, there is evidence that the carboxy-terminal of the MGF peptide also acts as a separate growth factor. This stimulates division of mononucleated myoblasts or satellite (stem) cells, thereby increasing the number available for local repair

During the early stage of skeletal muscle development, myoblasts (muscle stem cells) fuse to form syncytial myotubes, which become innervated and develop into muscle fibers. Thereafter, mitotic proliferation of nuclei within the muscle fibers ceases. However, during postnatal (after development) growth, additional nuclei are provided by satellite cells (myoblast) fusing with myotubules. Muscle damage-recovery seems to have a similar cellular mechanism, in that satellite cells become activated and fuse with the damaged muscle fibers (reviewed by Goldring et al. 2002). This is also pertinent to certain diseases such as muscular dystrophy in which muscle tissue is not maintained and which have been associated with a deficiency in active satellite (stem) cells (Megeney et al. 1996; Seale & Rudnicki, 2000) and in myogenic factors (Heslop et al. 2000). Skeletal muscle mass and regenerative capacity have also been shown to decline with age (Sadeh, 1988; Carlson et al. 2001). The reduced capacity to regenerate in older muscle seems to be due to the decreased ability to activate satellite cell proliferation (Chakravarthy et al. 2000). The markedly lower expression of MGF in older rat muscles (Owino et al. 2001) and human muscle (Hameed et al. 2003) in response to mechanical overload has been associated with the failure to activate satellite cells, leading to age-related muscle loss (Owino et al. 2001). Your muscle cells can not grow once they have reached a certain size unless they obtain more nuclei from the myoblast. MGF increases the myblast available to donate their nuclei to the adult muscle cell.
“MGF appears to have a dual action in that, like the other IGF-I isoforms, it upregulates protein synthesis as well as activating satellite cells. However, the latter role of MGF is probably more important as most of the mature IGF-I will be derived from IGF-IEa during the second phase of repair. Nevertheless, it has been shown that MGF is a potent inducer of muscle hypertrophy in experiments in which the cDNA of MGF was inserted into a plasmid vector and introduced by intramuscular injection. This resulted in a 20 % increase in the weight of the injected muscle within 2 weeks, and the analyses showed that this was due to an increase in the size of the muscle fibers (Goldspink, 2001). Similar experiments by other groups have also been carried out using a viral construct containing the liver type of IGF-I, which resulted in a 25 % increase in muscle mass, but this took over 4 months to develop (Musaro et al. 2001). Hence, the dual role MGF plays in inducing satellite cell activation as well as protein synthesis suggests it is much more potent than the liver type or IGF-IEa for inducing rapid hypertrophy.”

These results are based on actual transplantation of the DNA coding for the peptides. This is a permanent effect and much more potent than IM injections of the peptide itself. You will not see a 20% increase in muscle mass through IM injections as claimed above.


PEGylated MGF dosing Protocols
The PEGylated version is going to be much longer lasting making a 1-2 dose per week procedure possible. I still think its best used with IGF or AAS to maximize the benefits so here are some sample protocols

Once a week PEG MGF/ IGF
Sunday 100-300 mcg MGF you can choose to site inject if you wish. I think splitting large doses may benefit.
Monday –Fri IGF 50mcg e/d

Twice a week PEG MGF / IGF
Sunday and Wed MGF 50-150 mcg
MT, Th, F IGF 50 mcg

These protocols are just to start as this is brand new feel free to tweak them if you like. I will update them after we have done some testing.

 

MGF is a splice variant of the IGF gene which increases stem cell count in the muscle and allows for muscle fibers to fuse and mature. This is a process required for growth of adult muscle. Natural MGF is made locally and does not travel into the bloodstream. Synthetic MGF is water based and when administered intramuscularly, travels into the bloodstream. MGF is only stable in the blood stream for only a few minutes.
PEGylation is the act of attaching a Polyethylene glycol (PEG) structure to another larger molecule (in this case, MGF). The PEG acts as a protective coating and the theory here is that this will allow the MGF to be carried through the blood stream without being broken down.
 
Background
I have to be honest here, and say that in my estimation, PEGylating MGF is basically something a research chemical company did to have a bit of a market with no competition for awhile. That’s not to say that it’s not a decent product, but honestly, in this particular case, I feel that marketing was in the drivers seat with the development of this version of MGF, and science was in the backseat asking “are we there yet?”.
 
Action
MGF is produced biologically when muscle fibers are broken down through resistance (weight training). It is a potent factor in muscle growth. MGF stimulates muscle growth, creates new muscle fibers, promotes nitrogen retention and increases protein synthesis. This compound is commonly used for overall growth of muscle and to promote growth in body parts that are not up to par with the rest of the user's physique. Results usually depend on dosage. Fat loss and strength increases are not typically seen with MGF's use (as they are in IGF-1 use).
The PEG itself is safe for use as it is approved by the US Food and Drug Administration (FDA) and does not react in the body. The PEG is not broken down in the body and excreted (intact) through urine or feces. Any risk associated PEGylated drugs is due to drug itself not the PEG per se.
 
Technical Data
In a study on older rodents, muscle fiber reduction in their older muscles was found to be attributed to decreased activity of satellite cells (1). After a certain size was reached, growth ceased. In the presence of MGF, satellite cells became activated and hypertrophy in mature muscles continued.
In experiments where MGF was administered intramuscularly, there was a 20% increase in the weight of the injected muscle fibers within 2 weeks (2). In further studies, it took 4 months for IGF to cause a 25% increase in muscle mass (3). MGF was found to be more potent than IGF-1Ea in rapid muscle growth (4).
[Note: This data is on “regular” MGF, not the Pegylated version….we can assume similar results, however]
 
User Notes
Although the science looks impressive on paper, in the real world, we see something totally different. While PEGMGF should have theoretically given the athletes who use it better results than regular MGF, it struggles to provide even the same results at a higher dosage (judging from the athletes I have personally spoken to).
So does that mean it’s useless?
No, not at all. Not entirely…
 
I think that the PEGylation is actually a potentially useful addition to MGF if properly used. If we assume that the PEGylation will extend the life of the MGF in the body somewhat, then we can use it in a very specific manner to help our gains. It is nowhere near as good as regular MGF though, and I wouldn’t use it unless I really had the disposable cash on hand.
 
I feel that, based on conversations with several athletes and bodybuilders, that PEGMGF is best used in conjunction with (not instead of) regular MGF (and IGF). I feel that if one were to use my Peptides protocol (to read about that in detail, check out the article “Peptides: The Next Frontier in Hypertrophy”), I think that PEGMGF is probably best used on off-days from training, to keep MGF levels elevated and get additional hypertrophy from the longer releasing PEGMGF.
 
So, along with regular MGF and Lr3IGF-1, if I felt it to be necessary, I might throw in some PEGMGF on off-days from training, to get additional growth (and again, if it were me, I’d probably recommend 400-500mcg of PEGMGF on off days, with a regular dose of 200mcg of regular MGF + 100mgs of Lr3IGF-1 on training days, as per my article).
 
For most athletes I’ve spoken to and worked with, this is what we’ve found to be optimal. Again, though…I’m not very fond of this product, and it’s best used (if at all), as a possible adjunct to an IGF + MGF cycle, and never in place of regular MGF. Unfortunately, it just didn’t pan out as people hoped it would, but it’s not a complete waste of money.

More Peptide Info...




Hexarelin


Hexarelin is a synthetic hexaptide which has GH-releasing properties. Hexarelin, administered subcutaneously produces a dose-dependent GH response from the Pituitary.

The advantages of having HGH secreted in larger amounts in the body would be similar to what happens when injectable growth hormone is administered. Effects from GH include increased bone mineral density, increased mitosis and meiosis which leads to more muscle mass, triglyceride hydrolysis which causes prominent fat loss, connective tissue strengthening, and improved skin elasticity.

GH secretion also leads to the liver secreting more IGF-1 (Insulin-Like Growth Factor One), which by itself has a host of effects similar to GH. Users of IGF-1 typically experience increased strength and muscle mass, as well as a very pronounced fat loss.

Therefore, by injecting Hexarelin, the user will experience all of the effects of both Growth Hormone as well as IGF-1. However, since Hexarelin actually stimulates the body to produce more GH, it may be likely that the eventual shutdown of the body’s natural GH production may be avoided, as is seen with injectable GH. For this reason, many athletes use Hexarelin alone, but others have used it after a Growth Hormone or Insulin-Like Growth Factor one cycle, to “jumpstart” their own natural GH and IGF-1 production.

More Peptide Info...




Tissue Growth & Protection and Practical use of peptides


Tissue Growth & Protection and Practical use of peptides



Peptides, Tissue Growth & Protection and Practical use surrounding them Hello all of you in internet land!
Today I wish to cover the subject of peptides and their possible uses.
There seems to be a lot of people out there unsure of what peptides are or flat out think they are some sort of gimmick.
I was at one point in time in the same boat, so no worries keep reading and you might learn something. After many years of research on this topic and countless personal experiences with peptides I feel I am qualified to try to help others out there by putting together this article covering the most popular peptides, their uses, how to use them safely and most effectively.

What so WHAT in the world is a PEPTIDE???

Isn’t that the stuff in my wife’s shampoo???

Well…… I might be. But not all peptides are the same! Just like not all amino acids are the same.
Peptides are actually very similar to amino acids (protein molecules) believe it or not.
A peptide is a short, large molecule of an amino acid molecule that can bind chemically to other molecules to form a larger molecule by peptide bonds. They are listed as a peptide or protein depending on their size.

I know it sounds confusing and in some ways it is. But it is not too hard to understand them.
There are many kinds of peptides out there some are your basic protein type peptide that I will not bother to cover at this time or that would make this more of a diet article than a peptide article. Another is a “peptide hormone” they are secreted into the blood stream and have an endocrine function in the body.[1]

There is even something called a neuropeptide. One of many for e.g. is DSIP (Delta Sleep-inducing Peptide). They are small protein-like molecules used by the neurons to communicate.
They are much smaller than a neurotransmitter and are considered neuronal signaling molecules and they affect many functions in the brain like; pain, hunger, memory and can even effect you’re learning abilities!
Still think Peptides might be a gimmick? HA I sure don’t. I think they are GREAT!
No I won’t be talking about neuropeptides today, but I wanted to at least mention them because I feel they are pretty cool and very important.


Today I will be talking about Peptide Hormones!

Peptide hormones are not the same as steroid hormones.
Steroid hormones are synthesized from cholesterol, and are lipids (they are fat based). While peptide hormones are proteins and are formed by a sequence of amino acids.
As mentioned above these are the ones that have physical effects on the body like growth and repair and has been of very big interest to the bodybuilding scene and in recent years I feel at a massive scale due to the internet and many places selling these peptides.
I felt I really should put something together about these powerful peptides and how they might help you in your quest to recovery, fat loss and growth.



I will start with the basics of what each one does then I will get into more detail on how you can use them safely and effectively.

GHRP-2
Is a human growth hormone secretagogue. That means it stimulates the body's own release of HGH. It is a ghrelin receptor agonist is also seems to have some protective effect on some tissues and an anti-inflammatory effect as well. The excessive hunger some feel with GHRP-6 use does not seem to be an issue with GHRP-2. The half-life is about 20 minutes so multiple doses per day are optimal.

GHRP-6
Is also a human growth hormone secretagogue and stimulates the body's own release of HGH. It is a ghrelin receptor agonist and also seems to have some protective effect on some tissues and an anti-inflammatory effect as well. The half-life is about 20 minutes so multiple doses per day are optimal.
*Note: GHRP-6 seems to cause excessive hunger in some people compared to GHRP-2. It is not a bad thing per say but depending on if your bulking or cutting you may prefer one over the other.

CJC-1295
Is a growth hormone releasing hormone (GHRH) and it aides in the stimulation of the pituitary gland to increase production of growth hormone and stimulates GH and IGF-1 secretion. It will keep a steady increase of HGH without an increase in prolactin as can be an issue for some peptides of this nature. It is an analog to a peptide that is naturally produced to stimulate pituitary production of growth hormone. It has a half-life of about 7-10 days. This means once a week dosing is optimal in most cases.

CJC-1293 (CJC w/o Dac)
Is also a growth hormone releasing hormone (GHRH) and it aides in the stimulation of the pituitary gland to increase production of growth hormone and stimulates GH secretion. It is an analog to a peptide that is naturally produced to stimulate pituitary production of growth hormone. The GH pulse from a single administration of CJC-1293 seems to be greater than that of CJC-1295 but duration is shorter. There is debate on which is better but both are useful regardless.

IGF1 Des
IGF-1 Des is an IGF-1 analogue of our native igf1 with the last 3 amino acids in the IGF-1 chain removed. That leads it to have little protein binding (good thing), but similar action causing it to be about 10 times more potent than normal IGF-1.[2] The active life is still fairly short, only about 20 minutes making multiple doses daily optimal for some users while others still feel once a day dosing is still worthwhile and the way to go.

IGF1LR3
Is also an IGF1 analogue with a 13 amino acid extension at the N-terminus. The alteration leads to less binding in the body greatly extends its half-life from 20min to about 20+ hours. Once a day dosing is optimal.

IGF1Ec / Mechano Growth Factor (MGF)
IGF1 Ec is derived from IGF-I but its effects differ from the systemic IGF-I produced by the liver. It is released as a pulse following muscle damage, is involved in the activation of muscle stem cells and also seems to protect the myocardium against ischaemia, which improved cardiac function after heart attacks. There is debate on dosing but i feel post workout (once daily even on non workout days) is a good way to go about it.[3]

MT2
Melanotan II (MT2) is a melanocortin. Melanocortins (MCs) are a family of multifunctional peptidergic hormones. MT2 is an analog of these and plays a role in the tanning process but will vary between skin types with its use. It is not really used in any growth as HGH or igf1 would be, but I feel due to its potential skin protection that I should add it in this article even if tanning is not the main focus of this article.



As you can see all this stuff seems to revolve around IGF1 and HGH, so to understands its effects does not mean needing to fully understand each and every peptide (though a basic knowledge should be known about each one you use). Each peptide is working as either an IGF1 analog or as a HGH releaser and HGH converts to IGH1 giving most of its tissue growing effects anyway.

It’s more understanding what IGF and HGH do in the body, to fully understand what these peptides can potentially do for you.

I would like to talk mainly about IGF1 as I feel it is the main cause for growth over that of HGH solely.[4]
The liver is the organ mostly responsible for the production of serum IGF-I even when taking exogenous HGH it is still mainly converted in the liver.

IGF-1 acts differently in different types of tissues its not all tissues grow from its effects. When active in muscle cells and associated cell’s they stimulate growth by increasing protein synthesis along with amino acid absorption. IGF-1 also plays a role as a source of energy; IGF mobilizes fat for use as energy in adipose tissue by preventing insulin from transporting glucose across cell membranes. This results in the cells having to switch to burning off fat as a source of energy which I feel is a great quality about IGF-1.IGF also seems to mimic's insulin in the human body. It makes muscles more sensitive to insulin's effects.[5][6]

I think one of the most interesting effect’s IGF has on the body is its ability to cause hyperplasia, that is when an actual splitting of cells occurs leading to more cells. You are basically your growing more cells with the use of HGH and IGF-1.
Hypertrophy is what occurs when practising weight training and steroid use. Hypertrophy is simply an increase in the size of muscle cells but not growing new cells. In humans after you are done puberty you mostly have a set number of muscle cells that you have developed with that doesn’t vary much.All you would be able to do is increase the size of these muscle cells, but you don't actually gain more of them.
This is not good for someone with “bad genetics” in the area of muscle cells.
With IGF use you are able to cause hyperplasia which increases the number of muscle cells and gives you the ability to change your genetic capabilities in terms of muscle tissue and cell count.[6]
Being able to alter a person’s capacity to build muscle density and size is an awesome thing to have control over.
When you do a “cycle” of HGH releasing peptides or even straight use of IGF1 analogs on its own, you not only add to growth and recovery while on them, you give yourself a greater number of cells to work with and down the line grow then.

When you finish a cycle of IGF-1…. in a way you are not really finished because you are still left with these new cells regardless of stopping the use of IGF1 or HGH releaser peptides and that is one of the things I just LOVE about HGH and IGF1. The fact you have residual effects is awesome for muscle building!


OK, OK we know igf1 causes growth of size and cells, but how do I use this stuff effectively?
Well by knowing the basics of each peptide, how they might have a synergy when used together and fully understanding the effects of HGH and igf1 that’s how!

Unfortunately a lot of the use of IGF1 and HGH by bodybuilders and athletes is an underground trend of their use and you might not find some of the info needed to stack them optimally together or use them in a home setting.
I wish to give you some of that information here.

Secretagogues are different from GHRH's, they share no sequence relation and derive their function through action at a different receptor and it has been established that the use of Growth Hormone Releasing Hormone (CJC1295 is one for e.g.) and a Growth Hormone Releasing Peptide (GHRP-6 or GHRP-2 for e.g.) together results in synergistic release of GH from pituitary.
It is like saying 2+2=5 not 4, if you get what I am trying to say.

I strongly rec stacking a GHRP with a GHRH for optimal results in tissue growth and fat loss, even if also using an IGF1 analog in the same cycle as some like to do.


Here are some good examples of “peptide cycles” (Taken Sub Q):


1#
Wk1-8 40mcg ed IGF-1LR3

2#
Wk1-12 1000mcg (1mg) every week CJC-1295
Wk1-12 100mcg 2-3X ed GHRP-2 or GHRP-6
Wk1-12 10-20mcg ed IGF1 Ec (post workout’s)

3#
Wk1-12 100mcg 2-3X ed CJC-1293 (CJC w/o Dac)
Wk1-12 100mcg 2-3X ed GHRP-2 or GHRP-6

4#
Wk1-8 40mcg ed IGF-1LR3
Wk1-12 100mcg 2-3X ed CJC-1293 (CJC w/o Dac)
Wk1-12 100mcg 2-3X ed GHRP-2 or GHRP-6

5#
Wk1-8 10-20mcg 1-2X ed IGF-1 Des

6#
Wk1-8 10-20mcg 1-2X ed IGF-1 Des
Wk1-12 100mcg 2-3X ed CJC-1293 (CJC w/o Dac)
Wk1-12 100mcg 2-3X ed GHRP-2 or GHRP-6

7#
Wk1-8 10-20mcg 1-2X ed IGF-1 Des
Wk1-12 1000mcg (1mg) every week CJC-1295 (Sub Q)
Wk1-12 100mcg 2-3X ed GHRP-2 or GHRP-6

8# (MT2 cycle is for tanning purposes only, dependent on skin type and these are guidelines only)
Wk1-4 0.5mg 2-3X a week of MT2 (10min tan every week)
Wk4-8 0.5mg 1X a week of MT2 (10min tan every other week)
Wk8-? 0.5mg 1X a month of MT2 (tan and dose as needed) *maintenance

These cycles above would be optimal ways of using these peptides for muscle growth and fat loss.

Using one or more of the HGH releasing peptides along with an IGF peptide like IGF-1lr3 could lead to growth and more fat loss over just the use of IGF-1lr3.
But the use of one or more of the HGH releasing peptides without IGF-1 could lead to less total gains in mass as well. So stacking is goal dependent.
I feel they stack together very nicely personally and I highly recommend IGF1LR3 to my friends new to and interested in peptides.

IGF1lr3 or IGF1 Des are good peptides to start out with due to the simple ease of their.
Then once you feel comfortable I would highly recommend stacking it with one of the GHRP’s and GHRH’s for maximum results.

There are new discoveries every day in the field of “the human body” and I would be VERY Happy If I had some effect on this knowledge spreading, so I hope you learned something and enjoyed my article on these peptides and how to use them most effectively and safely.

I look forward to helping all I can and making more of these kinds of informative articles.
Till the next time,


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