PEG-MGF FAQs
Does PEG-MGF have to be injected into the muscle?Due to its long half-life, PEG-MGF (Pegylated Mechano Growth Factor, also known as IGF-1ec) does not need to be injected into muscle tissue but given that MGF is normally released in the body as a result of muscle trauma, it is recommended, but not essential, that you inject PEG-MGF after weight training into the muscle group just worked. Since injections are done with an insulin syringe this limits most people to bicep, calf muscle and possibly shoulder injections. Other muscles generally have a layer of subcutaneous fat covering them which will prevent an insulin syringe from reaching the muscle. The only alternative would be to use a syringe barrel + longer syringe (such as 25g) to inject, however dosing would be difficult with this method.
Thankfully, since the addition of PEG (pegylation) to MGF takes its half-life from a few minutes to a few days, an injection into a muscle group which was not just trained, or a sub-q injection, means the peptide will still eventually reach the desired receptors and carry out its positive effects on muscle recovery and growth.
When should I inject IGF-1 LR3 and PEG-MGF and how much?
Due to its long half-life and mechanism of action the injection timing of IGF-1 LR3 is not so critical, however most people inject it pre or post weight training when the muscle receptors are more sensitive. The usual IGF-1 LR3 dosage is 50mcg per day taken on weight training days only. Since PEG-MGF is a growth factor which is naturally only released in response to muscle trauma (such as weight lifting), you should always aim to inject as soon as possible after your workout at a dosage of at least 200mcg per injection.
How long should I inject IGF-1 LR3 and PEG-MGF for?
Both IGF-1 LR3 and PEG-MGF should be used for 4 weeks at a time with the same amount of time off, i.e. one month on, one month off. The reason for this is because the products become less effective at this point due to down-regulation of the receptors (i.e. your muscles are no longer sensitive to the peptides). You therefore may like to take IGF-1 LR3 for one month, then MGF for a month and keep rotating them so you will be using either one of them continuously for maximum results.
Can IGF-1 LR3 and PEG-MGF be taken together?
It is not recommended to inject IGF-1 LR3 and MGF together since they compete for the same receptor sites and IGF-1 LR3 would be a much more powerful binder and probably render the PEG-MGF useless. A better solution would be to rotate them and take IGF-1 LR3 for 4 weeks then PEG-MGF for 4 weeks and keep repeating. If you did want to take both products together the best routine would be to inject IGF-1 LR3 first thing in the morning before breakfast, lift weights in the afternoon and take your PEG-MGF post workout directly into a muscle. It's best to avoid IGF-1 LR3 injections in the evening since it can hinder the body's natural release of growth hormone due to negative feedback on the hypothalamus.
My IGF-1 levels are normal on blood tests; shouldn't they be higher when using IGF-1 LR3?
IGF-1 blood tests look only for bound IGF-1 while the purpose of IGF-1 LR3 is to keep it unbound and therefore bioavailable meaning it will not show up on conventional blood tests. It is the same scenario as for blood tests which examine testosterone levels. Many people can have results showing low or normal testosterone levels, but have high "free testosterone" levels - which is much more important, since only testosterone which is not bound to SHBG (sex hormone binding globulin) can be used by the body.
Therefore your levels of IGF-1 on a blood test are not of much importance and do not take into account the increase from IGF-1 LR3 usage, as they only look at bound IGF-1 (which cannot be used by the body since it's attached to binding proteins).
What are the side effects of IGF-1 LR3 and PEG-MGF?
With PEG-MGF no side effects have been noted by users of the peptide. With IGF-1 LR3 however minor side effects have been mentioned such as hypoglycaemia (low blood sugar), which occurs due to the product being "insulin-like". This can be overcome by consuming carbohydrates post injection to stabilize blood sugar. Some users also notice very strong "pump" effects in the muscle which can make it difficult to do high repetition sets of weights.
How long is IGF-1 LR3 stable after mixing?
If your IGF-1 LR3 peptide vial is freeze-dried, then it will usually be stable for at least 2 months (8 weeks) in the refrigerator after being reconstituted (mixed) with a sterile solution. Since the recommended daily dosage is 50mcg, even if the product is only injected 3-4 times per week this should be plenty of time to use the vial before it could possibly degrade.
What solutions can IGF-1 LR3 be mixed with?
Legitimate manufacturers of IGF-1 LR3 peptides have advised that there is no advantage to specific types of mixing solution over others. The peptide is equally soluble and stable in acetic acide 0.6% solution and bacteriostatic water.
Should IGF-1 LR3 be injected into the muscle or fat?
Due to its long half-life, even if you injected your IGF-1 LR3 peptide into fat, it would still find its way to the binding sites in the muscles of your body. If you have no issue with either type of injection, an intramuscular injection is recommended to allow the start exhibiting its localized effects immediately.
